Gabapentin Sedation in Cats with and without Chronic Kidney Disease

 

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Purpose and Brief Explanation of Study:

Recently a medication called gabapentin has been successfully used to reduce stress in cats during veterinary visits. The recommended sedation dose of gabapentin may be beneficial to decrease stress in younger cats, but this dose may be inappropriate for cats with chronic kidney disease (CKD). Gabapentin is a medication that is cleared from the body by the kidneys and an increase in the amount of time it takes gabapentin to leave the body has been demonstrated in humans with moderate kidney disease. In cats, some vets have experienced that higher gabapentin doses lead to sedation in feline CKD patients.

Objective of the trial:

  • The purpose of this study is to demonstrate how the drug is processed in the body of CKD cats in comparison to normal cats so that these patients can benefit from its use without over sedation.

What qualifies my cat for enrollment in this in this trial?

Two groups of cats will be enrolled - normal cats and cats with CKD. Cats cannot already be getting Gabapentin at the time of the study

Normal Cats: Client-owned healthy cats with normal CBC, chemistry, urinalysis, SDMA, serum total T4 and blood pressure will be used. Healthy cats are defined as those with no clinical abnormalities, normal minimum database including a creatinine < 1.6 mg/dL and a urine specific gravity greater than 1.035 and an SDMA < 14.

CKD Cats: Cats with stable IRIS Stage 2, 3 or 4 chronic kidney disease (creatinine 2.0-8 mg/dL) are potentially eligible for entry into the study.  Diagnostic tests required before enrollment include a serum biochemistry profile, complete blood count, urinalysis, blood pressure, SDMA and thyroid level (paid for by the study).

What does enrolling my cat in this clinical trial involve?

Normal Cats: The study involves bringing your cat into the clinic twice within 1-2 weeks of each other: once for a hospital stay of 2.5 days and once for a drop off day visit. For the first hospital stay, your cat will have a jugular catheter placed under sedation prior to the start of the study to allow non-stressful blood sample collection. A single dose of gabapentin will be administered orally and blood samples and behavioral observations will be taken over a 36 hour period. For the second hospital stay, your cat will drop off early in the morning, have a single oral dose of gabapentin administered, have a blood sample taken at 3 and 8 hours after administration (a jugular catheter is not placed), and then go home at the end of the day.

CKD Cats: Once your cat is enrolled, the study involves bringing your cat into the clinic once for a drop off day visit. Your cat will drop off early in the morning, have a single oral dose of gabapentin administered, have a blood sample taken at 3 and 8 hours after administration, and then go home at the end of the day.

Client Compensation

If your cat is eligible, you will receive a complimentary CBC, chemistry, urinalysis, SDMA, blood pressure and thyroid level to confirm your cat’s health prior to participation. All costs of the visits and the medication are covered by the study.

Normal Cats: In addition, you will receive $500 towards care at the Veterinary Medical Center. If your cat develops other illnesses unrelated to the treatment, the study will not cover those costs.  Any complications associated with jugular catheter placement will be covered by the study.

CKD Cats: In addition, you will receive $80 towards care at the Veterinary Medical Center. The study will not cover costs associated with management of CKD or the development of other illnesses unrelated to the study.

Client Contact

If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire. 

Dr. Jessica Quimby (Quimby.19@osu.edu).