Scott P. Kenney


Assistant Professor

Contact (330) 263-3747 Food Animal Health Building
1680 Madison Ave.
Wooster, OH 44691
Map Link


Veterinary Preventive Medicine

Professional Training and experience

  • 2002, BS, The Pennsylvania State University, University Park, PA
  • 2008, PhD, The Pennsylvania State University College of Medicine, Hershey, PA

Research Interests

  • Comparative Virology - Hepatitis E virus and Arterivirus
  • Veterinary Virology - Porcine Reproductive and Respiratory Disease Virus (PRRSV) and Porcine Circovirus
  • Zoonotic Diseases - Hepatitis E virus
  • Emerging Infectious Diseases of Livestock and Poultry
  • Retroviruses
  • Zika Virus



  • Kenney SP, Wang Q, Vlasova A, Jung K, Saif L. Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease. Vet Pathol. 2020 Dec 28:300985820980842. doi: 10.1177/0300985820980842
  • Hu H, Jung K, Kenney SP, Saif LJ. Isolation and Tissue Culture Adaptation of Porcine Deltacoronavirus: A Case Study. Methods Mol Biol. 2020;2203:77-88. doi: 10.1007/978-1-0716-0900-2_6
  • Tian D, Yugo DM, Kenney SP, Lynn Heffron C, Opriessnig T, Karuppannan AK, Bayne J, Halbur PG, Meng XJ. Dissecting the potential role of hepatitis E virus ORF1 nonstructural gene in cross-species infection by using intergenotypic chimeric viruses. J Med Virol. 2020 Jun 26. doi: 10.1002/jmv.26226.
  • ]Helmy YA, Fawzy M, Elaswad A, Sobieh A, Kenney SP, Shehata AA. The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control. J Clin Med. 2020 Apr 24;9(4):1225. doi: 10.3390/jcm9041225.
  • Boley PA, Alhamo MA, Lossie G, Yadav KK, Vasquez-Lee M, Saif LJ, Kenney SP. Porcine Deltacoronavirus Infection and Transmission in Poultry, United States. Emerg Infect Dis. 2020 Feb;26(2):255-265. doi: 10.3201/eid2602.190346.


  • CD8+ lymphocytes but not B lymphocytes are required for protection against chronic hepatitis E virus infection in chickens. Rogers E, Todd SM, Pierson FW, Kenney SP, Heffron CL, Yugo DM, Matzinger SR, Mircoff E, Ngo I, Kirby C, Jones M, Siegel P, Jobst P, Hall K, Etches RJ, Meng XJ, LeRoith T. J Med Virol. 2019 Nov;91(11):1960-1969. doi: 10.1002/jmv.25548. Epub 2019 Jul 25.
  • The Current Host Range of Hepatitis E Viruses. Kenney SP. Viruses. 2019 May 17;11(5). pii: E452. doi: 10.3390/v11050452. Review. PMID: 31108942
  • Emerging and re-emerging coronaviruses in pigs. Wang Q, Vlasova AN, Kenney SP, Saif LJ. Curr Opin Virol. 2019 Feb;34:39-49. doi: 10.1016/j.coviro.2018.12.001. Epub 2019 Jan 14. Review. PMID: 30654269
  • Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States. Yugo DM, Cossaboom CM, Heffron CL, Huang YW, Kenney SP, Woolums AR, Hurley DJ, Opriessnig T, Li L, Delwart E, Kanevsky I, Meng XJ.J Med Virol. 2019 Apr;91(4):677-686. doi: 10.1002/jmv.25339. Epub 2018 Oct 31. PMID: 30318625
  • Hepatitis E Virus: Animal Models and Zoonosis. Kenney SP, Meng XJ. Annu Rev Anim Biosci. 2019 Feb 15;7:427-448. doi: 10.1146/annurev-animal-020518-115117. Epub 2018 Oct 4. PMID: 30285462


  • Wang, Q.; Vlasova, A.N.; Kenney, S.P.; Saif, L.J. (2019). Emerging and re-emerging coronaviruses in pigs. Current Opinion in Virology, 34, 39-49. doi:10.1016/j.coviro.2018.12.001. Publication status: Accepted, issn:1879-6257
  • Kenney, S.P.; Meng, X.J. (2019). Hepatitis E Virus Genome Structure and Replication Strategy. Cold Spring Harbor perspectives in medicine, 9 (1), doi:10.1101/cshperspect.a031724. Publication status: Published, pubmed:29530948
  • Yugo, D.M.; Heffron, C.L.; Ryu, J.; Uh, K.; Subramaniam, S.; Matzinger, S.R. et al. (2018). Infection dynamics of hepatitis eVirus in wild-type and immunoglobulin heavy chain knockout JH-/- gnotobiotic piglets. Journal of Virology, 92 (21), doi:10.1128/JVI.01208-18. Publication status: Published, pubmed:30111571
  • Kenney, S.P.; Meng, X-J. (2018). Hepatitis E Virus: Animal Models and Zoonosis. Annu Rev Anim Biosci, doi:10.1146/annurevanimal-020518-115117. Publication status: Published online.
  • Li, W.; Hulswit, R.J.G.; Kenney, S.P.; Widjaja, I.; Jung, K.; Alhamo, M.A. et al. (2018). Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. Proceedings of the National Academy of Sciences of the United States of America, 115 (22), E5135-E5143. doi:10.1073/pnas.1802879115. Publication status: Published, issn:0027-8424
  • Subramaniam, S.; Overend, C.; Yugo, D.M.; Heffron, C.L.; Matzinger, S.R.; Rogers, A.J. et al. (2018). Isolation of Peripheral Blood CD8 T Cells Specific to Porcine Reproductive and Respiratory Syndrome Virus Utilizing Porcine CD137 Activation Marker. Viral immunology, 31 (4), 333-337. doi:10.1089/vim.2017.0189. Publication status: Published, pubmed:29489438
  • Yugo, D.M.; Cossaboom, C.M.; Heffron, C.L.; Huang, Y.W.; Kenney, S.P.; Woolums, A.R. et al. (2018). Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States. Journal of Medical Virology, doi:10.1002/jmv.25339. Publication status: Accepted, issn:0146-6615
  • Cao, D.; Cao, Q.M.; Subramaniam, S.; Yugo, D.M.; Lynn Heffron, C.; Rogers, A.J. et al. (2017). Pig model mimicking chronic hepatitis e virus infection in immunocompromised patients to assess immune correlates during chronicity. Proceedings of the National Academy of Sciences of the United States of America, 114 (27), 6914-6923. doi:10.1073/pnas.1705446114. Publication status: Published, issn:0027-8424
  • Piñeyro, P.E.; Subramaniam, S.; Kenney, S.P.; Heffron, C.L.; Giménez-Lirola, L.G.; Meng, X.J. (2016). Modulation of proinflammatory cytokines in monocyte-derived dendritic cells by porcine reproductive and respiratory syndrome virus through interaction with the porcine intercellular-adhesion-molecule-3-grabbing nonintegrin. Viral Immunology, 29 (10), 546-556. doi:10.1089/vim.2016.0104. Publication status: Published, issn:0882-8245


  • Cao, D.; Cao, Q.M.; Subramaniam, S.; Yugo, D.M.; Kenney, S.P., et al. (2017). Pig model mimicking chronic hepatitis e virus infection in immunocompromised patients to assess immune correlates during chronicity. Proceedings of the National Academy of Sciences of the United States of America, (27), 6914-6923. doi:10.1073/pnas.1705446114
  • Subramaniam, S.; Cao, D.; Tian, D.; Cao, Q.M.; Kenney, S.P., et al. (2017). Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs. Virus Research, 227, 212-219. doi:10.1016/j.virusres.2016.10.007
  • Co First Author-  Wentao Li, Ruben J. G. Hulswit, Scott P. Kenney, Ivy Widjaja, Raoul J. de Groot, Frank J. van Kuppeveld, Linda Saif, and Berend-Jan Bosch. (2018). Porcine deltacoronavirus can use aminopeptidase N of host and non-reservoir species as an entry receptor. Submitted to M Bio
  • Kenney, S.P.; Meng X. J. Hepatitis E virus genome structure and replication strategy. (2018). Book Chapter Cold Spring Harbor Perspectives
  • Kenney, S.P.; Meng, X.J. Animal models for hepatitis E virus infection. (2018) Annual Review of Animal Bioscience


  • Dianjun Cao, Qian M Cao, Sakthivel Subramaniam, Danielle M. Yugo, C. Lynn Heffron, Adam J. Rogers, Scott P. Kenney, Debin Tian, Shannon R. Matzinger, Christopher Overend, Nicholas Catanzaro, Tanya LeRoith, Heng Wang, Pablo Piñeyro, Nicole Lindstrom, Sherrie Clark-Deener, Lijuan Yuan, and Xiang-Jin Meng, Immunosuppression prolonged hepatitis E virus (HEV) replication via regulation of viral immune responses leading to chronic HEV infection in a pig model.  Submitted to mBio