Renukaradhya Gourapura

2020

• Garmendia, A.E, W. Mwangi and G.J. Renukaradhya. Chapter 29 – Porcine Reproductive and Respiratory Syndrome. Veterinary Vaccines for Livestock - 1st Edition, FAO9 Editors - Samia Metwally, Ahmed Elldrissi and Gerrit Viljoen, Elsevier Publication 2020.
• Renu, S, A.D. Markazi, S. Dhakal, Y.S. Lakshmanappa, R. Shanmugasundaram, R.K. Selvaraj and G.J. Renukaradhya* (2020). Oral Deliverable Mucoadhesive Chitosan-Salmonella Subunit Nanovaccine for Layer Chickens. Int J Nanomedicine, 15:761-777. PMID: 32099364.
• Hogshead, B, J. Pempek, S. Dhakal, S. Ghimire, R. Sankar, K. Proudfoot, G. Habing and G.J. Renukaradhya* (2020). Bovine parainfluenza-3 antibodies in veal calves supplemented with cinnamaldehyde or lactoferrin. Applied Animal Science, 36(1):118-123.
• Renu, S, N. Feliciano-Ruiz, S. Ghimire, Y. Han, J. Schrock, S. Dhakal, V. Patil, S. Krakowka and G.J. Renukaradhya* (2020). Poly(I:C) augments inactivated influenza virus-chitosan nanovaccine induced cellular immune response in intranasal vaccinated pigs. Vet Microbiology, 242:108611. PMID: 32122615.
• Hiremath, J, K. Tabynov and G.J. Renukaradhya* (2020). Pulmonary Inflammatory Response to Influenza Virus Infection is regulated by DAP12 and macrophage M1 and M2 phenotypes: a study in a porcine model. Cellular Immunology, 352:104078. PMID: 32164997.
• Mailybayeva, A, S. Ryskeldinova, N. Zinina, E-M, Zhou, G.J. Renukaradhya and K. Tabynov (2020). Evaluation of duration of immunogenicity and protective efficacy of improved influenza viral vector-based B. abortus vaccine against B. melitensis infection in sheep and goats. Front Vet Science, 7:58. PMID: 32175335.
• Akerele, G, N. Ramadan, S. Renu, G.J. Renukaradhya, R. Shanmugasundaram, R.K. Selvaraj (2020). In vitro characterization and immunogenicity of chitosan nanoparticles loaded with native and inactivated extracellular proteins from a field strain of Clostridium perfringens associated with necrotic enteritis. Vet Immunol Immunopathol., 224:110059. PMID: 32408182.
• Han, Y, S. Renu, V. Patil, J. Schrock, N. Feliciano-Ruiz, R. Selvaraj, and G.J. Renukaradhya* (2020). Mannose-Modified Chitosan-Nanoparticle-Based Salmonella Subunit Oral Vaccine-Induced Immune Response and Efficacy in a Challenge Trial in Broilers. Vaccines (Basel), 8(2):E299. PMID: 32545295.
• Han, Y, S. Renu, V. Patil, J. Schrock, N. Feliciano-Ruiz, R. Selvaraj, and G.J. Renukaradhya* (2020). Immune Response to Salmonella Enteritidis Infection in Broilers Immunized Orally With Chitosan-Based Salmonella Subunit Nanoparticle Vaccine. Front Immunol., 11:935. PMID: 32508828.
• Renu, S, Y. Han, S. Dhakal, Y.S. Lakshmanappa, S. Ghimire, N. Feliciano-Ruiz, S. Senapati, B. Narasimhan, R.K. Selvaraj and G.J. Renukaradhya* (2020). Chitosan-adjuvanted Salmonella subunit nanovaccine for poultry delivered through drinking water and feed. Carbohydrate Polymer, 243:116434. PMID: 32532387.
• Renu, S, N. Feliciano-Ruiz, F. Lu, S. Ghimire, Y. Han, J. Schrock, S. Dhakal, V. Patil, S. Krakowka, H. HogenEsch and G.J. Renukaradhya* (2020). A Nanoparticle-Poly(I:C) Combination Adjuvant Enhances the Breadth of the Immune Response to Inactivated Influenza Virus Vaccine in Pigs. Vaccines (Basel), 8(2):E229. PMID: 32443416.
• Han, Y, Renu, S, J. Schrock, K.Y. Acevedo-Villanuev, B. Lester, R.K. Selvaraj, and G.J. Renukaradhya* (2020). Temporal dynamics of innate and adaptive immune responses in broiler birds to oral delivered chitosan-based Salmonella subunit nanoparticle vaccine. Vet Immunol and Immunopathology, 228:110111). PMID: 32846353.
• Patil, V, S. Renu, N. Feliciano-Ruiz, Y. Han, A. Ramesh, J. Schrock, S. Dhakal, H. HogenEsch and G.J. Renukaradhya* (2020). Intranasal delivery of inactivated influenza virus and Poly(I:C) adsorbed corn-based nanoparticle vaccine elicited robust antigen-specific cell- mediated immune responses in maternal antibody positive nursery pigs. Front Immunol., 11:596964. PMID:33391267.

2019

• Garmendia, A.E, W. Mwangi and G.J. Renukaradhya. Chapter 29 – Porcine Reproductive and Respiratory Syndrome. Veterinary Vaccines for Livestock - 1st Edition, FAO. Editors - Samia Metwally, Ahmed Elldrissi and Gerrit Viljoen, Elsevier Publication 2019.
• Dhakal, S, F. Lu, S. Ghimire, S. Renu, Y.S. Lakshmanappa, B. Hogshead, D. Ragland, H., HogenEsch and G.J. Renukaradhya (2019). Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs. Nanomedicine: Nanotechnology, Biology, and Medicine, 16:226-235. PMID: 30611772, IF – 5.005.
• Nurpeisova, A, M. Kassenov, N. Rametov, K. Tabynov, G. J. Renukaradhya, Y. Volgin, A. Sagymbay, G. Sarsenbayeva, N. Bogdanov, T. Isagilov, A. Makbuz, A. Sansyzbay and B. Khairullin (2019). Analysis of Efficacy of Adjuvant-based Inactivated Pandemic H5N1 Influenza Virus Vaccine. Archives of Virology, 164(4):1027-1036, IF – 2.261.
• Dhakal, S, L. Wang, L. Antony, J. Rank, P. Bernardo, S. Ghimire, K. Bondra, C. Siems, Y.S. Lakshmanappa, S. Renu, B. Hogshead, S. Krakowka, M. Kauffman, J. Scaria, J.T. LeJeune, Z. Yu and G.J. Renukaradhya (2019). Amish (Rural) vs. non-Amish (Urban) Infant Fecal 6 Microbiotas Are Highly Diverse and Their Transplantation Lead to Differences in Mucosal Immune Maturation in a Humanized Germfree Piglet Model. Frontiers in Immunology, 10:1509. PMID: 31379808, IF – 5.511.
• Dhakal, S, K.A. Ross, S. Ghimire, Y.S. Lakshmanappa, B. Hogshead, P. Bernardo, C.W. Lee, M.J. Wannemuehler, B. Narasimhan and G.J. Renukaradhya (2019). Evaluation of CpG-ODN-adjuvanted polyanhydride-based intranasal influenza nanovaccine in pigs. Veterinary Microbiology, 226:23-30. PMID: 31585639, IF – 2.524.
• Renu, S, A.D. Markazi, S. Dhakal, Y.S. Lakshmanappa, R. Shanmugasundaram, R.K. Selvaraj and G.J. Renukaradhya (2019). Formulation of oral mucoadhesive chitosan-Salmonella subunit nanovaccine for layer birds. International Journal of Nanomedicine (In Press). IF – 4.370.
• Hogshead, B, J. Pempek, S. Dhakal, S. Ghimire, R. Sankar, K. Proudfoot, G. Habing and G.J. Renukaradhya (2019). Bovine parainfluenza-3 antibodies in veal calves supplemented with cinnamaldehyde or lactoferrin. Applied Animal Science (In Press).

2018

• Garmendia, A.E, W. Mwangi and G.J. Renukaradhya. Chapter 29 – Porcine Reproductive and Respiratory Syndrome. Veterinary Vaccines for Livestock - 1st Edition, FAO. Editors - Samia Metwally, Ahmed Elldrissi and Gerrit Viljoen, Elsevier Publication 2018. 
• Liu, J, R.M. Gallo, M. Khan, G.J. Renukaradhya and R.R. Brutkiewicz (2018). Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T Cell Lymphoma. Front. Immunol., 8:1901. PMID: 29354122, IF – 5.511. 
• Li, Y, P. Shang, C. Carrillo, P. Naraghi-Arani, C.J. Jain, G.J. Renukaradhya, A.W. Firth, E.J. Snijder and Y. Fang* (2018). Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses. Virology, 517:164-176. PMID: 29325778, IF – 3.374. 
• Renu, S, S. Dhakal, E. Kim, J. Goodman, Y.S. Lakshmanappa, M.J. Wannemuehler, B. Narasimhan, P.B. Boyaka, and G.J. Renukaradhya (2018). Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine. Cellular Immunology, 329:27-30. PMID: 29665972, IF – 2.995. 
• Dhakal, S, S. Renu, S. Ghimire, Y.S. Lakshmanappa, B. Hogshead, N.F. Ruiz, F. Lu, H. HogenEsch, S. Krakowka, C.W. Lee and G.J. Renukaradhya (2018). Mucosal immunity and protective efficacy of intranasal inactivated influenza vaccine is improved by chitosan nanoparticle delivery in pigs. Frontiers in Immunology, 9:934. PMID: 29770135, IF – 5.511.
• Dhakal, S, X. Cheng, J. Salcido, S. Renu, K. Bondra, Y.S. Lakshmanappa, C. Misch, S. Ghimire, N.F. Ruiz, B. Hogshead, S. Krakowka, K. Carson, J. McDonough, C.W. Lee and G.J. Renukaradhya (2018). Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs. International Journal of Nanomedicine, 13:6699-6715. PMID: 30425484, IF – 4.370. 
• Zhugunissov, K, Y. Bulatov, D. Taranov, Z. Yershebulov, Z. Koshemetov, A. Zhunushov, G.J. Renukaradhya, K. Tabynov and Y. Abduraimov (2018). Beta-propiolactone inactivated bivalent bluetongue virus vaccine containing Montanide ISA-71VG adjuvant induces long-term immune response in sheep against serotypes 4 and 16 even after 3 years of controlled vaccine storage. Veterinary Microbiology, 226:23-30. PMID: 30389040, IF – 2.524. 
• Guo R, P. Shang P, C.A. Carrillo, Z. Sun, Y.S. Lakshmanappa, X. Yan, G.J. Renukaradhya, J. McGill, C.J. Jaing, M.C. Niederwerder, R.R.R. Rowland and Y. Fang (2018). Double-stranded viral RNA persists in vitro and in vivo during prolonged infection of porcine reproductive and respiratory syndrome virus. Virology, 524:78-89. PMID: 30165309, IF – 3.374. 
• Renu, S, A.D. Markazi, S. Dhakal, Y.S. Lakshmanappa, S.R. Gourapura, R. Shanmugasundaram, S. Senapati, B. Narasimhan, R.K. Selvaraj and G.J. Renukaradhya (2018). Surface engineered polyanhydride based oral Salmonella subunit nanovaccine for poultry. International Journal of Nanomedicine, 13:8195-8215. PMID: 30555234, IF – 4.370. Dhakal, S, F. Lu, S. Ghimire, S. Renu, Y.S. Lakshmanappa, B. Hogshead, D. Ragland, H., HogenEsch and G.J. Renukaradhya (2018). Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs. Nanomedicine, pii: S1549-9634(18)30570-7. doi: 10.1016/j.nano.2018.12.003. PMID: 30611772, IF – 5.005

2017

• Garmendia, A.E, W. Mwangiand Gourapura, R.J. Chapter 29 –Porcine Reproductive and Respiratory Syndrome. Veterinary Vaccines for Livestock -1st Edition, FAO. Editors -Samia Metwally, Ahmed Elldrissi and Gerrit Viljoen, Elsevier Publication 2018.
• Mailybayeva, A.; Yespembetov, B.; Ryskeldinova, S.; Zinina, N.; Gourapura, R.J.; Petrovsky, N.; Tabynov, K. (2017). Improved influenza viral vector based Brucella abortus vaccine induces robust B and T-cell responses and protection against Brucella melitensis infection in pregnant sheep and goats. PLOS ONE, (10), e0186484-e0186484. doi:10.1371/journal.pone.0186484 Publication status: Published, Percent of authorship: 10%, Description of effort:  Analyzed the results and edited the manuscript. Impact factor -2.806.
• Dhakal, S.; Goodman, J.; Bondra, K.; Lakshmanappa, Y.S.; Gourapura, R.J. (2017). Polyanhydride nanovaccine against swine influenza virus in pigs. Vaccine, (8), 1124-1131. doi:10.1016/j.vaccine.2017.01.019
• Publication status: Published, Percent of authorship: 50%, Description of effort:  Designed the research, performed the experiments, analyzed the results and edited the manuscript. Impact factor -3.235.
• Elaish, M.; Ngunjiri, J.M.; Ali, A.; Xia, M.; Gourapura, R.J. (2017). Supplementation of inactivated influenza vaccine with norovirus P particle-M2e chimeric vaccine enhances protection against heterologous virus challenge in chickens. PloS one, (2), e0171174. doi:10.1371/journal.pone.0171174. Publication status: Published, Percent of authorship: 10%, Description of effort: Analyzed the results and edited the manuscript. Impact factor -2.806.
• Dhakal, S, J. Hiremath, K. Bondra, Y.S. Lakshmanappa, D. Shyu, K. Oyuang, K. Kang, B. Binjawadagi, J. Goodman, K. Tabynov, S. Krakowka, B. Narasimhan, C.W. Lee and Gourapura, R.J. (2017). Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs. Journal of Controlled Release, 247, 194-205. Publication status: Published, Percent of authorship: 50%, Description of effort: Designed the experiments, performed the study, analyzed the results and edited the manuscript. Impact factor -7.441.
• Renur, OMarkazi, A.D.; Selvaraj, R.; Gourapura, R.J. (2017). Engineering of Targeted Mucoadhesive Chitosan Based Salmonella Nanovaccine for Oral Delivery in Poultry. Manuscript Submitted.
• Dhakal, S.; Cheng, X.; Salcido, J.; Lee, C.W.; Gourapura, R.J.  (2017). Liposome nanoparticle-based influenza conserved peptides vaccine and monosodium urate crystal adjuvant elicits protective immune response in pigs. Manuscript under Revision.

2016

• Tabynov, K, B. Yespembetov, N. Matikhan, S. Ryskeldinova, N. Zinina, Z. Kydyrbayev, N. Assanzhanova, K. Tabynov, G.J. Renukaradhya and A. Sansyzbay, "First evaluation of an influenza viral vector based Brucella abortus vaccine in sheep and goats: assessment of safety, immunogenicity and protective efficacy against Brucella melitensis infection.". Vet. Microbiology. Vol. 197, 15-20. 2016. (Published) 25% Authorship: 25% Authorship. Analyzed the results and edited the manuscript. Impact factor - 2.511
• Tabynov, K, M. Orynbayev, G.J. Renukaradhya and A. Sansyzbay, "Simultaneous subcutaneous and conjunctival administration of the influenza viral vector Brucella abortus vaccine to pregnant heifers provides better protection against B. abortus 544 infection than the commercial B. abortus S19 vaccine.". Vaccine. Vol. 34, no. 42: 5049-52. 2016. (Published) 25% Authorship: 25% Authorship. Analyzed the results and edited the manuscript. Impact factor - 3.413
• Tabynov, K, Sansyzbay A, Tulemissova, Z, Dhakal, S, Renukaradhya, GJ, and Mambetaliyev, M, "Inactivated porcine reproductive and respiratory syndrome virus vaccine adjuvanted with MontanideTM Gel 01 ST elicits virus-specific cross-protective inter-genotypic response in piglets". Veterinary Microbiology. Vol. 192, 81-89. 2016. (Published) 50% Authorship: Analyzed the results and edited the manuscript. Impact factor - 2.511.
• Dwivedi V, C. Manickam, S. Dhakal, B. Binjawadagi, K. Oyuang, J. Hiremath, M. Khatri, J. Gervey-Hague, C-W. Lee, and G.J. Renukaradhya, "Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs". Veterinary Microbiology. Vol. 186, 157-163. 2016. (Published) 50% Authorship: Designed the experiments, performed the study, analyzed the results and edited the manuscript. Impact factor - 2.511.
• Hiremath J, Kyung-il K, Elaish M, Binjawadagi B, Ouyang K, Dhakal S, Torrelles JB, Lee C-W, and Renukaradhya GJ, "Entrapment of H1N1 influenza virus derived conserved peptides in PLGA nanoparticles enhances T cell response and vaccine efficacy in pigs". PLOS One. Vol. 11, no. 4: e0151922. 2016. (Published) 50% Authorship: Designed the experiments, performed the study, analyzed the results and edited the manuscript. Impact factor - 3.234.
• Ouyang, K, J. Hiremath, B. Binjawadagi, D-L. Shyu, S. Dhakal, J. Arcos, R. Schleappi, L. Holman, M. Roof, J.B. Torrelles, and G.J. Renukaradhya, "Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study". Veterinary Research. Vol. 47, no. 1: 45. 2016. (Published) 50% Authorship: Designed the experiments, performed the study, analyzed the results and edited the manuscript. Impact factor - 2.82.
• Yanhua, L, Shyu, D-L, Shang, P, Bai, J, Ouyang, K, Dhakal, S, Hiremath, JH, Binjawadagi, B, Renukaradhya, GJ, and Fang, Y., "Mutations in a highly conserved motif of nsp1β protein attenuate the innate immune suppression function of porcine reproductive and respiratory syndrome virus (PRRSV)". Journal of Virology. Vol. 90, no. 7: 3584-3599. 2016. (Published) 50% Authorship: Corresponding authors: Renukaradhya, G.J., and Fang, Y. Designed the experiments, performed part of the study, analyzed the results and edited the manuscript. Impact factor - 5.076.

2015

• Thomas, M, Wang, Z, Sreenivasan, CC, Hause, BM, Renukaradhya, GJ, Li, F, Francis, DH, Kaushik, RS, Khatri, M., "Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs". Vaccine. Vol. 33, no. 4: 542-548. 2015.
• Ouyang, K, Shyu, D-L, Dhakal, S, Hiremath, J, Binjawadagi, B, Yashavanth, SL, Guo, R, Ransburgh, R, Bondra, KM, Gauger, P, Zhang, J, Specht, T, Gilbertie, A, Minton, W, Fang, Y, and Renukaradhya, GJ., "Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditions". Veterinary Research. Vol. 46, no. 1: 140. 2015.
• Renukaradhya, GJ, Meng, X-J, Calvert, JG, Roof, M, and Lager, KM., "Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction". Review of Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome, by Veterinary vaccine researchers. Vaccine. Vol. 33, no. 27:
• 3065-3072. (2015).
• Renukaradhya, GJ, Meng, X-J, Calvert, JG, Roof, M, and Lager, KM., "Live porcine reproductive and respiratory syndrome virus-based vaccines: current status and future direction". Review of Live porcine reproductive and respiratory syndrome virus candidate vaccines, by Veterinary vaccine researchers. Vaccine. Vol. 33, no. 33: 4069- 4080. (2015).
• Lunney, JK, Fang, Y, Ladinig, A, Chen, N, Li, Y, Rowland, B, and Renukaradhya, GJ., "Porcine reproductive and respiratory syndrome virus (PRRSV): Pathogenesis and Interaction with the Immune System". Review of PRRSV Pathogenesis and Interaction with the Immune System, by Particulate vaccine delivery researchers. Annual Review of Animal Biosciences. Vol. 14, 25. (2015).
• Renukaradhya, GJ, Narasimhan, B, and Mallapragada, SK, "Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation". Review of Nanoparticle based vaccine delivery system in animal models, by Particulate vaccine delivery researchers. Journal of Control Release. Vol. 219, 622-631. (2015)