Evaluation of the effect of omeprazole in cats with chronic kidney disease (CKD)


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Purpose and Brief Explanation of Study:

Chronic kidney disease (CKD) is common in cats and may cause decreased appetite, nausea, and vomiting. Cats are often administered many medications to help alleviate gastrointestinal (GI) signs associated with CKD but there are very few studies in cats to determine if these therapies are warranted.

Objective of the trial:

The primary goal for this study is to evaluate if omeprazole is effective in alleviating GI signs in cats with CKD.

What qualifies my cat for enrollment in this in this trial?

Your cat is eligible to participate in this study if he / she has chronic kidney disease with no other concurrent uncontrolled disease.

What does enrolling my cat in this clinical trial involve?

Initial screening tests include complete blood count (CBC), chemistry panel, urine analysis, urine culture, total T4 thyroid screening, and blood pressure. During the 9 week study, you will record a daily log of your cat’s wellbeing. Your cat will receive treatment or placebo (randomly determined) for 14 days. Following the first medication (treatment or placebo), your cat will undergo a 14 day rest period in which you will continue to assess his/her response to treatment by completing the daily log. Following the rest period, your cat will receive the second medication (treatment or placebo) for 14 days, followed by another 14 day rest period. At the end of each medication or rest period, your cat will receive a physical exam and serum biochemistry will be assessed.

Client Compensation

This study is fully funded and for enrolled cats it will pay for:

  1. Physical examination
  2. Screening health lab work: complete blood count (CBC), chemistry panel, urine analysis, urine culture, thyroid screening
  3. Blood pressure
  4. Recheck examinations and serum biochemistry analysis (Total of 5 including above)

There is no additional monetary compensation for study participation.

Client Contact

If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire. 

Dr. Katie Tolbert, mtolber2@utk.edu

Dr. Jessica Quimby Quimby.19@osu.edu