People

Vanessa L. Hale

DVM, MAT, PhD

Associate Professor

Contact

(614) 247-8377 Sisson Hall
1920 Coffee Road
Columbus, OH 43210
Map Link

Department

Veterinary Preventive Medicine

Related Links

Professional Training and Experience

  • PhD, Purdue University - Ecology, Evolution, Environmental Biology 
  • DVM, Purdue University - College of Veterinary Medicine
  • MA, Western New Mexico University - Teaching, Secondary Education
  • BS, University of Georgia - Biology
  • BA, University of Georgia, English, Chinese minor

Research Interests

  • Role of the gut microbiome in disease prevention, diagnosis, and treatment
  • Gut microbial dynamics and colonization resistance in infectious disease
    • Clostridiodes difficile infection
  • Colobine monkey gut microbial ecology

Publications

  • Mrofchak R, Madden C,  Evans MV, Kisseberth WC, Dhawan D, Knapp DK, Hale VL. Urine and Fecal Microbiota in a Canine Model of Bladder Cancer. All Life. 2022 15:1, 1245-1263, DOI: 10.1080/26895293.2022.2154858
  • Minich D, Madden C, Navarro MA, Glowacki L, French-Kim K, Chan W, Evans MV, Soares K, Mrofchak R, Madan R, Ballash GA, LaPerle K, Paul S, Vodovotz Y, Uzal FA, Martinez M, Hausmann J, Junge RE, Hale VL. Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care. Anim Microbiome. 2022 Jan 9;4(1):7. doi: 10.1186/s42523-021-00148-7. PMID: 35000619; PMCID: PMC8744333.
  • Amato KR, Clayton JB, Hale VL. 2022 The colobine gut microbiota: New perspectives on the nutrition and health of a specialized subfamily of primates. In I Matsuda, CC Grueter, JA Teichroeb (Eds.).The Colobines: Natural History, Behaviour and Ecological Diversity. (pp. 78-93). Cambridge University Press.
  • Hale VL, Dennis PM, McBride DS, Nolting JM, Madden C, Huey D, Ehrlich M, Grieser J, Winston J, Lombardi D, Gibson S, Saif L, Killian ML, Lantz K, Tell RM, Torchetti M, Robbe-Austerman S, Nelson MI, Faith SA, Bowman AS. SARS-CoV-2 infection in free-ranging white-tailed deer. Nature. 2022 Feb;602(7897):481-486. doi: 10.1038/s41586-021-04353-x. Epub 2021 Dec 23. PMID: 34942632; PMCID: PMC8857059.
  • Bernard K, Davis A, Simpson IM, Hale VL, Lee J, Winston RJ. Detection of SARS-CoV-2 in urban stormwater: An environmental reservoir and potential interface between human and animal sources. Sci Total Environ. 2022 Feb 10;807(Pt 3):151046. doi: 10.1016/j.scitotenv.2021.151046. Epub 2021 Oct 18. PMID: 34673059; PMCID: PMC8522674.
  • V.L. Hale, P.M. Dennis, D.S. McBride, J.M. Nolting, C. Madden, D. Huey, M. Ehrlich, J. Grieser, J.A. Winston, D. Lombardi, S. Gibson, L. Saif, M.L. Killian, K. Lantz, R.M. Tell, M.K. Torchetti, S. Robbe-Austerman, M.I. Nelson, S.A. Faith, A. Bowman. SARS-CoV-2 infection in free-ranging white-tailed deer (Odocoileus virginianus). Nature. 602: 481-486. DOI: 10.1038/s41586-021-04353-x. 40% Authorship. I obtained funding to support this project, coordinating testing and sampling efforts, and drafted the manuscript.
  • D. Minich, C. Madden, M.A. Navarro, L. Glowacki, K. French-Kim, W. Chan, M.V. Evans, K. Soares, R. Mrofchak, R. Madan, G.A. Ballash, K. LaPerle, S. Paul, Y. Vodovotz, F.A. Uzal, M. Martinez, J. Hausmann, R.E. Junge, V.L. Hale. 2022. Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care. Animal Microbiome. 4:7. DOI: 10.1186/s42523-021-00148-7. 50% Authorship. I oversaw the analysis, guided the direction of the project, obtained funding to support this project, and wrote portions of the manuscript.
  • K. Bernard, A. Davis, I.M. Simpson, V.L. Hale, J. Lee, R.J. Winston. 2022. Detection of SARS-CoV-2 in urban stormwater: An environmental reservoir and potential interface between human and animal sources. Science of the Total Environment. 807: 15104. DOI: 10.1016/j.scitotenv.2021.151046. 7% Authorship. I secured funding for this project and helped oversee this work as part of the larger eSCOUT effort. I also edited the manuscript.
  • K. Soares, C.J. Bruno de Oliveira, A.E. Rodrigues, P.C. Vasconcelos, N.M. Vieira da Silva, O.G.C. Filho, C. Madden, V.L. Hale. Tetracycline exposure alters key gut microbiota in Africanized honey bees (Apis mellifera scutellata x spp). Frontiers in Ecology and Evolution. Special Issue: Impact of Anthropogenic Environmental Changes on Animal Microbiomes. 9:716660. DOI: 10.3389/fevo.2021.716660. 50% Authorship. I oversaw the analysis, guided the direction of the project, and wrote portions of the manuscript.
  • A.G. Arruda, L. Deblais, V. Hale, M. Pairis-Garcia, V. Srivastava, D. Kathayat, A. Kumar, G. Rajashekara. Nasal and gut microbiota for sows of different health status within six commercial swine farms from one swine production system. PeerJ. 9:e12120. DOI: 10.7717/peerj.12120 30% Authorship. I directly analyzed or oversaw all microbial community analysis and interpretation and wrote several portions of the manuscript.
  • R. Mrofchak, C. Madden, M.V. Evans, V.L. Hale. 2021. Evaluating extraction methods to study canine urine microbiota. PLOS One. 16(7): e0253989. DOI: 10.1371/journal.pone.0253989.  50% Authorship. I conceived of this project and coordinated sample collection, extraction, and oversaw analysis lead by Masters student R. Mrofchak.
  • D. Minich#, C. Madden, M.V. Evans, G.A. Ballash, D.J. Barr, K.P. Poulsen, P.M. Dennis, V.L. Hale. 2021. Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (Odocoileus virginianus). Scientific Reports. 11: 13218. DOI: 10.1038/s41598-021-89896-9. 50% Authorship. I conceived of this project and coordinated sample collection, extraction, oversaw analysis by veterinary student D. Minich, and wrote portions of the manuscript.
  • V.L. Hale. 2021. mSphere of Influence: Drivers of Host-Associated Microbial Community Structure and Change. mSphere. 6. DOI: 10.1128/mSphere.00248-21. 100% Contribution. I conceived of and wrote this manuscript.
  • A.M. Antonson, M.V. Evans, J.D. Galley, H.J. Chen, T.A. Rajasekera, S.M. Lammers, V.L. Hale, M.T. Bailey, T.L. Gur. 2020. Unique maternal immune and functional microbial profiles during prenatal stress. Scientific Reports. 10: 20288. DOI: 10.1038/s41598-020-77265-x.
  • M. Kim, E. Vogtmann, D.A. Ahlquist, M.E. Devens, J.B. Kisiel, W.R. Taylor, B.A. White, V.L. Hale, J. Sung, N. Chia, R. Sinha, J. Chen. 2020. Fecal metabolomic signatures in colorectal adenoma patients are associated with gut microbiota and early events of colorectal cancer pathogenesis. mBio. 11:1. DOI: 10.1128/mBio.03186-19.
  • J.C. Yu, V.L. Hale, H. Khodadadi, B. Baban. 2019. Whole body vibration-induced omental macrophage polarization and fecal microbiome modification in a murine model. International Journal of Molecular Sciences. 20: 3125. DOI: 10.3390/ijms20133125
  • V.L. Hale, C.L. Tan, K. Niu, Y. Yang, Q. Zhang, R. Knight, K.R. Amato. 2019. Gut microbiota in wild and captive Guizhou snub-nosed monkeys, Rhinopithecus brelichi. American Journal of Primatology. 8: e22989. DOI: 10.1002/ajp.22989.
  • G.B. Saffouri, R. Shields-Cutler, J. Chen, Y. Yang, H.R. Lekatz, V.L. Hale, J.M. Cho, E.J. Battaglioli, Y. Bhattarai, K.J. Thompson, K.K. Kalari, G. Behera, J.C. Berry, S.A. Peters, R. Patel, A.N. Schuetz, J.J. Faith, M. Camilleri, J.L. Sonnenburg, G. Farrugia, J.R. Swann, M. Grover, D. Knights, P.C. Kashyap. 2019. Small intestinal microbial composition is more relevant than quantitative small intestinal culture in patients with gastrointestinal symptoms. Nature Communications. 10: 2012. DOI: 10.1038/s41467-019-09964-7.
  • G.M. Sindberg, S.E. Callen, S. Banerjee, J. Meng, V.L. Hale, R. Hegde, P.D. Cheney, S. Buch, S. Roy. 2019. Morphine potentiates dysbiotic microbial and metabolic shifts in SIV infection. Journal of Neuroimmune Pharmacology: 14:200-2014. DOI: 10.1007/s11481-018-9805-6.
  • V.L. Hale, P. Jeraldo, J. Chen, M. Mundy, J. Yao, S. Priya, G. Keeney, K. Lyke, J. Ridlon, B.A. White, A.J. French, S. Thibodeau, C. Diener, O. Resendis-Antonio, J. Gransee, T. Dutta, X.M. Petterson, R. Blekhman, L. Boardman, D. Larson, H. Nelson, N. Chia. Distinct Microbes, Metabolites, and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers. Genome Medicine. 10:78. *co-first author. Altmetric: 28.
  • E.J. Battaglioli, V.L. Hale, J. Chen, P. Jeraldo, C. Ruiz Mojica, B.A. Schmidt, V.M. Rekdal, L.M. Till, L. Huq, S.A. Smits, W.J. Moor, Y. Jones-Hall, T. Smyrk, S. Khanna, D.S. Pardi, M. Grover, R. Patel, N. Chia, H. Nelson, J.L. Sonnenburg, G. Farrugia, P.C. Kashyap. Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea. Science Translational Medicine. 10:eaam7019. *co-first author Altmetric: 143.
  • G.M. Sindberg, S.E. Callen, S. Banerjee, J. Meng, V.L. Hale, R. Hegde, P.D. Cheney, S. Buch, S. Roy. 2018. Morphine potentiates dysbiotic microbial and metabolic shifts in SIV infection. Journal of Neuroimmune Pharmacology. Accepted. Altmetric: 4.
  • J.C. Yu, H. Khodadadi, A. Malik, B. Davidson, E. dS.L. Salles, J. Bhatia, V.L. Hale, B. Baban. Innate Immunity of Neonates and Infants: The status of Innate Lymphoid Cells. Frontiers in Immunology. 9:1759. Altmetric: 6.
  • V.L. Hale, P. Jeraldo, M. Mundy, J. Yao, G. Keeney, N. Scott, H. Cheek, J. Davidson, M. Green, C. Martinez, J. Lehman, C. Pettry, E. Reed, K. Lyke, B.A. White, C. Diener, O. Resendis-Antonio, J. Gransee, T. Dutta, X.M. Persson, L.A. Boardman, D. Larson, H. Nelson, N. Chia. Synthesis of multi-omic data and community metabolic models reveals insights into the role of hydrogen sulfide in colon cancer. Methods. 149:59-68. Altmetric: 2.
  • V.L. Hale, C.L. Tan, K. Niu, Y. Yang, R. Knight, Q. Zhang, D. Cui, K.R. Amato. Diet vs. Phylogeny: A comparison of gut microbiota in captive colobine monkey species.  Microbial Ecology. 75:515-527. Altmetric: 13.
  • J.M. Allen, L.J. Mailing, J. Cohrs, C. Salmonson, J. Fryer, N. Vandana, MD, V.L. Hale, P. Kashyap, B. White, J.A. Woods. Exercise training-induced modifications of the gut microbiota can mediate host response to microbial colonization and colitis insult in gnotobiotic mice. Gut Microbes. 9:115-130. Altmetric: 141.
  • L.R. Thompson, J.G. Sanders, D. McDonald et al. & the Earth Microbiome Project Consortium (300+ authors including V. Hale). 2017. A communal catalogue reveals Earth’s multiscale microbial diversity. Nature. 551:457-463: DOI: 0.1038/nature24621.
  • J.M. Allen, L.J. Mailing, J. Cohrs, C. Salmonson, J. Fryer, N. Vandana, MD, V.L. Hale, P. Kashyap, B. White, 
J.A. Woods. 2017. Exercise training-induced modifications of the gut microbiota can mediate host response to microbial colonization and colitis insult in gnotobiotic mice. Gut Microbes. In Press: DOI: 10.1080/19490976.2017.1372077.
  • E.J. Battaglioli*, V.L. Hale*, J. Chen, P. Jeraldo, C. Ruiz Mojica, V.M. Rekdal, L. Huq, S.A. Smits,Y. Jones-Hall, T. Smyrk, S. Khanna, D.S. Pardi, M. Grover, R. Patel, N. Chia, H. Nelson, J.L. Sonnenburg, G. Farrugia, P.C. Kashyap Clostridioides difficile exploits a metabolic niche associated with dysbiosis in patients with diarrhea. Science Translational Medicine. Second revision submitted January 2018. *co-first author
  • Sindberg, G.M., S.E. Callen, S. Banerjee, J. Meng, V.L. Hale, R. Hegde, P.D. Cheney, S. Buch, S. Roy. Morphine potentiates dysbiotic microbial and metabolic shifts in SIV infection. mSystems. Under review.
  • V.L. Hale, P. Jeraldo, M. Mundy, J. Yao, G. Keeney, N. Scott, H. Cheek, J. Davidson, M. Green, C. Martinez, J. Lehman, C. Pettry, E. Reed, K. Lyke, B.A. White, C. Diener, O. Resendis-Antonio, J. Gransee, T. Dutta, X.M. Persson, L.A. Boardman, D. Larson, H. Nelson, N. Chia. Synthesis of multi-omic data and community metabolic models reveals insights into the role of hydrogen sulfide in colon cancer. Methods. Submitted October 2017. Under review.