Stefan Niewiesk

DVM, PhD Diplomate ECLAM


Contact (614) 688-3605 Veterinary Medicine Academic Building
1900 Coffey Road
Columbus, OH 43210
Map Link


Veterinary Biosciences

Center For Retrovirus Research

Professional Training and experience

  • DVM, Veterinary School , Hannover , Germany
  • PhD The University of Würzburg, Germany
  • Diplomate, European College of Laboratory Animal Medicine
  • Habilitation, The University of Würzburg, Germany
  • Fachtierarzt für Versuchstierkunde, Germany
  • Fachtierarzt für Mikrobiologie, Germany

Research Interests

  • Pathogenesis of infection of the respiratory tract with human respiratory viruses
  • Vaccines and antivirals against human respiratory viruses
  • Animal model development (cotton rats and humanized mice as animal models for infectious diseases and cancer) 
  • Academic Leadership and Research Infrastructure


University Memberships

  • Center for Retrovirus Research 
  • Infectious Disease Institute
  • Comprehensive Cancer Center at The Ohio State University 
  • Molecular, Cellular, and Developmental Biology Graduate Program 


  • Veterinary Medical Professional Curriculum and Graduate Education
    • Virology
  • Leadership training and coaching


Complete listing of publications


Publications from students of the Niewiesk laboratory

(Graduate students (PhD, Masters and Diploma) and summer research students)

  • Olivia Harder and Stefan Niewiesk (2022) Respiratory Syncytial Virus Infection Modeled in Aging Cotton Rats (Sigmodon hispidus) and Mice (Mus musculus).

    Advances in Virology, 2022 Mar 9;2022:8637545. doi: 10.1155/2022/8637545. eCollection 2022

  • Olivia Harder; Margaret Martinez; Stefan Niewiesk  (2021) Nonsteroidal Anti-inflammatory Drugs Restore Immune Function to Respiratory Syncytial Virus in Geriatric Cotton Rats (Sigmodon hispidus)                                 
    Virology, 563, 28-37.
  • Kelsey A. Brakel, Basavaraj Binjawadagi, Kristen French-Kim, Olivia Harder, Yuanmei Ma, Jianrong Li, Stefan Niewiesk (2021) Coexpression of respiratory syncytial virus (RSV) fusion (F) protein and attachment glycoprotein (G) in a vesicular stomatitis virus (VSV) vector system provides synergistic effects against RSV infection in a cotton rat model 
    Vaccine, 39, 6817-6828
  • Gia Green, Sara M. Johnson, Heather Costello, Kelsey Brakel, Olivia Harder, Antonius G. Oomens, Mark E. Peeples, Hong M. Moulton, and Stefan Niewiesk (2021) CX3CR1 is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats. 
    Journal of Virology, 95, 10-21.
  • Martinez ME, Capella Gonzalez C, Huey D, Peeples ME, McCarty D, Niewiesk S. (2021) Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats. 
    PLoS One, 16:e0246770
  • Binjawadagi B, Ma Y, Binjawadagi R, Brakel K, Harder O, Peeples M, Li J, Niewiesk S. J (2021) Mucosal Delivery of Recombinant Vesicular Stomatitis Virus Vectors Expressing Envelope Proteins of Respiratory Syncytial Virus Induces Protective Immunity in Cotton Rats.
    Journal of Virology, 95:e02345-20
  • Martinez ME, Niewiesk S, La Perle KMD (2020) Cotton Rat Placenta Anatomy and Fc Receptor Expression and Their Roles in Maternal Antibody Transfer.
    Comparative Medicine, 70:510-519
  • Martinez ME, Harder OE, Rosas LE, Joseph L, Davis IC, Niewiesk S. (2020) Pulmonary function analysis in cotton rats after respiratory syncytial virus infection
    PLOS One, 15(8):e0237404
  • M. Gia Green, Natasha Petroff, Krista M. D. La Perle and Stefan Niewiesk (2018) The role of eosinophils in RSV infection and allergy in cotton rats.
    Comparative Medicine, 68:31-40.
  • Robyn A. Haines, Rebeccah A. Urbiztondo, Rashade A. H. Haynes II, Elaine Simpson, Stefan Niewiesk and Michael D.  Lairmore (2016) Characterization of New Zealand White Rabbit gut-associated lymphoid tissues and utilization as viral oncology model
    ILAR Journal, 57:34-43. 
  • Fichtner AS, Paletta D, Starick L, Schumann RF, Niewiesk S, Herrmann T. (2015) Function and expression of CD1d and iNKT T cell receptor in the cotton rat (Sigmodon hispidus).
    Immunology, 146:618-629.
  • Cecilia Parrula, Soledad Fernandez, Kristina Landes, Devra Huey, Michael Lairmore, Stefan Niewiesk (2014). Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.
    Virus Research, 189C:206-213. 
  • Thomas Carsillo, Devra Huey, Amy Levinsky, Karola Obojes, Jürgen Schneider-Schaulies and Stefan Niewiesk (2014). Cotton Rat (Sigmodon hispidus) signaling lymphocyte activation molecule (CD150) is an entry receptor for measles virus.
    PlosOne, 9(10):e110120. doi: 10.1371/journal.pone.0110120
  • Krista M. D. La Perle, M. Gia Green and Stefan Niewiesk (2014). Trophoblast Deportation to the Lungs of Cotton Rats (Sigmodon hispidus).
    Comparative Medicine, 64:448-55.
  • Dhohyung Kim and Stefan Niewiesk (2014). Synergistic induction of interferon α through TLR-3 and TLR-9 agonists stimulates immune responses against measles virus in neonatal cotton rats.
    Vaccine, 3, 265-70. 
  • Gia Green, Devra Huey and Stefan Niewiesk. (2013). Cotton rats (Sigmodon hispidus): an animal model for respiratory tract infections with human pathogens.
    Lab Animal, 42, 170-176.
  • Dhohyung Kim and Stefan Niewiesk (2013). Synergistic induction of interferon α through TLR-3 and TLR-9 agonists identifies CD21 as interferon α receptor for the B cell response.
    PLOS Pathogens, 9(3):e1003233. 
  • Dhohyung Kim and Stefan Niewiesk (2011). Sidestepping maternal antibody: a lesson from measles virus vaccination
    Expert Review of Clinical Immunology, Editorial, 557-559.
  • Dhohyung Kim, Devra Huey, Michael Oglesbee and Stefan Niewiesk (2011). Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies: New roles for immunoglobulin isotypes and B cell receptors.
    Blood (Cover), 117, 6143-6151.
  • Cecilia Parrula, Soledad A. Fernandez, Bevin Zimmerman, Michael Lairmore and Stefan Niewiesk (2011). Measles virotherapy in a mouse model of adult T cell leukemia/lymphoma.
    Journal of General Virology, 92, 1458-66.
  • Dhohyung Kim, Luis Martinez-Sobrido, Changsun Choi, Natasha Petroff, Adolfo García-Sastre, Stefan Niewiesk, Thomas Carsillo (2011). Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies.
    Journal of Virology, 85, 200-207.
  • Danielle Perrone, Scott Bender and Stefan Niewiesk (2010) Comparison of immune response of CDV-exposed dogs reveals differences between vaccinated and wildtype virus infected dogs as well as shelter dogs.
    Canadian Journal of Veterinary Research, 74, 214-217.
  • Mary Carsillo, Dhohyung Kim and Stefan Niewiesk (2010). Role of AKT kinase in measles virus replication.
    Journal of Virology, 84, 2180-2183.
  • Nicole Runkler, Erik Dietzel, Mary Carsillo, Stefan Niewiesk, and Andrea Maisner (2009). Sorting signals in the measles virus wild-type glycoproteins differently influence virus spread in polarized epithelia and lymphocytes.
    Journal of General Virology, 90, 2474-2482.
  • Mary Carsillo, Kay Klapproth and Stefan Niewiesk (2009). Cytokine imbalance after measles virus infection but no correlation with immune suppression.
    Journal of Virology, 83, 7244-7251.
  • Cecilia Parrula, Bevin Zimmerman, Prasad Nadella, Sherry Shu, Thomas Rosol, Soledad Fernandez, Michael Lairmore and Stefan Niewiesk (2009). Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T cell leukemia.
    Veterinary Pathology, 46,1003-14.
  • Mary Carsillo, Vijay Kumar Kutala, Karen Puschel, Jorge Blanco, Periannan Kuppusamy and Stefan Niewiesk (2009). Nitric oxide production and nitric oxide synthase type 2 expression by cotton rat (Sigmodon hispidus) macrophages reflect the same pattern as human macrophages.
    Developmental and Comparative Immunology, 33,718-24.
  • Karen Pueschel, Annette Tietz, Mary Carsillo, Michael Steward, Stefan Niewiesk (2007). Measles virus specific CD4 T cell activity does not correlate with protection against lung infection or viral clearance. 
    Journal of Virology, 81, 8571-8578.
  • Sabine Streif, Karin Pueschel, Annette Tietz, Jorge Blanco, Volker ter Meulen and Stefan Niewiesk (2004). Effector CD8+ T cells are suppressed by measles virus infection during delayed type hypersensitivity reaction
    Viral Immunology, 17, 604-608
  • Markus Moll, Joanna Pfeuffer, Hans-Dieter Klenk, Stefan Niewiesk, and Andrea Maisner (2004). Polarized glycoprotein targeting affects spread of measles virus in vitro and in vivo
    Journal of General Virology, 85, 1019-1027
  • Bernd Schlereth, Linda Buonocore, Annette Tietz, Volker ter Meulen, John K.Rose and Stefan Niewiesk (2003). Successful mucosal immunization of cotton rats in the presence of MV specific antibodies depends on degree of attenuation of vaccine vector and virus dose
    Journal of General Virology, 84, 2145-2151
  • Iris Gundel, Gerald Weidinger, Volker ter Meulen, Jürgen Heesemann, Holger Rüssmann, and Stefan Niewiesk (2003). Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus induced encephalitis
    Journal of General Virology, 84, 775-779.
  • Joanna Pfeuffer, Karen Püschel, Volker ter Meulen, Jürgen Schneider-Schaulies and Stefan Niewiesk (2003). Extent of measles virus spread and immune suppression differentiates between wildtype and vaccine strains in the cotton rat model (Sigmodon hispidus)
    Journal of Virology, 77, 150-158.
  • Shinji Ohgimoto, Kaori Ohgimoto, Stefan Niewiesk, Ingo M. Klagge, Joanna Pfeuffer, Ian C. D. Johnston, Jürgen Schneider-Schaulies, Armin Weidmann, Volker ter Meulen and Sibylle Schneider-Schaulies (2001). The hemagglutinin protein is an important determinant for measles virus tropism for dendritic cells in vitro and immunosuppression in vivo
    Journal of General Virology, 82, 1835-1844.
  • Gerald Weidinger, Golo Henning, Volker ter Meulen and Stefan Niewiesk (2001). Inhibition of MHC II dependent antigen presentation by neutralization of interferon gamma leads to breakdown of resistance against measles virus induced encephalitis
    Journal of Virology 75, 3059-3065.
  • Gerald Weidinger, Marion Ohlmann, Bernd Schlereth, Volker ter Meulen, Gerd Sutter and Stefan Niewiesk (2001). Vaccination with recombinant modified vaccinia virus Ankara protects against measles virus infection in the mouse and cotton rat model.
    Vaccine 19, 2764-2768.
  • Claudia Neumeister, Ralph Nanan, Tatjana I. Cornu, Carsten G. K. Lüder, Volker ter Meulen, Hussein Naim and Stefan Niewiesk (2001). Measles virus and canine distemper virus target proteins into an TAP independent MHC class I restricted antigen processing pathway.
    Journal of General Virology 82, 441-447.
  • Simone Spreng, Ivaylo Gentschev, Werner Goebel, Gerald Weidinger, Volker ter Meulen and Stefan Niewiesk (2000). Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis.
    Microbes and Infection 2, 1687-1692.
  • Gerald Weidinger, Stephanie Czub, Claudia Neumeister, Pat Harriot, Volker ter Meulen and Stefan Niewiesk (2000). Role of CD4+ and CD8+ T cells in the prevention of measles virus induced encephalitis in mice
    Journal of General Virology 81, 2707-2713.
  • Bernd Schlereth, John K.Rose, Linda Buonocore, Volker ter Meulen and Stefan Niewiesk (2000). Successful vaccine-induced seroconversion by single dose immunization in the presence of measles virus specific maternal antibodies.
    Journal of Virology 74, 4652-4657.
  • Bernd Schlereth, Paul-Georg Germann, Volker ter Meulen and Stefan Niewiesk (2000). DNA vaccination with both the hemagglutinin and the fusion proteins but not the nucleocapsid protein protects against experimental measles virus infection
    Journal of General Virology 81, 1321-1325.
  • Claudia Neumeister and Stefan Niewiesk (1998) Recognition of measles virus infected cells by CD8+ T cells depends on the H-2 molecule.
    Journal of General Virology 79, 2583-2591
  • Stefan Niewiesk, Ingo Eisenhuth, Anthony Fooks, J.C.S. Clegg, Jens-Jörg Schnorr, Sibylle Schneider-Schaulies, and Volker ter Meulen (1997). Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins.
    Journal of Virology 71, 7214-7219.