The goal of this study is to prove that Pimobendan improves atrial function and thus prevents stagnating blood flow, possibly preventing the development of thromboembolic disease, a common and often deadly consequence of hypertrophic cardiomyopathy.
This study addresses the hypothesis that echocardiography can identify congestive heart failure (CHF) in cats non-invasively by predicting elevated filling pressure, respiratory rate and radiographic findings diagnostic for CHF.
Early use of a drug to break up or dissolve blood clots (Tissue Plasminogen Activator) for blood clots in cats. -- The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).
The objective of this study is to determine whether the earliest stage of kidney disease is associated with increased blood and urinary levels of a marker of oxidative stress, called isoprostanes. An additional goal is to explore the effect of diet on this marker. These results will help us determine whether cats with very early kidney disease should receive specific treatments.
This study aims to determine blood aluminum levels in cats with chronic kidney disease. This study will also aim to determine blood aluminum levels in cats with chronic kidney disease to see if diet influences blood aluminum levels.
Brainstem auditory evoked response (BAER) testing in normal hearing cavalier king charles spaniel dogs. -- Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss. This is a 1-day study. Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.
The purpose of this study is to evaluate the safety and mechanism of action of an investigational veterinary product (IVP) that is believed to be important in the disease process of canine chronic kidney disease (CKD) and its sequelae, mineral and bone disorder (MBD).
The primary objective of this study is to characterize the natural disease progression of chronic kidney disease (CKD) in dogs presented as veterinary patients by monitoring their health status, as well as blood and urine values at regular intervals during visits at the Ohio State University.
Protein in the urine (proteinuria) is common in dogs and causes further damage to the kidneys. This study aims to determine whether the standard drugs used to treat proteinuria can completely suppress one of the hormones involved in kidney regulation, and whether lack of complete suppression affects the amount of proteinuria.
Syringomyelia (SM) is a painful neurological problem which causes neuropathic pain (NP) behaviors such as scratching, face rubbing, and intermittent vocalizations in affected dogs. Pain management of SM-NP is currently limited by the lack of objective ways to assess severity of pain in dogs with the condition. The long-term goal of our group is to improve the diagnosis and management of neuropathic pain in dogs.
Evaluation of sensory dysfunction in Cavalier King Charles Spaniels with Chiari malformation/syringomyelia. -- The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
This project will provide a foundation for the understanding of cellular senescence across species as well as identify possible therapeutic targets for reducing side effects and improving outcome in dogs and humans with cancer undergoing chemotherapy
In this study, we aim to use a new approach to stimulate the body’s own immune system to attack remaining tumor cells in dogs that have undergone standard of care limb amputation and chemotherapy for the treatment of bone tumors (Osteosarcoma).
The purposes of the study are to assess feasibility and safety of the microwave ablation therapy for the treatment of distal radial osteosarcomas in dogs, to measure the volume of treated tissue and to record the presence of collateral damages (soft tissue).
The purposes of the study are to assess clinical efficacy, to record the associated complications (intra and post-operative complications) and the potential effects on long term survival of the microwave ablation therapy for the treatment of liver/pulmonary/renal metastatic diseases.
The proposed study will identify the efficacy of corticosteroids steroids in reducing microscopic mast cell tumor (MCT) tumor burden. We seek new, evidence-based guidelines for the treatment of MCT, such as smaller surgical margin size, which could reduce the complications associated with surgery.
The objective of this study is to evaluate the relative effectiveness of an investigational drug (D929) when applied topically to the eye at various dose levels under field conditions in dogs with dry eye.
This investigation will evaluate the efficacy of three common neuroanalgesic procedures on short term perioperative pain management and evaluate chronic sensory threshold as a measure of neuropathic pain in the dog.
The aim of this study is to evaluate a novel computed tomography (CT)-based quantitative index of airflow resistance in brachycephalic dogs before and after surgical intervention including the ablation of nasal turbinates.
Evaluation of a parathyroid hormone test in dogs undergoing parathyroid gland removal. -- The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.