Aldosterone in dogs with kidney disease

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Purpose and Brief Explanation of Study:

Protein in the urine (proteinuria) is common in dogs and causes further damage to the kidneys. This study aims to determine whether the standard drugs used to treat proteinuria can completely suppress one of the hormones involved in kidney regulation, and whether lack of complete suppression affects the amount of proteinuria.

If this study finds that standard drugs (i.e., ACE inhibitors like enalapril or benazepril or angiotensin-receptor blockers (ARB) like telmisartan) do not completely suppress aldosterone production, it opens an avenue for further research into additional drugs that could be used. 

What qualifies my dog for enrollment in this in this trial?

To participate in this clinical trial your dog must have:

  • Proteinuria from primary kidney disease
  • A urine protein:creatinine ratio of > 1 on two occasions

What does enrolling my dog in this clinical trial involve?

At the initial visit, each dog will have a physical examination, blood pressure measurement, blood tests (chemistry panel and CBC), and urine tests (urinalysis, urine protein:creatinine ratio, urine culture, and urine aldosterone test).  Treatment for proteinuria with an ACE inhibitor or ARB will start within one week of that visit, if the dog was not already receiving one of those drugs.


Follow-up visits will be needed at 1, 2, 4, and 6 months after enrollment.  At each visit, each dog will have a physical examination, blood pressure measurement, blood and urine tests (chemistry panel, CBC, urinalysis, urine protein:creatinine ratio, urine aldosterone).  For each of these visits, you will need to bring two urine samples from your dog, and an additional urine sample will be obtained while during the visit, either by voiding naturally or by cystocentesis (standard method of urine collection that involves inserting a needle into the bladder to obtain a sample).

Client Compensation

Following entry into the study, the owner will receive $75 off their pet’s bill for the first visit, and $150 off the bill for visits at months 1, 2, 4, and 6. The owner will be responsible for the costs of the initial diagnostic tests, and for the recheck exam, chemistry panel, urine protein:creatinine ratio, and blood pressure measurement at Month 1, 2, 4, and 6. 

Client Contact

If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire. 

Dr. Cathy Langston