People

Gaofeng Xiong

PhD

Assistant Professor

Contact

xiong.587@osu.edu 614-292-4169 Veterinary Medicine Academic Building
1900 Coffey Rd.
Columbus, Ohio 43210
Map Link

Department

Veterinary Biosciences

Professional Training and Experience

  • Assistant Professor, Department of Veterinary Biosciences, The Ohio State University
  • Research Assistant Professor, Markey Cancer Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky
  • Research Scientist, Markey Cancer Center, University of Kentucky
  • Postdoc, Markey Cancer Center, University of Kentucky
  • PhD, Developmental Biology, Institute of Zoology, Chinese Academy of Sciences
  • BA, Biology, Nanchang University

Research Interests

  • Molecular mechanism leading to therapy resistance, recurrence and metastasis in breast cancer
  • New biomarkers and therapeutic targets for breast cancer treatment
  • Translational study to improve current breast cancer therapeutic strategies
  • Develop novel in vitro and in vivo models for testing novel anti-cancer drugs or drug delivery

 

Memberships

  • American Association for Cancer Research
  • Society of Chinese Bioscientists in America
  • Cancer Biology Program, The OSU Comprehensive Cancer Center
  • Comparative and Translational Oncology Signature Program, OSU

Professional Services

  • 2023 Ad hoc Reviewer for NIH study section: ATA
  • 2025 Review for AHA Basic Science
  • 2025 Reviewer for Congressionally Directed Medical Research Program, DoD BCRP

Journal Peer-Reviewing

  • Integrative Biology, Journal of Nanomaterials, International Journal of Biological Sciences, Journal of Biochemistry and Physiology, Frontiers in Cell and Developmental Biology, International Journal of Cancer, Molecular and Cellular Biochemistry, Frontiers in Veterinary Science, Reproductive Biology and Endocrinology, Development, Frontiers in Oncology, Growth and Differentiation Life Sciences, Genes & Genomics

     

Selected Honors & Awards

  • 2023 NIH Exploratory/Developmental Research Grant Award (R21)
  • 2019 American Cancer Society, Institutional Research Grant Award
  • 2016 Oral Presentation on Markey Cancer Center Research Day Symposium
  • 2015 Highlighting work on the front cover story of Integrative Biology Journal
  • 2010 Award of Academic Excellent graduate in Chinese Academy of Science
  • 2005 Award of Wang’s Foundation fellowship at Nanchang University
  • 2004 Prize for Outstanding Students at Social Work at Nanchang University
  • 2004 Wang Xuedong’s scholarship at Nanchang University
  • 2003 First Prize in China Undergraduate Mathematical Contest in Modeling

Publications

Publications

A complete list of published works is in My Bibliography-NCBI and Gao-feng Xiong-Google Scholar.

Selected Publications

  • Kang B, Xu R, Xiong G*. Adipocyte Hsp47: A Novel Regulator of Obesity and Obesity-Associated Breast Cancer. J Cancer Treatment Diagn. 2025 Oct 27;8(3):1-5.
  • Hironaka D., Xiong G*. Enhanced Collagen Prolyl 4-Hydroxylase Activity and Expression Promote Cancer Progression via both Canonical and Non-Canonical Mechanisms. Int J Mol Sci. 2025 Sep 25;26(19): 9371.
  • Xiong G, He D, Napier D, Chen J, Shi H, Li C, Hurley P, Wang C, Zhu H, Zhou C, Theresa JP, Xu R. Hsp47 drives obesity-associated cancer progression by enhancing asporin deposition in adipose tissue. Breast Cancer Res. 2025 Jul 6;27(1):125.
  • Xiong G*, Obringer B, Jones A, Horton EM, Xu R. Regulation of RORα stability through PRMT5-Dependent Symmetric Kimethylation. Cancers. 2024 May 17;16(10):1914.
  • Bhullar AS, Jin K, Shi H, Jones A, Hironaka D, Xiong G, Xu R, Guo P, Binzel DW, Shu D. Engineered Extracellular Vesicles for Combinatorial TNBC Therapy: SR-SIM-Guided Design Achieves Substantial Drug Dosage Reduction. Mol Ther. 2024 Dec 4;32(12):4467-4481.
  • Tong Y, Qi Y, Xiong G, Li J, Scott T, Chen J, He D, Li L, Wang C, Lane AN, Xu R. The PLOD2/Succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness. Proc Natl Acad Sci USA. 2023 may 16;120(20):e2214942120.
  • Xiong G*, Xu R. Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial-mesenchymal transition (EMT) by directly repressing Snail transcription. J Biol Chem. 2022 Jul;298(7):102059.
  • Xiong G, Chen J, Zhang G, Wang S, Kawasaki K, Zhu J, Zhang Y, Nagata K, Li Z, Zhou BP, Hu R. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proc Natl Acad Sci USA, 292 Feb 18:117(7):3748-3758.
  • Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133. Mol Ther. 2019 Jul 3;27(7):1252-1261.
  • Xiong G, Stewart R, Chen J, Gao T, Scott TL, Samayoa LM, O'Connor K, Lane AN, Xu R. Collagen prolyl-hydroxylase is essential for HIF-1α stabilization and TNBC chemoresistance. Nature Communications. 2018 Oct 26;9(1):4456.
  • Xiong G, Flynn T, Chen J, Trinkle CA, Xu R. Development of an ex vivo breast cancer lung colonization model utilizing decellularized lung matrix. Integrative Biology. 2015 Dec;7(12):1518-25.
  • Shu D, Li H, Shu Y, Xiong G, Xu R, Carson WE 3rd, Haque F, Guo P. Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology. ACS Nano. 2015 Oct 27;9(10):9731-40.
  • Zhu J, Xiong G*, Hanjiang Fu, Mark Evers B, Binhua P, Zhou, Ren Xu. Chaperone Hsp47 drives malignant growth and invasion by modulating an ECM gene network. Cancer Research. 2015 Apr 15;75(8):1580-91.
  • Xiong G, Xu R. ROR alpha Suppresses Cells Proliferation and cell cycle progression by binding to E2F1 and reducing its acetylation. Mol Cell Biol. 2014 Aug;34(16):3066-75.
  • Xiong G, Deng L, Zhu J, Rychahou PG, Xu Ren. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2:14:1.
  • Xiong G, Wang C, Evers BM, Zhou BP, Xu R. RORα suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Research. 2012 Apr 1;72(7):1728-39.