Dogs with skin mast cell tumors

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Purpose and Brief Explanation of Study:

The proposed study will identify the efficacy of corticosteroids steroids in reducing microscopic mast cell tumor (MCT) tumor burden.  We seek new, evidence-based guidelines for the treatment of MCT, such as smaller surgical margin size, which could reduce the complications associated with surgery.

    What qualifies my dog for enrollment in this in this trial?

    • Have a solitary cutaneous MCT of at least 1cm in diameter
    • The mass has to be at a location that allows wide surgical excision
    • Have not been previously treated with steroids or currently on NSAID 
    • Have not had MCT recurrence

    Treatments with diphenhydramide or GI protectants (including omeprazole, ranitidine, famotidine, or sucralfate) will not be a cause of exclusion. Diagnosis of splenic or hepatic metastasis will not be a criterion of exclusion: the patient will be excluded if surgical excision or the use of prednisone does not seem appropriate (decision made by the clinician responsible of the case at presentation).

    What does enrolling my dog in this clinical trial involve? 

    Dogs enrolled in this study will undergo biopsies on planned surgical margins before and after treatment with prednisone. 
    At Day 0 (initial presentation) four (4) punch biopsies will be performed/collected while your dog is sedated.  This will happen while your dog is being marked with a permanent skin marker to show the margins of the MCT, as well as surgical margins.  For 7-10 day s, your dog will receive three oral medications; prednisone (1mg/kg/day), omeprazole (1mg/kg once a day) and diphenhydramine (2mg/kg twice a day). On the day of the MCT removal surgery (~day 7-10), additional biopsies will be collected after your dog has been anesthetized.  Three biopsies will be collected in the same fashion as on Day 0, and then the entire mass will be removed immediately following biopsy collection.

    Client Compensation

    Following your dog’s completion of the clinical trial, you will receive a credit of $50 for continued treatment of your dog at the Veterinary Medical Center. The clinical trial will cover the costs associated with biopsies including sedation and histopathology and neo-adjuvant therapy (prednisone and gastroprotectants).  Adverse events related to the study (biopsy site infection, dehiscence, local inflammation) will be covered by the clinical trial (up to $400). 
    Except for the specific financial support described here any tests or procedures unrelated to this study including treatment of conditions unrelated to the disease being evaluated are the responsibility of the owner.

    Client Contact

    If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire.
    Dr. Vincent Wavreille