People

David A. Benfield

MS, PhD

Professor Emeritus

Contact

benfield.2@osu.edu (330) 263-3703 Ohio Agricultural Research & Development Center
1680 Madison Ave.
Wooster, OH 44691
Map Link

Department

Veterinary Preventive Medicine

Professional Training and experience

  • MS, Purdue University
  • PhD, University of Missouri-Columbia

Research Interests

  • Molecular and cellular mechanisms by which positive stranded RNA viruses alter the metabolism of host cells and how these viruses mediate persistence

Research Summary

  • Molecular and cellular mechanisms by which positive stranded RNA viruses alter the metabolism of host cells and how these viruses mediate persistence. As a model for our studies, our laboratory is focused on the order Nidovirales (coronaviruses and arteriviruses), using the porcine arterivirus, porcine reproductive and respiratory disease virus

Professional Service

  • Editorial Board for Journal of Veterinary Diagnostic Investigation (1998-2006)
  • Co-chairperson of the Diagnostic Virology Subcommittee of the American Association of Veterinary Laboratory Diagnosticians (2000-2005)

Publications

Peer Reviewed Articles

(partial listing)

  • Ropp SR, Y Fang, CE Wees, EA Nelson, KD Rossow, M Bien, B Arndt, S Preszler, P Steen, J Christopher-Hennings, JE Collins, DA Benfield and KS Faaberg. 2004. Antigenic and genetic characterization of emerging European-like PRRSV isolates in the United States. J. Virol 78:3684-3703.
  • Rowland RRR, P Schneider, Y Fang, S Wooton, D Yoo and DA Benfield. 2003. Peptide domains involved in the localization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus. Virology 316:135-145.
  • Rowland RRR, S Lawson, K Rossow and DA Benfield. 2003. Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero. Veterinary Microbiology 96:219-235.
  • Benfield D, J Christopher-Hennings, J Collins, S Dee, W Mengeling, K Rossow and J Zimmerman. 2002. Porcine reproductive and respiratory syndrome (PRRS). Swine Industry Handbook, Purdue University Cooperative Extension Service, West Lafayette, Indiana.
  • Kim TS, DA Benfield and RRR Rowland. 2002. Porcine reproductive and respiratory syndrome virus-induced cell death exhibits features consistent with non-typical apoptosis. Virus Research 85:133-140.
  • Christopher-Hennings J, LD Holler, DA Benfield, EA Nelson. 2001. Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J Vet Diag Invest 13:133-142.
  • Feng W-H, SM Laster, M Tompkins, T Brown, J-S Xu, C Altier, W Gomez, D Benfield and M McCaw. 2001. In Utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility to piglets to challenge by Streptococcus suis type II. J Virol 75:4889-4895.
  • Rowland, RRR, B Robinson, J Stefanick, TS Taeg, L Guanghua, SR Lawson and DA Benfield. 2001. Inhibition of porcine reproductive and respiratory syndrome virus by interferon-gamma and recovery of virus replication with 2-aminopurine. Arch Virol 146:539-555.