The objective of this study is to determine whether the earliest stage of kidney disease is associated with increased blood and urinary levels of a marker of oxidative stress, called isoprostanes. An additional goal is to explore the effect of diet on this marker. These results will help us determine whether cats with very early kidney disease should receive specific treatments.
The proposed study will identify the efficacy of corticosteroids steroids in reducing microscopic mast cell tumor (MCT) tumor burden. We seek new, evidence-based guidelines for the treatment of MCT, such as smaller surgical margin size, which could reduce the complications associated with surgery.
This project will provide a foundation for the understanding of cellular senescence across species as well as identify possible therapeutic targets for reducing side effects and improving outcome in dogs and humans with cancer undergoing chemotherapy