Administration of Adriamycin (Doxorubicin)
- In dogs,
pretreat with diphenhydramine (Benadryl) 1mg/lb IM, or any other H 1-
antihistamine. No pretreatment is necessary in cats.
- Place an indwelling catheter and make sure it is patent.
- Dilute the doxorubicin to approximately 0.5 mg/ml (e.g.; 20 ml of saline per 10 mg of doxorubicin).
- Check catheter patency using plain 0.9% NaCl, do not use heparinized NaCl.
- Inject the doxorubicin slowly, over 20- 30 minutes.
every few ml to make sure catheter is patent. If the patency is
questionable, stop administration, remove the catheter, and use a
different vein. CALL US IMMEDIATELY IF THIS HAPPENS.
perivascular injection occur, remove the catheter and CALL OSU
IMMEDIATELY. There are new approaches to prevent necrosis from
perivascular doxorubicin, but they have to be implemented within hours
of the event. In the meantime, local injection of corticosteroids may
be beneficial. Ice packs should be applied on the affected area for 2-3
- If hypersensitivity reactions to the drug occur (head
shaking, pruritus, urticaria) discontinue the injection and give 0.5
mg/lb of diphenhydrameine (Benadryl) IM or IV. If the reaction
continues, give 1-2 mg/lb of dexamethasone IV. When the
hypersensitivity reaction subsides, continue injection of doxorubicinIf
you have any problems or questions call the Oncology Service at The
Ohio State University, College of Veterinary Medicine at 614-292-3551.