People

Haichang Li

DVM, PhD

Assistant Professor

Contact

li.3714@osu.edu 614-247-5703 Veterinary Medicine Academic Building
1900 Coffey Road
Columbus, OH 43210
Map Link

Department

Veterinary Biosciences

Professional Training and experience

  • Assistant Professor, The Ohio State University College of Veterinary Medicine, OH
  • Research Assistant Professor, The Ohio State University Wexner Medical Center, OH
  • Research and Teaching Specialist, Rutgers-Robert Wood Johnson Medical School, NJ
  • Research Scientist, RIKEN-Brain Science Institute (BSI), Japan
  • PhD, Molecular Biology and Genetics, Gifu University, Japan
  • MS, Physiology and Biochemistry, Beijing Agricultural University, China
  • BA, Veterinary Science, Henan Agricultural University, China

Research Interests

  • Cell signaling, protein-protein interaction, and cancer biology
  • Tumor suppressors in lung cancer and other solid tumors
  • Drug/Chemo-resistances
  • Tissue repair and regenerative medicine
  • Neuroprotection and neurodegenerative diseases
  • Translational medicine

Selected Awards and Honors

  • Butler-Williams Scholars of NIH/NIA, 2020
  • Lockwood Early Faculty Career Development Award, OSU, 2015
  • Early Career Award for Spinal Cord Research, 2009
  • Core Research for Evolutionary Science and Technology Fellow, Japan, 2001
  • Rotary Yoneyama Memorial Foundation Scholarship, Japan,1999

Professional Services

  • Associate Editor, Frontiers in Pharmacology
  • Section Editor, Recent Patents on Anti-Cancer Drug Discovery
  • Topic Editor, Frontiers in Oncology/Pharmacology
  • Reviewer Editor, Frontiers in Oncology/Pharmacology/Physiology

Publications

Complete List of Published Work in MyBibliography:  https://www.ncbi.nlm.nih.gov/myncbi/1pKFYXLGcfpco5/bibliography/public/

  • Li Zhao, Dong-Hua Yang, and Haichang Li (Corresponding author) (2022). Editorial: New Modalities in Cancer Diagnostics and Therapeutics. Front. Pharmacol.  13: 1101506.  PMID: 36532765. DOI: https://doi.org/10.3389/fphar.2022.1101506.
  • Haichang Li, Pu Duann, Zhongguang Li, Xinyu Zhou, Jianjie Ma, Brad H. Rovin, Pei-Hui Lin (2022). The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis. Kidney International. 101(1):119-130. PMID: 34757120. DOI: 10.1016/j.kint.2021.09.027. 
  • Pranav Gupta, Haichang Li (Co-corresponding author), Guan-nan Zhang, Anna Maria Barbuti, Pei-hui Lin, Chuanxi Cai, Tao Tan, Jianjie Ma, Zhe-Sheng Chen (2022). MG53 inhibits cellular proliferation and tumor progression in doxorubicin-resistant colorectal adenocarcinoma. Int. J. Biol. Sci. 18(14): 5221-5229. DOI: 10.7150/ijbs.67869.
  • Hong Niu, Haichang Li (Co-first author), Ya Guan, Zhongguang Li, Serena li Zhao, Pei-Hui Li, Peng Chen, Tao Tan, Hua Zhu, Valerie Bergdall, Jianjun Guan, and Jianjie Ma (2022).Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development. Bioact, Mater. 18(1):104-115. PMCID: PMC8961467 DOI: 10.1016/j.bioactmat.2022.03.017.
  • Haichang Li, Lucia Rosas, Zhongguang Li, Zehua Bian, Xiuchun Li, Kyounghan Choi, Chuanxi Cai, Xinyu Zhou, Tao Tan, Valerie Bergdall, Bryan Whitson, Ian Davis and Jianjie Ma (2022). MG53 attenuates nitrogen mustard-induced acute lung injury. J. Cell. Mol. Med. 26(7):1886-1895. PMCID:PMC8980905. DOI: https://doi.org/10.1111/jcmm.16917.
  • Haichang Li (Co-corresponding author), Pei-Hui Lin, Pranav Gupta, Xiangguang Li, Li Zhao, Xinyu Zhou, Zhongguang Li, Shengcai Wei, Jing Lu, Tao Tan, Dong-Hua Yang, Zhe-Sheng Chen, Timothy M. Pawlik, Robert E. Merritt, and Jianjie Ma (2021). MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Mol. Cancer. 20(1):118. PMCID: PMC8439062. DOI:10.1186/s12943-021-01418-3.
  • Haichang Li (Co-corresponding author), Li Zhao, Pascale Cohen, Dong-Hua Yang (2021). Editorial: New Technologies in Cancer Diagnostics and Therapeutics. Front. Pharmacol. 12:760833. PMCID: PMC8450445. DOI: 10.3389/fphar.2021.760833.
  • Adam Kenney, Zhongguang Li, Zehua Bian, Xinyu Zhou, Haichang Li, Bryan Whitson, Tan Tan, Chuanxi Cai, Jianjie Ma, and Jacob Yount (2021). Recombinant MG53 protein protects mice from lethal influenza virus infection. Am. J. Respir. Crit. Care Med. 203(2):254-257. PMCID:33031705. DOI: 10.1164/rccm.202007-2908LE.
  • Bryan A Whitson, Kristine Mulier, Haichang Li , Xinyu Zhou , Chuanxi Cai, Sylvester M Black, Tao Tan, Jianjie Ma, Greg J Beilman (2021). MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury. Mil. Med. 186:339-345. PMCID: 33499468. DOI: 10.1093/milmed/usaa313.
  • Matthew Sermersheim, Adam Kenney, Pei-Hui Lin, Temet McMichael, Chuanxi Cai, Kristyn Gumpper, T.M. Ayodele Adesanya, Haichang Li, Xinyu Zhou, Ki Ho Park, Jacob Yount, and Jianjie Ma (2020). MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. Nat Commun. 11(1):3624. PMCID: PMC7368064. DOI:10.1038/s41467-020-17177-6.
  • Chao Liu, Yun-hui Hu, Yu Han, Yong-bin Wang, Yan Zhang, Xiao-qun Zhang, Duo-fen He, Hong-mei Ren, Yu-kai Liu, Hong-yong Wang, Tao Tan, Pei-hui Lin, Haichang Li, Brad H. Rovin4, Jian-jie Ma and Chun-yu Zeng (2020). MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis. Acta Pharmacol. Sin. 41(11):1457-1464. PMCID: PMC7656601. DOI: 10.1038/s41401-020-0420-8.
  • Qiang Wang, Zehua Bian, Qiwei Jiang, Xiaoliang Wang, Xinyu Zhou, Ki Ho Park, Willa Hsueh, Bryan A. Whitson, Erin Haggard, Haichang Li, Ken Chen, Chuanxi Cai, Tao Tan, Hua Zhu, Jianjie Ma (2020). MG53 does not manifest the development of diabetes in db/db mice. Diabetes. 69(5):1052-1064. PMCID:PMC7171965. DOI: 10.2337/db19-0807.
  • Zehua Bian , Qiang Wang , Xinyu Zhou , Tao Tan , Ki Ho Park , H Fritz Kramer , Alan McDougal , Nicholas J Laping , Sanjay Kumar , T M Ayodele Adesanya , Matthew Sermersheim , Frank Yi , Xinxin Wang , Junwei Wu , Kristyn Gumpper , Qiwei Jiang, Duofen He , Pei-Hui Lin , Haichang Li , Fangxia Guan , Jingsong Zhou , Mark J Kohr , Chunyu Zeng , Hua Zhu, Jianjie Ma (2019). Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function. Nat Commun. 10(1):4659. PMCID:PMC6789113. DOI: 10.1038/s41467-019-12483-0.
  • Cheng-long Jin, Jin-ling Ye, Jinzeng Yang, Chun-qi Gao, Hui-chao Yan, Haichang Li and Xiu-qi Wang (2019). mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth. Cells. 8(12): 1549; PMCID:PMC6953079. DOI: 10.3390/cells8121549.
  • Xin Zhou, Haichang Li, Xinyu Zhou, Tao Tan, Xuehong Xu, and Jianjie Ma (2019). Topical Application of Recombinant Human MG53 Protein Facilitates Healing of Chronic Wounds in Diabetic Mice. FASEB. Vol. 33, No. 1_supplement, Pages lb1-872.4 DOI: https://www.fasebj.org/toc/fasebj/33/1supplement.
  • Cheng-long Jin, Zong-ming Zhang, Jin-ling Ye, Chun-qi Gao, Hui-chao Yan, Haichang Li, Jin-zeng Yang and Xiu-qi Wang (2019). Lysine-induced swine satellite cell migration is mediated by the FAK pathway. Food Funct. 10(2):583-591. PMCID:30672919. DOI: 10.1039/C8FO02066C.
  • Zhaobo Fan, Zhaobin Xu, Hong Niu , Yang Sui, Haichang Li, Jianjie Ma , Jianjun Guan (2019). Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction. J. Control. Release. 311-312:233-244. PMCID:PMC6874903. DOI: 10.10(16/j.jconrel.2019.09.005.
  • Hong Niu, Xiaofei Li, Haichang Li, Zhaobo Fan, Jianjie Ma, Jianjun Guan (2019) Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery. Acta Biomaterialia. 83:96-108 PMCID:PMC6296825. DOI: 10.1016/j.actbio.2018.10.038.
  • Haichang Li (2018). PCL2 a novel tumor suppressor in breast cancer. Sci. Bull. DOI: 10.1016/j.scib.2018.04.004.
  • Zhaobo Fan, Zhaobin Xu, Hong Niu, Ning Gao, Ya Guan, Chao Li, Yu Dang, Xiaoyu Cui,Xuanyou Liu Liu, Yunyan Duan, Haichang Li, Xinyu Zhou, Pei-Hui Lin, Jianjie Ma, and Jianjun Guan(2018). An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction. Sci Rep. 8(1):1371. PMCID: PMC5778078. DOI: 10.1038/s41598-018-19906-w.
  • Cheng-Long Jin, Qiang Wang, Zong-Ming Zhang, Yin-Long Xu, Hui-Chao Yan, Haichang Li, Chun-Qi Gao, Xiu-Qi Wang (2018). Dietary supplementation with pioglitazone hydrochloride and chromium-methionine improves growth performance, meat quality and antioxidant ability in finishing pigs. J. Agric. Food Chem. 66(17):4345–4351. PMCID: PMC29682966. DOI: 10.1021/acs.jafc.8b01176.
  • Cheng-Long Jin, Chun-Qi Gao, Qiang Wang, Zong-Ming Zhang, Yin-Long Xu, Haichang Li, Hui-Chao Yan, Xiu-Qi Wang (2018). Effects of pioglitazone hydrochloride and Vitamin E on meat quality and antioxidant status and fatty acid profiles in finishing pigs. Meat Science. 145:340-346. PMCID:30015164. DOI: 10.1016/j.meatsci.2018.07.008.
  • Pei-Hui Lin, Matthew Sermersheim, Haichang Li, Peter H. U. Lee, Steven M. Steinberg and Jianjie Ma (2018). Zinc in Wound Healing Modulation. Nutrients. 10(1), 16; PMCID: PMC5793244. DOI: 10.3390/nu10010016.
  • Zhaobo Fan, Minghuan Fu, Zhaobin Xu, Bo Zhang, Zhihong Li, Haichang Li, Xinyu Zhou, Xuanyou Liu, Yunyan Duan, Pei-Hui Lin, Pu Duann, Xiaoyun Xie, Jianjie Ma, Zhenguo Liu, and Jianjun Guan (2017). Sustained Release of a Peptide-based Matrix Metalloproteinase-2 Inhibitor to Attenuate Adverse Cardiac Remodeling and Improve Cardiac Function Following Myocardial Infarction. Biomolecules. 18(9):2820-2829. PMCID: PMC5723129. DOI: 10.1021/acs.biomac.7b00760.
  • Mi Li, Haichang Li (Co-first author), Xiangguang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma, Mingjun Zhang (2017). A bio-inspired alginate-gum arabic hydrogels with hierarchical micro/nano-scale structures for controlled drug release in chronic wound healing. ACS Appl. Mater. Interfaces. 9 (27):22160–22175. PMCID: PMC5979260. DOI: 10.1021/acsami.7b04428.
  • Xinxin Wang, Junwei Wu, Xinyu Zhou, Pei-Hui Lin, Haichang Li, Hua Zhu, Tao Tan, Matthew Swrmersheim, Fangxia Guan and Jianjie Ma (2017). MG53 Negatively Regulates NLRP3 to Inhibit Inflammation Associated with Tissue Injury. Biophys. DOI: 10.1016/j.bpj.2016.11.2876.
  • Chunqi Gao, Yinlong Xu, Chenglong Jin, Xiaochao Hu, Haichang Li, Huichao Yan, and Xiu-Qi Wang (2017). Differentiation capacities of skeletal muscle satellite cells in Lantang and Landrace piglets. Oncotarget. 8(26): 43192–43200. PMCID:PMC5522138. DOI: 10.18632/oncotarget.17860.
  • Yonggang Yao, Bo Zhang, Hua Zhu, Haichang Li, Yu Han, Ken Chen, Zhen Wang, Jing Zeng, Yukai Liu, Xingquan Wang, Yu Li, Duofen He, Peihui Lin, Xinyu Zhou, Ki Ho Park, Zehua Bian, Zhishui Chen, Nianqiao Gong, Tao Tan, Jianjie Ma and Chunyu Zeng (2016). MG53 permeates through blood-brain barrier to protect ischemic brain injury. Oncotarget . 7(16): 22474–22485. PMCID:PMC5008374. DOI: 10.1016/j.jacc.2016.07.098.
  • Xiangguang Li, Weiguo Sui, Chunqi Gao, Huichao Yan, Yulong Yin, Haichang Li, and Xiuqi Wang (2016). L-Glutamate deficiency can trigger proliferation inhibition via down regulation. J. Anim. Sci. 94(4):1541–1549. PMCID:27136013. DOI: 10.2527/jas.2015-9432.
  • ChunQi Gao, HaoJie Zhang, HuiChao Yan, Li Yuan, Sudath Dahanayaka, Haichang Li (Corresponding author), and XiuQi Wang (2016). Satellite cells isolated from skeletal muscle will proliferate faster in WENS yellow feather chicks. J. Anim. Sci. 87(1) 126–133. PMCID: 26248947. DOI: 10.1111/asj.12403.
  • Dan Wang, Chunqi Gao, Chenglong Jin, Haichang Li, Huichao Yan, and Xiuqi Wang (2016). Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells. Oncotarget. (21): 30845–30854. PMCID: PMC5058722. DOI: 10.18632/oncotarget.9010.
  • Chunqi Gao, Yinling Zhao, Haichang Li, Weiguo Sui, Huichao Yan, Xiuqi Wang (2015). Heat stress inhibits proliferation, promotes growth and induces apoptosis in cultured lantang swine skeletal muscle satellite cells. J. Zhejiang Univ. SCI. B. 16(6):549-559. PMCID: PMC4471607. DOI: 10.1631/jzus.B1400339.
  • Chunqi Gao, Rui Zhi, Zhou Yang, Haichang Li, Huichao Yan, Xiuqi Wang (2015). Low dose of IGF-I increases cell size of skeletal muscle satellite cells via Akt/S6K signaling pathway. J. Cell. Biochem. 116(11):2637-48. PMCID:25923195. DOI: 10.1002/jcb.25212.
  • Pu Duann, Haichang Li (Co-first author), Peihui Lin, Tao Tan, Zhen Wang, Ken Chen, Xinyu Zhou, Kristyn Gumpper, Thomas Ludwig, Peter J. Mohler, Brad Rovin, William Abraham, Chunyu Zeng, and Jianjie Ma (2015). MG53-mediated cell membrane repair protects against acute kidney injury. Sci. Transl. Med. 7(279):279ra36. PMCID: PMC4524523. DOI:10.1126/scitranslmed.3010755.
  • Haichang Li (Co-corresponding author), Pu Duann, Pei-Hui Lin, Li Zhao, Zhaobo Fan, Matthew Orange, Matthew Sermersheim, Hanley Ma, Steven M. Steinberg, Robert Higgins, Hua Zhu, Elizabeth John, Jianjun Guan, and Jianjie Ma (2015). Modulation of wound healing and scar formation by MG53-mediated cell membrane repair. J. Biol. Chem. 290(40): 24592-03. PMCID: PMC4591837. DOI: 10.1074/jbc.M115.680074.
  • Mingzhai Sun, Jiaqing Huang, Kristyn Gumpper, Gejing De, Matthew Sermersheim, Pei-Hui Lin, Haichang Li, Pu Duann, Jianjie Ma (2014). Superresolution Microscopy Reveals Nanometer-Scale Reorganization of MG53 Associated with Membrane Repair. Biophys. 106(2):633a. DOI: 10.1016/j.bpj.2013.11.3503.
  • Zhenqing Li, Yanyi Xu, Haichang Li, Jianjun Guan (2014). Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions. Science China. 57(4): 568-578. DOI: 10.1007/s11426-014-5089-8.
  • Pei-Hui Lin, Pu Duann, Shinji Komazaki, Ki Ho Park, Haichang Li, Mingzhai Sun, Matthew Sermersheim, Kristyn Gumpper, John Parrington, Antony Galione, A. Mark Evans, Michael X. Zhu and Jianjie Ma (2014). Lysosomal two-pore channel subtype 2 regulates lysosome signaling during autophagy in skeletal muscle. J. Biol. Chem. 290, 3377-3389 (Featured in a JBC virtual issue on Autophagy, 2017). PMCID: PMC4319008. DOI: 10.1074/jbc.M114.608471.
  • Yanlin Jia, Ken Chen, Peihui Lin, Gissela Lieber, Miyuki Nishi, Rosalie Yan, Zhen Wang, Yonggang Yao, Yu Li, Bryan A. Whitson, Pu Duann, Haichang Li, Xinyu Zhou, Hua Zhu, Hiroshi Takeshima, John C. Hunter, Robbie L. McLeod, Noah Weisleder, Chunyu Zeng and Jianjie Ma (2014). Treatment of acute lung injury by targeting MG53-mediated cell membrane repair. Nat. Commun. 5: 4387. PMCID: PMC4109002. DOI: 10.1038/ncomms5387.
  • Haichang Li, Pu Duann, Zhaobo Fan, Li Zhao, Pei-Hui Lin, Mingzhai Sun, Gejing De, Xinyu Zhou, Jianjun Guan, Jianjie Ma (2014). The Therapeutic Role of Recombinant Human MG53 Protein in Wound Healing. Biophys. 106 (2): 53a. DOI: 10.1016/j.bpj.2013.11.594.
  • Gejing De, Jae-Kyun Ko, Tao Tan, Hua Zhu, Haichang Li, and Jianjie Ma (2014). Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment. Oncotarget. 5(17): 7734-47. PMCID: PMC4202157. DOI: 10.18632/oncotarget.2301.
  • Mattew Orange, Christopher Ferrante, Rosalie Yan, Tao Tan, Norio Takizawa, Pei-Hui Lin, Haichang Li, Hiroshi Takeshima, Noah Weisleder, Jianjie Ma (2013). MG53 can Function in Keratinocyte Membrane Repair and Contribute to Excisional Wound Healing in Rodent Skin. Biophys. DOI: 10.1016/j.bpj.2012.11.1638.
  • Gauri Kulkarni, Zhennan Xu, Ahmed Mohamed, Haichang Li, Xia Tang, Gerard Limerick and William G. Wadsworth (2013). Experimental Evidence for UNC-6 (netrin) Axon Guidance by Stochastic Fluctuations of Intracellular UNC-40 (DCC) outgrowth activity. Biology Open. 2:1300-1312. PMCID: PMC3863414. DOI: 10.1242/bio.20136346.
  • Zhennan Xu, Haichang Li, and William G. Wadsworth (2009). The Roles of Multiple UNC-40 (DCC) Receptor-mediated Signals in Determining Neuronal Asymmetry Induced by the UNC-6 (netrin) Ligand. Genetics. 183(3): 941-959. PMCID: PMC2778989. DOI: 10.1534/genetics.109.108654.
  • Gauri Kulkarni, Haichang Li (Co-first author), William G. Wadsworth (2009). CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40 mediated axon outgrowth and promotes presynaptic development in C.elegans. J. Neurosci. 29(17): 4541-4550. PMCID: PMC2644262. DOI: https://doi.org/10.1523/JNEUROSCI.5542-07.2008.
  • Haichang Li, Gauri Kulkarni, & William G. Wadsworth (2008). RPM-1, a C.elegans protein that functions in presynaptic differentiation, negatively regulates axon outgrowth by controlling SAX-3/robo and UNC-5/UNC5 activity. J. Neurosci. 28(14): 3596-3603. PMCID: PMC6671101. DOI: https://doi.org/10.1523/JNEUROSCI.5536-07.2008.
  • Masahiro Yamaguchi, Noriko Tonou-Fujimori, Atsuko Komori, Ryu Maeda, Yasuhiro Nojima, Haichang Li, Hitoshi Okamoto and Ichiro Masai (2005). Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. Development 132(13): 3027-43. PMCID: 15944187. DOI: 10.1242/dev.01881.
  • Haichang Li, Zhao Li, Hiroshi Kagami, Kanji Matsui and Tamao Ono (2001). Identification of transferred chicken germ cells in quail gonad and semen by amplification of chicken-specific PCR products. J. Poult. Sci. 38(4): 308-316. DOI: https://doi.org/10.2141/jpsa.38.308.
  • Haichang Li, Kanji Matsui and Tamao Ono (2001). Population of Circulating Primordial Germ Cells in Early Japanese Quail Embryos. J. Poult. Sci. 38(2):175-180. DOI: https://doi.org/10.2141/jpsa.38.175.
  • Haichang Li, Hiroshi Kagami, Kanji Matsui and Tamao Ono (2001). Restricted proliferation of primordial germ cells (PGCs) by the irradiation of soft X-ray in Japanese quail embryos, Comp. Biochem. Physiol. 130: 133-140. PMID:11672689. DOI:10.1016/s1095-6433(01)00375-0.
  • Zandong Li, Fujiro Sakura, Haichang Li, Jinsong Huang, Xiangzhi Li, Manfu Zhang and Sunzhang Qi (1997). The activities of blood alkaline phosphates (ALP) in chick embryos during culture in vitro, Acta Husbandry and Veterinary Sinica. 28(3):156-167.
  • Zandong Li, Fujiro Sakura, Xiang-Zhi Li, Jin-Song Huang, Haichang Li and Sun-Zhang Qi Deng (1996). Determination of bone Plasma alkaline phosphates (ALP) in chick embryos cultured in recipient egg-shells. Acta Husbandry and Veterinary Sinica. 27(4): 326-32.

Book

  • Dong-Hua Yang and Haichang Li (2022). New Modalities in Cancer Diagnostics and Therapeutics (E-book). ISBN 978-2-83251-045-2. DOI: 10.3389/978-2-83251-045-2.
  • Dong-Hua Yang, Pascale Cohen, Haichang Li, Yingyan Yu (2021). New Technologies in Cancer Diagnostics and Therapeutics (E-book). ISBN 978-2-88971-524-4. DOI:10:3389/978-2-88971-524-4.