First-time or recurrent Staph skin infections in dogs

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Purpose:

The goal of this study is to identify potential targets for developing vaccines to prevent dogs from developing skin infections induced by a common dog bacterium, Staphylococcus pseudintermedius (Staph). We will investigate the relationship between the toxins produced by this bacterium, the clinical symptoms, and the immune response of the dogs. To study bacterial toxins causing canine skin disease, we need to collect bacteria from both healthy dogs without skin or ear disease and affected dogs. We also need to understand if affected dogs produce protective antibodies to the bacterial toxins identified from the bacteria collected from the skin lesions.

What qualifies my pet for this trial?

Two groups of dogs will be enrolled:bulldog running in water

Group 1 (healthy dogs):

  • Dogs between 1 and <10 years old.
  • Physical examination, bloodwork, and urine samples are within normal parameters
  • No prior treatments with ear medications, antibiotics for skin infections, or medicated shampoos, mousse, sprays, rinses etc. 

Group 2 (dogs with first-time or recurrent Staph skin infections):

  • Dogs between 1 and 10  years old.
  • Physical examination, bloodwork, and urine samples are within normal parameters.
  • First time or recurrent skin and/or ear infections.
  • Evidence of clinical signs of bacterial skin infection.
  • Absence of mites via deep skin scraping of the infected skin.

Exclusions

  • German Shepherd and German Shepherd mixes.
  • Patients with clinical signs of deep or mucocutaneous pyoderma, cellulitis, acral lick dermatitis, furunculosis, bacterial pseudomycetomas or other concurrent infectious causes of skin and ear disease.
  • Patients with risk factors for skin and ear Staph infections (e.g. immunodeficiency, leukopenia, receiving immunosuppressive medications, cancer, post-operative infections, and recent hospitalization within 30 days).
  • Patients that have received any forms of antibiotics, steroids, cyclosporine (Atopica), oclacitinib (Apoquel), within the preceding 14-day period.

What does enrolling in this clinical trial involve?

Group 1 (healthy):

The study includes one visit (enrollment), and the following procedures will be performed. Approximately 1 tablespoon of blood will be collected. A small amount of urine voided voluntarily by your pet will be collected for urinalysis. Sterile swabs will be pressed onto the oral mucosa, nostrils, and perineal skin for bacterial cultures.

Group 2 (dogs with first-time or recurrent Staph skin infections):

Approximately a tablespoon of blood will be collected at each of the 2 visits: enrollment (visit 1) and recheck appointment (visit 2).

The following procedures will be performed at the enrollment in addition to blood collection:

The contents from the infected skin will be collected on glass slides for the identification of bacteria. Sterile swabs will be pressed on to the infected skin, oral mucosa, nostrils, and perineal skin for bacterial cultures for bacterial culture and the presence of mites by using a dull skin spatula. A small amount of urine voided voluntarily by your pet will be collected for urinalysis.

Client Compensation

The appointment fees for both visits will be paid by the study.

At the initial visit, physical examination, routine bloodwork (both complete blood count and serum chemistry profile), urinalysis, and diagnostic tests for skin infections (cytology, deep skin scraping, and bacterial culture and susceptibility) will be performed at no cost to you.

During the recheck visit, physical examination and a complete blood count will be provided without additional charges. The physical examination findings and laboratory testing results will be provided to you.

For dogs with pyoderma, you will receive $100 hospital credit if you chose to enroll your dog in this study. Costs for recommended therapy will be the responsibility of the pet caretaker.

Contact:

Dr. Ching Yang
yang.4245@osu.edu


If you believe your pet may be eligible to enter this study,
please fill out a pre-screening questionnaire.

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