The goal of this study is to prove that Pimobendan improves left atrial function and thus prevents stagnating blood flow, possibly preventing the development of thromboembolic disease, a common and often deadly consequence of hypertrophic cardiomyopathy.
Early use of a drug to break up or dissolve blood clots (Tissue Plasminogen Activator) for blood clots in cats. -- The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).
This study aims to determine blood aluminum levels in cats with chronic kidney disease. This study will also aim to determine blood aluminum levels in cats with chronic kidney disease to see if diet influences blood aluminum levels.
The causes of the different response patterns of the lungs to left heart disease are unknown. Therefore, the investigators hypothesized that different pulmonary vascular response patterns may be identified more specifically by lung computed tomography (CT).
Dogs are commonly affected by sudden onset diarrhea. This can be a distressing problem for our dogs and a frustrating management concern for us as pet parents. This study aims to investigate the effectiveness and impact of current treatment protocols to determine the best approach in these patients.
The primary objective of this study is to characterize the natural disease progression of chronic kidney disease (CKD) in dogs presented as veterinary patients by monitoring their health status, as well as blood and urine values at regular intervals during visits at the Ohio State University.
Protein in the urine (proteinuria) is common in dogs and causes further damage to the kidneys. This study aims to determine whether the standard drugs used to treat proteinuria can completely suppress one of the hormones involved in kidney regulation, and whether lack of complete suppression affects the amount of proteinuria.
Syringomyelia (SM) is a painful neurological problem which causes neuropathic pain (NP) behaviors such as scratching, face rubbing, and intermittent vocalizations in affected dogs. Pain management of SM-NP is currently limited by the lack of objective ways to assess severity of pain in dogs with the condition. The long-term goal of our group is to improve the diagnosis and management of neuropathic pain in dogs.
Evaluation of sensory dysfunction in Cavalier King Charles Spaniels with Chiari malformation/syringomyelia. -- The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
The purpose of this clinical trial is to evaluate the safety and efficacy of PAC-1 (a novel anti-cancer drug) combined with doxorubicin for dogs with osteosarcoma that has spread to their lungs. PAC-1 is a new drug that can sensitize tumor cells to chemotherapy treatments such as doxorubicin.
The purpose of the trial is to identify non-invasive biomarkers that may help us predict patients at increased risk for chemotherapy induced gastrointestinal mucositis, and offer them more aggressive prophylactic treatment and supportive care to limit the impact on quality of life and treatment outcome.
This project will provide a foundation for the understanding of cellular senescence across species as well as identify possible therapeutic targets for reducing side effects and improving outcome in dogs and humans with cancer undergoing chemotherapy
In this study, we aim to use a new approach to stimulate the body’s own immune system to attack remaining tumor cells in dogs that have undergone standard of care limb amputation and chemotherapy for the treatment of bone tumors (Osteosarcoma).
The purposes of the study are to assess clinical efficacy, to record the associated complications (intra and post-operative complications) and the potential effects on long term survival of the microwave ablation therapy for the treatment of liver/pulmonary/renal metastatic diseases.
The proposed study will identify the efficacy of corticosteroids steroids in reducing microscopic mast cell tumor (MCT) tumor burden. We seek new, evidence-based guidelines for the treatment of MCT, such as smaller surgical margin size, which could reduce the complications associated with surgery.
This investigation will evaluate the efficacy of three common neuroanalgesic procedures on short term perioperative pain management and evaluate chronic sensory threshold as a measure of neuropathic pain in the dog.