Veterinary clinical trials are a unique opportunity to contribute to progress in medicine.

Knowledge from clinical trials not only improve the lives of your pet and other pets, but also impact countless humans.

The following is a list of publications of clinical trials made possible thanks to our Pet Heroes.

  1. Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs (2010)

  2. Biological activity of gemcitabine against canine osteosarcoma cell lines in vitro (2010)

  3. Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical mitral valve disease (2011)

  4. Adjuvant Carboplatin and Gemcitabine Combination Chemotherapy Postamputation in Canine Appendicular Osteosarcoma (2011)
  5. Hydrophilic Agarose Macrobead Cultures Select for Outgrowth of Carcinoma Cell Populations That Can Restrict Tumor Growth (2011)

  6. Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer (2011)
  7. Copy number variation in the domestic dog (2012)

  8. Multicenter prospective trial of hypofractionated radiation treatment, toceranib, and prednisone for measurable canine mast cell tumors (2012)
  9. Safety evaluation of combination vinblastine and toceranib phosphate (Palladia(R)) in dogs: a phase I dose-finding study (2012)

  10. A randomized trial investigating the efficacy and safety of water soluble micellar paclitaxel (Paccal Vet) for treatment of nonresectable grade 2 or 3 mast cell tumors in dogs (2012)
  11. Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs (2012)

  12. The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs (2013)
  13. Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose (2013)

  14. Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors (2014)
  15. Phase II Evaluation of VDC-1101 in Canine Cutaneous T-Cell Lymphoma (2014)

  16. Life-long diseases need life-long treatment: long-term safety of ciclosporin in canine atopic dermatitis (2014)
  17. Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study (2014)

  18. Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study (2015)
  19. The effects of preoperative oral administration of carprofen or tramadol on postoperative analgesia in dogs undergoing cutaneous tumor removal (2015)

  20. Maintenance therapy with toceranib following doxorubicin-based chemotherapy for canine splenic hemangiosarcoma (2015)
  21. Dogs as a Model for Cancer (2016)

  22. A pilot study of toceranib/vinblastine therapy for canine transitional cell carcinoma (2016)