Purpose and Brief Explanation of Study:
Chronic kidney disease (CKD) is a common and progressive condition in cats that can eventually result in a decreased appetite. This loss of appetite is a significant contribution to illness in these patients and can become a concern related to quality of life. In humans with CKD decreased appetite can occur due to dysregulation and imbalance in the hormones that control appetite. The purpose of our study is to investigate whether cats with CKD have altered concentrations and ratios of the hormones that control appetite. The long-term goal is to acquire information that can be used to help tailor treatment strategies for cats with CKD.
What qualifies my pet for enrollment in this in this trial?
Two groups of cats will be enrolled:
- Cats between 3-15 years old, with no known other illness and normal laboratory test results
- Obese (BCS 8 or 9/9) or underweight (BCS ≤ 3/9) cats will be excluded from enrollment in the healthy group.
Cats with kidney disease (CKD)
- Cats with CKD (serum creatinine ≥ 1.6 mg/dL or higher)
- Not other illness like gastrointestinal signs, diabetes, hyperthyroidism, or any other uncontrolled illness or significant complications related to their CKD
- Cats cannot have received an appetite stimulant in the last week prior to participation in the study.
What does enrolling my pet in this clinical trial involve?
Both normal and CKD cats will receive a physical examination, a blood pressure measurement, and a one-time blood and urine collection for a complete blood count, biochemical profile, thyroid level, and urinalysis. At the same time a small blood sample will be collected for the hormone measurements. We ask that you NOT FEED your cat in the 12 hours prior to sample collection for hormone measurements. Please bring a snack so that we can feed your cat after sample collection if they are not going home right away. If your cat ate on the day the routine diagnostics were done, we can schedule sample collection for the hormone measurements on another day. Additionally, you will be asked to fill out a questionnaire about your cat's appetite at home.
Your cat will receive complimentary physical exam, blood pressure and lab work (complete blood count, biochemical profile, thyroid level, and urinalysis).
Dr. Jessica Quimby