Current Trials

Your pet can participate in one of our current clinical trials and become a Pet Hero!

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For a complete list of our current clinical trials click here.

Cat

Heart (Cardiology)

The goal of this study is to prove that Pimobendan improves atrial function and thus prevents stagnating blood flow, possibly preventing the development of thromboembolic disease, a common and often deadly consequence of hypertrophic cardiomyopathy.
This study addresses the hypothesis that echocardiography can identify congestive heart failure (CHF) in cats non-invasively by predicting elevated filling pressure, respiratory rate and radiographic findings diagnostic for CHF.    

Emergency and Critical Care

Early use of a drug to break up or dissolve blood clots (Tissue Plasminogen Activator) for blood clots in cats. -- The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).

Internal Medicine

The purpose of this study is to demonstrate how the drug is processed in the body of CKD cats in comparison to normal cats so that these patients can benefit from its use without over sedation.
The primary goal for this study is to evaluate if omeprazole is effective in alleviating GI signs in cats with CKD.
This study aims to determine blood aluminum levels in cats with chronic kidney disease. This study will also aim to determine blood aluminum levels in cats with chronic kidney disease to see if diet influences blood aluminum levels.
The purpose of this study is to determine whether there is a significant difference in Aluminum levels between healthy cats and those with various stages of chronic kidney disease (CKD).
The purpose of this study is to evaluate the efficacy of a new diet specially formulated to dissolve struvite stones in the bladders of cats.      
Dog

Anesthesia and pain management

The objective is to evaluate PI as a non-invasive method to determine epidural anesthesia onset and effectiveness in dogs.

Internal Medicine

Dogs are commonly affected by sudden onset diarrhea.  This can be a distressing problem for our dogs and a frustrating management concern for us as pet parents.  This study aims to investigate the effectiveness and impact of current treatment protocols to determine the best approach in these patients. 
The primary objective of this study is to characterize the natural disease progression of chronic kidney disease (CKD) in dogs presented as veterinary patients by monitoring their health status, as well as blood and urine values at regular intervals during visits at the Ohio State University.
Protein in the urine (proteinuria) is common in dogs and causes further damage to the kidneys. This study aims to determine whether the standard drugs used to treat proteinuria can completely suppress one of the hormones involved in kidney regulation, and whether lack of complete suppression affects the amount of proteinuria.
This study aims to look further into pain management associated with urologic endoscopy (cystoscopy), a common diagnostic tool in use for the evaluation of lower urinary tract disorders in dogs.

Pathology

The purpose of this project is to characterize the most common type(s) of kidney disease in American Boxer dogs in order to identify a possible genetic cause of the disease.
The purpose of this project is to characterize the most common type(s) of kidney disease in Dalmatian dogs in order to identify a possible genetic cause of the disease.

Brain and nervous system (Neurology and Neurosurgery)

Syringomyelia (SM) is a painful neurological problem which causes neuropathic pain (NP) behaviors such as scratching, face rubbing, and intermittent vocalizations in affected dogs. Pain management of SM-NP is currently limited by the lack of objective ways to assess severity of pain in dogs with the condition. The long-term goal of our group is to improve the diagnosis and management of neuropathic pain in dogs.
Evaluation of sensory dysfunction in Cavalier King Charles Spaniels with Chiari malformation/syringomyelia. -- The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.

Cancer (Oncology)

The purpose of the trial is to identify non-invasive biomarkers that may help us predict patients at increased risk for chemotherapy induced gastrointestinal mucositis, and offer them more aggressive prophylactic treatment and supportive care to limit the impact on quality of life and treatment outcome.
This project will provide a foundation for the understanding of cellular senescence across species as well as identify possible therapeutic targets for reducing side effects and improving outcome in dogs and humans with cancer undergoing chemotherapy
In this study, we aim to use a new approach to stimulate the body’s own immune system to attack remaining tumor cells in dogs that have undergone standard of care limb amputation and chemotherapy for the treatment of bone tumors (Osteosarcoma).
The purpose of this study if to evaluate differences between clinical investigators in lymph node measurement obtained via calipers compared with ultrasound. 
To evaluate the biologic activity associated with oral administration of PLX4720 to dogs bladder cancer and with BRAF mutation, and to assess adverse events associated with chronic PLX4720 dosing.
The purposes of the study are to assess feasibility and safety of the microwave ablation therapy for the treatment of distal radial osteosarcomas in dogs, to measure the volume of treated tissue and to record the presence of collateral damages (soft tissue).
The purposes of the study are to assess clinical efficacy, to record the associated complications (intra and post-operative complications) and the potential effects on long term survival of the microwave ablation therapy for the treatment of liver/pulmonary/renal metastatic diseases.
The primary objective of this study is to evaluate the activity of an investigational drug given to dogs with cancer that have not yet been treated or have failed chemotherapy. 
The proposed study will identify the efficacy of corticosteroids steroids in reducing microscopic mast cell tumor (MCT) tumor burden.  We seek new, evidence-based guidelines for the treatment of MCT, such as smaller surgical margin size, which could reduce the complications associated with surgery.

Radiology

This clinical trial evaluates the safety and efficacy of low dose radiation therapy (LD-RT) for dogs with elbow arthritis. Osteoarthritis (OA) of the elbows is progressive and debilitating disease both in people and dogs. The doses of radiation therapy used to treat arthritis are much lower than those used to treat cancerous tumors, thus the designation “low dose radiation therapy.

Bones and joints (Orthopedic Surgery)

This investigation will evaluate the efficacy of three common neuroanalgesic procedures on short term perioperative pain management and evaluate chronic sensory threshold as a measure of neuropathic pain in the dog.