Lymph node measurements in dogs with lymphoma


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Purpose and Brief Explanation of Study:

The purpose of this study if to evaluate differences between clinical investigators in lymph node measurement obtained via calipers compared with ultrasound. Lymphoma is a very common type of cancer seen in dogs that develops from cancerous lymphocytes (white blood cells). Clinically, we most commonly see patients present with multicentric lymphoma, or enlargement of numerous peripheral lymph nodes.
These patients are treated with systemic chemotherapy administration. Patients’ response to therapy is often monitored by improvement or resolution of their enlarged lymph nodes. During treatment with chemotherapy, clinicians serially measure and monitor peripheral lymph nodes to monitor their patients’ response to chemotherapy. Currently, the standard or care is to measure peripheral lymph nodes with calipers. This makes the accurate measurement of lymph nodes critical for appropriate management of these patients. 

What qualifies my dog for enrollment in this in this trial?

To participate in this clinical trial your dog must have:
  • A cytologic or histopathologic diagnosis of lymphoma

What does enrolling my dog in this clinical trial involve? 

Your pet will have his/her peripheral lymph nodes measured with calipers by three individuals at presentation and then again at least 2 hours later. These individuals will include a board certified veterinary oncologist (Dr. Emma Warry), the medical oncology intern (Dr. Matt Cook) and a registered veterinary technician (Nicole Pastorek). The lymph nodes will also be measured using ultrasound by the same three individuals and a board certified veterinary radiologist (Dr. Eric Hostnik). These procedures will be repeated at your pet’s first re-check examination (day 7).

Measurement of peripheral lymph nodes with calipers is a non-invasive procedure that will cause no pain or discomfort to your pet. Measurement with ultrasound is also non-invasive and is performed without pain or discomfort. To accurately perform the ultrasound we may need to clip a small area of fur directly over the lymph node. Ultrasound gel will be placed onto your pet’s skin prior to the ultrasound. This will be cleaned off after the procedure has been performed, 
To obtain accurate measurements of the peripheral lymph nodes with calipers and ultrasound gentle restraint will be performed by an experienced clinician, technician or veterinary assistance. 
No special or additional visits will be required to the OSU-VMC. These measurements will be performed during your pet’s scheduled chemotherapy visits.
There are no costs associated with participation in this study. The study investigators will pay for the use of the focal ultrasound.  

Client Contact

If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire. 
Dr. Emma Warry