Gaofeng Xiong
Assistant Professor
Contact
xiong.587@osu.edu 614-292-4169 Veterinary Medicine Academic Building1900 Coffey Rd.
Columbus, Ohio 43210
Map Link
Department
Veterinary Biosciences
Professional Training and experience
- Assistant Professor, Department of Veterinary Biosciences, The Ohio State University
- Research Assistant Professor, Markey Cancer Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Research Scientist, Markey Cancer Center, University of Kentucky
- Postdoc, Markey Cancer Center, University of Kentucky
- PhD, Developmental Biology, Institute of Zoology, Chinese Academy of Sciences
- BA, Biology, Nanchang University
Research Interests
- Molecular mechanism leading to therapy resistance, recurrence and metastasis in breast cancer
- New biomarkers and therapeutic targets for breast cancer treatment
- Translational study to improve current breast cancer therapeutic strategies
- Develop novel in vitro and in vivo models for testing novel anti-cancer drugs or drug delivery
Memberships
American Association for Cancer Research
Professional Services
2023 Ad hoc Reviewer for NIH study section: ATA
Journal Peer-Reviewing
Integrative Biology, Journal of Nanomaterials, International Journal of Biological Sciences, Journal of Biochemistry and Physiology, Frontiers in Cell and Developmental Biology, International Journal of Cancer, Molecular and Cellular Biochemistry, Frontiers in Veterinary Science, Reproductive Biology and Endocrinology, Development, Frontiers in Oncology, Growth and Differentiation Life Sciences, Genes & Genomics
Selected Honors & Awards
- 2023 NIH Exploratory/Developmental Research Grant Award (R21)
- 2019 American Cancer Society, Institutional Research Grant Award
- 2016 Oral Presentation on Markey Cancer Center Research Day Symposium
- 2015 Highlighting work on the front cover story of Integrative Biology Journal
- 2010 Award of Academic Excellent graduate in Chinese Academy of Science
- 2005 Award of Wang’s Foundation fellowship at Nanchang University
- 2004 Prize for Outstanding Students at Social Work at Nanchang University
- 2004 Wang Xuedong’s scholarship at Nanchang University
- 2003 First Prize in China Undergraduate Mathematical Contest in Modeling
Publications
Publications
- Xiong G, He D, Napier D, Hurley P, Wang C, Zhou C, Nagata K, Theresa JP, Xu R. Hsp47 drives obesity-associated cancer progression by enhancing asporin deposition in adipose tissue (Under Reviewing).
- Xiong G* (Corresponding Author), Xu R. Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial-mesenchymal transition (EMT) by directly repressing Snail transcription. J Biol Chem. 2022 May
- Xiong G, Chen J, Zhang G, Wang S, Kawasaki K, Zhu J, Zhang Y, Nagata K, Li Z, Zhou BP, Xu R. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.Proc Natl Acad Sci U S A. 2020 Feb
- Xiong G, Stewart R, Chen J, Gao T, Scott TL, Samayoa L M, O’Connor K, Lane AN, Xu R. Collagen proly- hydroxylase is essential for HIF-1α stabilization and TNBC chemoresistance. Nature Communications. 2018 Oct
- Xiong G, Xu R. Function of cancer cell-derived extracellular matrix in tumor progression. J Cancer Metasta Treat. 2016 Sep
- Xiong G, Flynn T, Chen J, Trinkle CA, Xu R. Development of an ex vivo breast cancer lung colonization model utilizing decellularized lung matrix. Integrative Biology. 2015 Dec
- Zhu J, Xiong G* (Co-first author), Hanjiang Fu, Mark Evers B., Binhua P. Zhou, Ren Xu. Chaperone Hsp47 drives malignant growth and invasion by modulating an ECM gene network. Cancer research 2015 Apr.
- Xiong G, Xu R. ROR alpha Suppresses Cells Proliferation and cell cycle progression by binding to E2F1 and reducing its acetylation. Mol Cell Biol. 2014 Aug
- Xiong G, Deng L, Zhu J, Rychahou PG, Xu Ren. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan
- Xiong G, Wang C, Evers BM, Zhou BP, Xu R. RORα suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Research. 2012 Apr
- Xiong GF, Zhang YS, Han BC, Chen W, Yang Y, Peng JP. Estradiol-regulated proline-rich acid protein 1 is repressed by class I histone deacetylase and functions in peri-implantation mouseuterus.Mol Cell Endocrinol. 2011 Jan
- Tong Y, Qi Y, Xiong G, Li J, Scott T, Chen J, He D, Li L, Wang C, Lane AN, Xu R. The PLOD2/Succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness. Proc Natl Acad Sci U S A. 2023.
- Mao W, Xiong G, Wu Y, Wang C, St Clair D, Li JD, Xu R. RORα Suppresses Cancer- Associated Inflammation by Repressing Respiratory Complex I-Dependent ROS Generation. Int J Mol Sci. 2021 Oct
- Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA for Triple- Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133. Mol Ther. 2019 Jul
- Zhang H, Fredericks T, Xiong G, Qi Y, Li J, Pihlajaniemi T, Xu W, and Xu R, Membrane- associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Breast Cancer Research. 2018 Oct
- Li L, Chen J, Xiong G, St Clair DK, Xu W, Xu R. Increased ROS production in non- polarized mammary epithelial cells induces monocyte infiltration in 3D culture. J Cell Sci. 2017 Jan
- Shu D, Li H, Shu Y, Xiong G, Xu R, Carson WE 3rd, Haque F, Guo P. Systemic Delivery of Anti- miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology. ACS Nano. 2015 Oct.
- Zhu JQ, Xiong G, Trinkle C, Xu R. Integrated extracellular matrix signaling in mammary gland development and breast cancer progression. Histol Histopathol. 2014 Mar
- Becker-Weimann S,Xiong G,Furuta S,Han J,Kuhn I,Akavia UD,Pe'er D, BissellMJ, Xu R. NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget. 2013 Oct
- Yu MF, Fang WN, Xiong GF, Yang Y, Peng JP. Evidence for the inhibition of fertilization in vitro by anti- ZP3 antisera derived from DNA vaccine. Vaccine. 2011 Jul
- Chen W, Han BC, Wang RC, Xiong GF, Peng JP. Role of secretory protease inhibitor SPINK3 in mouse uterus during early pregnancy.Cell Tissue Res. 2010 Sep
- Zhang YS, Xiong, Peng JP. Effects of TGF beta-1 on mouse embryo implantation and expression of H2-D1 and H2-DM. Front Biosci. 2010 Jan