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Peer-reviewed Research Manuscripts (reverse chronological order) Total 282

  1. Lin, M., G. Grandinetti, L. Hartnell, D. Bliss, S.Subramaniamb, and Y. Rikihisa (2020) Host Membrane Lipids Are Trafficked to Membranes of Intravacuolar Ehrlichia chaffeensis.  Proc. Natl. Acad. Sci. In press.
  2. Bekebrede, H., M. Lin, O. Teymournejad, and Y. Rikihisa (2020) Discovery of in vivo Virulence Genes of Obligatory Intracellular Bacteria by Random Mutagenesis. Front. Cell. Infect. Microbiol. 10: 1-16.
  3. Teymournejad, O, M. Lin, H. Bekebrede, A. Kamr, R. E. Toribio, L. G. Arroyo, J. D.   Baird, and Y. Rikihisa (2020) A Novel Neorickettsia species, a bacterium that causes Potomac horse fever. mBio. 11: e03429-19.
  4. Xiong, X., M. Lin, W. Huang, and Y. Rikihisa (2019) Infection by Anaplasma  phagocytophilum requires recruitment of LDL-cholesterol by flotillin. mBio. 10: e02783-18. [PMCID: PMC6437059].
  5. Yan, Qi, M. Lin, W. Huang, O. Teymournejad, J. M. Johnson, F. A. Hays, Z. Liang, G. Li, and Y. Rikihisa (2018) An Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation. Proc. Natl. Acad. Sci. 115: E8977-E8986.
    [PMCID: PMC6156607]
  6. Rikihisa, Y. (2018) Role and Function of Type IV Secretion Systems in Anaplasma and Ehrlichia species. In: Type IV secretion in Gram-negative and Gram-positive bacteria. Ed. Steffen Backert & Elisabeth Grohmann.  “Current Topics in Microbiology and Immunology” (CTMI) by Springer International Publishing AG Switzerland. 413: 297-321.
  7. Teymournejad, O., M. Lin, and Y. Rikihisa. (2017) Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive oxygen Species Generation by Macrophages in a DNase X–Dependent Manner. mBio8: e01551-17. DOI: 10.1128/mBio.01551-17.
    PMID:  29162709
  8. Rikihisa, Y. (2017) Subversion of RAB5-Regulated Autophagy by the Intracellular Pathogen Ehrlichia chaffeensis. Small GTPase. PMID: 28650718 DOI:10.1080/21541248.2017.1332506
  9. Sharma, P., O. Teymournejad, and Y. Rikihisa (2017) Peptide Nucleic Acid Knockdown and Intra-Host Cell Complementation of Ehrlichia Type IV Secretion System Effector. Front. Cell. Infect. Microbiol. 7: 228 PMCID: PMC5461285 DOI: 10.3389/fcimb.2017.00228
  10. Lin, M., K. Bachman, Z. Cheng, S.C. Daugherty, S. Nagaraj, N. Sengamalay, S. Ott, Al  Godinez, L. J. Tallon, L. Sadzewicz, C. Fraser, J. C. Dunning Hotopp, and Y. Rikihisa. (2017) Analysis of Complete Genome Sequence and Major Surface Antigens of Neorickettsia helminthoeca, Causative Agent of Salmon Poisoning Disease. Microb. Biotechnol. 10:933-957. DOI: 10.1111/1751-7915.12731
  11. Pritt, B.S., Allerdice M. E. J., L. M. Sloan, C. D. Paddock, U. G. Munderloh, Y. Rikihisa, T. Tajima, S. M. Paskewitz, D. F. Neitzel, D. K. H. Johnson, E. Schiffman, J. P. Davis, C. S. Goldsmith, C. M. Nelson, S. E. Karpathy. (2017) Proposal to reclassify Ehrlichia muris as Ehrlichia muris subsp. muris subsp. nov. and description of Ehrlichia muris subsp. eauclairensis subsp. nov., a newly recognized tick-borne pathogen of humans Int. J. Syst. Evol. Microbiol. 67:2121-2126. doi: 10.1099/ijsem.0.001896
  12. Kumar, N., M. Lin, X. Zhao, S. Ott, I. Santana-Cruz, S. Daugherty, Y. Rikihisa, L. Sadzewicz, L. J. Tallon, C. M. Fraser, and J. C. Dunning Hotopp. (2016) Efficient Enrichment of Bacterial mRNA from Host-Bacteria Total RNA Samples. Scientific Reports, 5: 34850.
  13. Xiong, Q., H. Bekebrede, P. Sharma, L. G. Arroyo, J. D. Baird, and Y. Rikihisa.  (2016) An ecotype of Neorickettsia risticii causing Potomac Horse Fever in Canada. Appl. Environ. Microbiol. 82: 6030-6036.
  14. Lai, T-H, M.E. Parraga, E. Alvarez, and Y. Rikihisa.  (2016) Anaplasma platys Immunoblot Test Using Major Surface Antigens. Vector-Borne and Zoonotic Diseases. 16: 581-587.
  15. Lin, M., H. Liu, Q. Xiong, H. Niu, Z. Cheng, A. Yamamoto, and Y. Rikihisa (2016) Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase. Autophagy. 12: 1-22.
  16. Greiman, S., Y. Rikihisa, J. Cain, J. Vaughan, and V. Tkach (2016) Germs within worms: Localization of Neorickettsia sp. within life cycle stages of digenean Plagiorchis elegans. Appl. Environ. Microbiol. 82: 2356-2362.
  17. Ge, Y., H. Yin, Y. Rikihisa, W. Pan, and H. Yin. (2016) Molecular detection of tick- borne pathogens in Rickettsiales in goats and sheep from southeastern China. Vector- Borne and Zoonotic Dis. 16: 309-316.
  18. Klionsky, D.J., ---H. Niu, Y. Rikihisa---- >50 others (2016) Guidelines for the Use and         Interpretation of Assays for Monitoring Autophagy (3rd edition) Autophagy. 12: 1-222.
  19. Mohan-Kumar, D., M. Lin, Q. Xiong, M. J. Webber, C. Kural, and Y. Rikihisa. (2015) EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin. mBio. 6: e01541-15.
  20. Rikihisa, Y. (2015) Molecular Pathogenesis of Ehrlichia chaffeensis Infection. Ann. Rev.       Microbiol. 69: 283-304.
  21. Harasawa, R., H. Fujita, T. Kadosaka, S. Ando, and Y. Rikihisa (2015) Proposal for      ‘Candidatus Mycoplasma haemomuris subsp. musculi’ in mice, and ‘Candidatus Mycoplasma haemomuris subsp. ratti’ in rats. Int. J. Syst. Evol. Microbiol. 65: 734-737.
  22. Cheng, Z., M. Lin, and Y. Rikihisa (2014) Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and  glutamine. mBio. 5: e02141-14.
  23. Niu, H. and Y. Rikihisa (2014) Investigating interference with apoptosis induction by bacterial proteins. Methods in Molecular Biology. Ed. David O’ Callaghan and Annette Vergunst. 1197: 169-184.
  24. Mohan-Kumar, D., M. Yamaguchi, K. Miura, M. Lin, M. Los, J. F. Coy, and Y. Rikihisa  (2013) Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. PLoS Pathog. 9: e1003666
  25. Wang, P., P. Dadhwal, Z. Cheng, M. R. Zianni, Y. Rikihisa, F. T. Liang, and X. Li (2013) Borrelia burgdorferi Oxidative Stress Regulator BosR Directly Represses Lipoproteins Primarily Expressed in the Tick during Mammalian Infection. Mol. Microbiol. 89: 1140-1153.
  26. Niu, H., and Y. Rikihisa (2013) Ats-1, a novel bacterial molecule that links autophagy to bacterial nutrition. Autophagy, 9: 1-2.
  27. Niu, H., Q. Xiong, A. Yamamoto, M. Hayashi-Nishino, and Y. Rikihisa (2012) Autophagosomes Induced by a Bacterial Beclin 1-binding Protein Facilitate Obligatory Intracellular Infection. Proc. Natl. Acad. Sci. 109:20800-20807.
  28. Liu, H., W. Bao, M. Lin, H. Niu, and Y. Rikihisa (2012) Ehrlichia chaffeensis Type IV Secretion Effector ECH0825 is Translocated to Mitochondria, and Inhibits Apoptosis by upregulating Host MnSOD. Cell. Microbiol. 14: 1037-1050.
  29. Rahman, M. A., J. Matsuo, Z. Cheng and Y. Rikihisa (2012) Penicillin-Binding Protein of Ehrlichia chaffeensis: Cytokine Induction Through MyD88-Dependent Pathway. J. Infect. Dis. 206: 110-116.
  30. Xiong, Q.  and Y. Rikihisa (2012)   Subversion of NPC1 pathway of cholesterol transport by  Anaplasma phagocytophilum.  Cell. Microbiol. 14: 560-576.
  31. Cheng, Z. K. Miura, V. L. Popov, Y. Kumagai and Y. Rikihisa (2011) Insights into the CtrA Regulon in Development of Stress-resistance in Obligatory Intracellular Pathogen Ehrlichia chaffeensis.  Mol. Microbiol. 82: 1217-1234.
  32. Miura, K.,  J. Matsuo, M. A. Rahman, Y. Kumagai, X. Li and Y. Rikihisa (2011)  Ehrlichia chaffeensis Induces Monocyte Inflammatory Responses Through MyD88, ERK and NF-κB, but not through TRIF, IL-1R1/IL-18R1, or TLRs. Infect. Immun. 79: 4947-4956.
  33. Kumagai, Y., J. Matsuo, Z. Cheng, Y. Hayakawa, and Y. Rikihisa (2011) c-di-GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis Infect. Immun. 79: 3905-3912.
  34. Rikihisa, Y. (2011) Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum. Clin. Microbiol. Rev. 24: 469-489.
  35. Gibson, K., G. Pastenkos, S. Moesta, and Y. Rikihisa (2011) Neorickettsia risticii surface-exposed proteins: Proteomics identification, recognition by naturally-infected horses and strain variations. Vet. Res. 42: 71.
  36. Ge, Y. and Y. Rikihisa (2011) Subversion of host cell signalings by Orientia tsutsugamushi. Microbes Infect. 13: 638-648.
  37. Xiong, Q and Y. Rikihisa (2011) The prenylation inhibitor manumycin A reduces the viability of Anaplasma phagocytophilum. J. Med. Microbiol. 60: 744-749.
  38. Lai, T., N. G. Orellana, Y. Yuasa, and Y. Rikihisa (2011) Cloning of the Major OMP Expression Locus in Anaplasma platys and Seroreactivity of a Species-Specific Antigen. J.  Bacteriol. 193: 2924–2930.
  39. Lin, M., T. Kikuchi, H.M. Mottaz-Brewer, A. D. Norbeck, and Y. Rikihisa (2011) Global Proteomic Analysis of Two Tick-borne Emerging Zoonosis Agents: Anaplasma phagocytophilum and Ehrlichia chaffeensis. Front. Cell. Infect. Microbiol.  2:24.
  40. Gibson, K, Y. Kumagai, and Y. Rikihisa (2010) Proteomic Analysis of N. sennetsu Surface-exposed Proteins and Porin Activity of the Major Surface Protein P51. J. Bacteriol.  192: 5898-5905.
  41. Kumagai, Y, Matsuo, J., Y. Hayakawa, and Y. Rikihisa (2010) c-di-GMP Regulates Ehrlichia chaffeensis Surface Proteins and Intracellular Infection. J. Bacteriol. 192:4122-33.
  42. Rikihisa, Y., M. Lin, and H., Niu (2010) Type IV Secretion in Obligatory Intracellular Bacterium, Anaplasma phagocytophilum. Cell. Microbiol. 12:1213-21.
  43. Rikihisa, Y. (2010) Anaplasma phagocytophilum and Ehrlichia chaffeensis, subversive manipulaters of host cells. Nature Rev., Microbiol. 8: 328-339.
  44. Rikihisa, Y. (2010) Editorial: Diagnosis of canine monocytic ehrlichiosis: Development of advanced techniques to combat a global disease. Vet, J. 14: 250–251
  45. Niu, H., V. Kozjak-Pavlovic, T. Rudel, and Y. Rikihisa (2009) Anaplasma phagocytophilum Ats-1 is Imported into Host Cell Mitochondria and Interferes with Apoptosis Induction. PLoS Pathogens 6: e1000774. 
  46. Rikihisa, Y. and M. Lin. (2010) Ehrlichia/Anaplasma Type IV Secretion and Ank Proteins. Current Opinion Microbiol. 13: 59-66.
  47. O’Connor, T. P., J. Saucier, D. Daniluk, B. A. Stillman,  R. Krah, Y. Rikihisa, Q. Xiong, M.J. Yabsley, D.S. Adams, P. V.P. Diniz, E. B. Breitschwerdt, S. Gaunt, R. Chandrashekar. (2010) Evaluation of peptide- and recombinant protein-based assays for detection of anti-Ehrlichia ewingii antibodies in experimentally and naturally infected dogs. J. Am.Vet. Res. 71:1195-1200.
  48. Rikihisa, Y. (2010) Molecular events involved in cellular invasion by ehrlichia and anaplasma.  Vet. Parasitol. 167: 155-166.
  49. Kawahara, K, T. Tajima, H. Torii, M. Yabutani, J. Ishii, M. Harasawa, E. Isogai and Y. Rikihisa (2009) Ehrlichia chaffeensis Infection of Sika Deer from Nara Park, Japan. Emerg. Infect. Dis. 15: 1991-1993.
  50. Lin, M., C. Zhang, K. Gibson, and Y. Rikihisa (2009) Analysis of Complete Genome Sequence of Neorickettsia risticii: the Causative Agent of Potomac Horse Fever. Nuc. Acid Res. 37: 6076-6091.
  51. Xiong, Q., M. Lin., and Y. Rikihisa (2009) Anaplasma phagocytophilum acquires cholesterol through low-density lipoprotein uptake pathway. PLoS Pathogens. 5:e1000329
  52. Grieg, J., Y. Rikihisa, and M. Wellman (2009) Importance of the use of PCR in confirmation of Ehrlichia ewingii infection. Vet. Clin. Pathol. 38: 406-410.
  53. Rikihisa, Y. M. Lin, H. Niu, and Z. Cheng (2009) Type IV Secretion System of Anaplasma phagocytophilum and Ehrlichia chaffeensis. Ed. by K.E. Hechemy  and D. A. Raoult. Ann N Y Acad Sci. 1166: 106-111.
  54. Miura. K. and Y. Rikihisa (2009) Liver microarray profiles associated with strain-specific Ehrlichia chaffeensis–induced hepatitis in mice.  Infect. Immun. 77: 245-254.
  55. Lai, T-H., Y. Kumagai, M. Hyodo, Y. Hayakawa, and Y. Rikihisa. (2009) Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic di-GMP in host-cell infection. J. Bacteriol. 191: 693-700. Selected to be highlighted by a Commentary.
  56. Bao, W.†, H. Kumagai†, M. Niu, Y. Yamaguchi, K. Miura, and Y. Rikihisa. (2009) Four VirB6 Paralogs and VirB9 are Expressed and Interact in Ehrlichia chaffeensis-containing vacuole. J. Bacterial. 191; 278-286. (†equally contributed)
  57. Unver, A., Y. Rikihisa, M. Karaman, and H. Ozen. (2008) An acute severe ehrlichiosis in a dog experimentally infected with a new virulent strain of Ehrlichia canis. Clin Microbiol. Infect. Dis. 15 (Suppl.1) 1-3.
  58. Delos Santos, J. R., M. Oglesbee M, Y. Rikihisa., R. W. Stich (2008) Pathologic Evidence of Ehrlichiosis in Calves Inoculated with Ehrlichia chaffeensis Animal Biodiversity and Emerging Diseases: Ann. N.Y. Acad. Sci. 1149: 103–106.
  59. Schaefer, J. J., J. Kahn, G. R. Needham, Y. Rikihisa, S. A. Ewing and R. W. Stich. (2008) Antibiotic Clearance of Ehrlichia canis from Dogs Infected by Intravenous Inoculation of Carrier Blood. Animal Biodiversity and Emerging Diseases: Ann. N.Y. Acad. Sci. 1149: 263–269.
  60. Mottaz-Brewer, Heather M., A. D. Norbeck, J. N. Adkins, N. P. Manes, C. K. Ansong, L. Shi, Y. Rikihisa, T. Kikuchi, S. W. Wong, R. D. Estep, F. Heffron, L. Pasa-Tolic, and R. D. Smith (2008) Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems. J. Biomol. Tech. 19: 285-295.
  61. Huang, H†., M. Lin†, X. Wang, T. Kikuchi, H. Mottaz, A. Norbeck, and Y. Rikihisa (2008) Proteomic Analysis of and Immune Responses to Ehrlichia chaffeensis Lipoproteins. Infect. Immun. 76: 3405-3414. (†equally contributed)
  62. Gibson, K. E. and Y. Rikihisa (2008) Molecular link of different stages of the trematode host of Neorickettsia risticii. Environ. Microbiol. 10: 2064-2073.
  63. Kumagai, Y., H. Huang, and Y. Rikihisa (2008) Expression and Porin Activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis Development. J. Bacteriol. 190: 3597-3605.
  64. Cheng, Z.,  X. Wang, and Y. Rikihisa (2008) Regulation of Type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein. J. Bacteriol. 190: 2096-2105.
  65. Zhang, C., Q. Xiong, T. Kikuchi, and Y. Rikihisa (2008) Identification of 19 polymorphic major outer membrane protein genes and their immunogenic peptides in Ehrlichia ewingii for use in a serodiagnostic assay. Clin. Vaccine Immunol. 15: 402-411.
  66. Xiong, Q., W. Bao, Y. Ge, and Y. Rikihisa (2008)  Ehrlichia ewingii Infection Delays Spontaneous Neutrophil Apoptosis  Through Stabilization of Mitochondria. J. Infect. Dis. 197:1110-1118.
  67. Niu, H., M. Yamaguchi, and Y. Rikihisa (2008) Subversion of cellular autophagy by Anaplasma phagocytophilum. Cell. Microbiol., 10: 593-605.
  68. Delos Santos, J..R., K. Boughan, W.G. Bremer, B. Rizzo B, J.J. Schaefer, Y. Rikihisa, G. R. Needham, L.A. Capitini, D. E. Anderson, M. Oglesbee M, S. A. Ewing, R. W. Stich (2007) Experimental infection of dairy calves with Ehrlichia chaffeensis. J Med Microbiol. 56:1660-1668.
  69. Xiong, Q., X. Wang, and Y. Rikihisa. (2007) High-Cholesterol Diet Facilitates   Anaplasma phagocytophilum Infection and Up-regulates MIP-2 and CXCR2 Expression in Apolipoprotein E-Deficient Mice. J. Infect. Dis. 195: 1497-1503.
  70. Wang, X., Z. Cheng, C. Zhang, T. Kikuchi, and Y. Rikihisa (2007) Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: Involvement of the DNA binding protein ApxR. J. Bacteriol. 189:8651-8659.
  71. Ge, Y. and Y. Rikihisa (2007) Identification of Novel Surface Proteins of Anaplasma phagocytophilum by Affinity Purification and Proteomics.  J. Bacteriol. 189: 7819-7828.
  72. Schaefer, J. J., J. Kahn, G. R. Needham, Y. Rikihisa, S. A. Ewing and R. W. Stich (2007) Antibiotic clearance of Ehrlichia canis from dogs infected by intravenous inoculation of carrier blood. Antimicrob. Agents Chemother., 51:3394-3396.
  73. Lin, M., A. den Dulk-Ras, and P. J. J. Hooykaas, and Y. Rikihisa (2007) Anaplasma phagocytophilum AnkA Secreted by Type IV Secretion System is Tyrosine Phosphorylated by Abl-1 to Facilitate Infection. Cell. Microbiol.  9: 2644-2657.
  74. Wang, X., T. Kikuchi, and Y. Rikihisa. (2007) Proteomic Identification of A Novel Anaplasma phagocytophilum DNA Binding Protein That Regulates A Putative Transcription Factor. J. Bacteriol.  189: 4880-4886.
  75. Ge, Y. and Y. Rikihisa. (2007) Surface-exposed proteins of Ehrlichia chaffeensis. Infect. Immun. 75: 3833-3841.
  76. Miura, K. and Y. Rikihisa (2007) Virulence potential of Ehrlichia chaffeensis strains of Distinct Genome Sequences. Infect. Immun. 75: 3604-3613.
  77. Lin, M and Y. Rikihisa (2007) Degradation of p22phox and Inhibition of Superoxide Generation by  Ehrlichia chaffeensis in Human Monocytes. Cell. Microbiol. 9:861-874.
  78. Kumagai, Y. Cheng, Z., M, Lin, and Y. Rikihisa (2006) Biochemical Activities of Three Pairs of Ehrlichia chaffeensis Two-Component Regulatory System Involved in Inhibition of Lysosomal Fusion. Infect. Immun 74: 5014-5022.
  79. Unver, A., H. Huang, and Y. Rikihisa, (2006) Cytokine Gene Expression by Peripheral Blood Leukocytes in Dogs Experimentally Infected with a New Virulent Strain of Ehrlichia canis.  Ed. by K.E. Hechemy  and D. A. Raoult. Ann N Y Acad Sci. 1078: 482-486.
  80. Perez, M.,  M. Bodor, C. Zhang, Q. Xiong, and Y. Rikihisa (2006) Human Infection with Ehrlichia canis Accompanied By Clinical Signs In Venezuela. Ann N Y Acad Sci. 1078: 110-117.
  81. Rikihisa, Y. (2006) New Findings on Members of the Family Anaplasmataceae of Veterinary Importance. Ann N Y Acad Sci.  1078:438-445.
  82. Ge, Y  and  Y. Rikihisa (2006) Anaplasma  phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of  multiple apoptotic pathways. Cell. Microbiol. 8: 1406-1416.
  83. Cheng, Z., Y. Kumagai, M. Lin, C. Zhang, and Y. Rikihisa (2006) Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell Microbiol. 8: 1241-1252.
  84. Dunning Hotopp, J. M. Lin, R. Madupu, J. Crabtree, S. Angiuoli, J. Eisen, R. Sesahdri, Q. Ren, T. R. Utterback, S. Smith, M. Lewis, H. Khouri, C. Zhang, N. Hua, Q. Lin, N. Ohashi, N. Zhi, W. Nelson, L. M. Brinkac, R. J. Dodson, M. J. Rosovitz, J. Sundaram, S. C. Daugherty, T. Davidsen, A. Durkin, M. Gwinn, D. H. Haft, J. D. Selengut, S.A. Sullivan, N. Zafar, L. Zhou, F. Benahmed, H. Forberger, R. Halpin, S. Mulligan, J. Robinson,Y. Rikihisa, H. Tettelin (2006) Comparative Genomics of Emerging Human Ehrlichioisis Agents. PLoS Genetics. 2: e21 1-16.
  85. Lin, Q. C. Zhang, and Y. Rikihisa (2006) Analysis of p44 recombination intermediate in Anaplasma phagocytophilum and in E. coli using plasmid encoding p44 expression and donor loci. Infect. Immun. 74: 2052-2062.
  86. Rikihisa, Y. (2006) Ehrlichia subversion of host innate immune responses. Current Opinion Microbiol. 9: 95-101.
  87. Huang, H., A. Unver, M. J. Perez, N. G. Orellana, and Y. Rikihisa (2006) Prevalence and molecular analysis of Anaplasma platys from dogs in Lara, Venezuela. Brazilian J. Microbiol. 36: 211-216.
  88. Wang, X., T. Kikuchi, and Y. Rikihisa (2006) Two neutralization sites defined by epitope-mapping and monoclonal antibody inhibition analysis on P44 major surface proteins of Anaplasma phagocytophilum. Infect. Immun. 74: 1873-1882.
  89. Perez, M.,  M. Bodor, C. Zhang, and  Y. Rikihisa (2006) Human infection with Ehrlichia canis accompanied by Clinical Signs In Venezuela. Ann.New York Acad. Sci., in press.
  90. Unver, A., H. Huang, and Y. Rikihisa, (2006) Cytokine Gene Expression by Peripheral Blood Leukocytes in Dogs Experimentally Infected with a New Virulent Strain of Ehrlichia canis.  Ann. New York Acad. Sci., in press.
  91. Rikihisa, Y.  (2006)  New Findings on Members of the Family Anaplasmataceae of Veterinary Importance. Ann. New York Acad. Sci., in press.
  92. Kawahara, M, Y. Rikihisa, Q. Lin, E. Isogai, K. Tahara, A. Itagaki, Y. Hiramitsu, and T. Tajima. (2006) Genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale and Ehrlichia species in wild deer on two major islands in Japan. Appl. Env. Microbiol. 72: 1102-1109.
  93. Niu, H,  Y. Rikihisa, M. Yamaguchi, and  N. Ohashi (2006) Differential Expression of VirB9 and VirB6 During Lifecycle of Anaplasma phagocytophilum in Human Leukocytes is Associated with Differential Binding and Avoidance of Lysosome Pathway. Cell Microbiol. 8: 523-534.
  94. Tajima, T. and Y. Rikihisa. (2005) Cytokine responses in Ehrlichia canis-infected dogs.  Ann. New York Acad. Sci., 1063:429-32.
  95. Unver, A., Y. Rikihisa,  K. Borku,  Y. E. Ozkanlar,  and B. Hanedan. (2005)  Molecular detection and characterization of Ehrlichia canis from dogs in Turkey. Berl. Münch.Tierärztl.Wschr. 118, 300-304.
  96. Bremer WG, Schaefer JJ, Wagner ER, Ewing SA, Rikihisa Y, Needham GR, Jittapalapong S, Moore DL, Stich RW. (2005) Transstadial and intrastadial experimental transmission of Ehrlichia canis by male Rhipicephalus sanguineus. Vet Parasitol. 131: 95-105.
  97. Lin, Q. and Y. Rikihisa. (2005) Establishment of cloned Anaplasma phagocytophilum and analysis of p44 Gene conversion within infected horse and SCID mice. Infect. Immun. 73:5106-5114.
  98. Gibson, K. E. Y. Rikihisa, C. Zhang, and C. Martin (2005) Neorickettsia risticii is vertically transmitted in the trematode Acanthatrium oregonense and horizontally transmitted to bats. Environ. Microbiol. 7: 203-212.
  99. Ge, Y., K. Yoshiie, F. Kuribayashi, M. Lin and Y. Rikihisa (2005) Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential, and prevention of caspase 3 activation. Cell. Microbiol. 7: 29-38.
  100. Wang, X., Y. Rikihisa, T. Lai, Y. Kumagai, N. Zhi, and S. M. Reed (2005) Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses. Infect. Immun. 72: 6852-6859.
  101. Lin, Q., Y. Rikihisa. R. F. Massung, and Z. Woldehiwet (2004) Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions. Infect. Immun. 72: 5574-5581.
  102. Wang, X., Y. Rikihisa, T. Lai, Y. Kumagai, N. Zhi, and S. M. Reed (2004) Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses. Infect. Immun. 72: 6852-6859.
  103. Lin, Q., Y. Rikihisa. R. F. Massung, and Z. Woldehiwet (2004) Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions. Infect. Immun. 72: 5574-5581.  
  104. Rikihisa, Y., C. Zhang, M. Kanter, Z. Cheng, N. Ohashi, and T. Fukuda (2004) Analysis of p51, groESL, and the major antigen P51 in various species of Neorickettsia, an obligatory intracellular bacterium of trematodes and mammals. J. Clin. Microbiol. 42: 3823-3826.     
  105. Kawahara, M., Y. Rikihisa, E. Isogai, M. Takahashi, H. Misumi, C. Suto, S. Shibata, C. Zhang and M. Tsuji. (2004) Ultrastructure and phylogenetic analysis of ‘Candidatus Neoehrlichia mikurensis’ in the family Anaplasmataceae isolated from wild rats and found in Ixodes ovatus ticks. Int. J. Syst. Evol. Microbiol. 54: 1837-1843.
  106. Lin, Q., Y. Rikihisa, S.Felek, X. Wang, R. F. Massung, and Z. Woldehiwet. (2004) Anaplasma phagocytophilum has functional msp2 distinct from p44. Infect Immun. 72: 3883-3889.
  107. Wagner, E., W.G. Bremer, Y. Rikihisa, S.A. Ewing, G.R. Needham, A. Unver, X. Wang, R.W. Stich. (2004) Development of a p28-based PCR assay for Ehrlichia chaffeensis. Mol. Cell Probes. 18:111-116.
  108. Zhang, C., and Y. Rikihisa. (2004) Proposal to transfer ‘Aegyptianella ranarum’, an intracellular bacterium of frog red blood cells, to the family Flavobacteriaceae as ‘Candidatus Hemobacterium ranarum’ comb. nov.  Environ. Microbiol. 6: 568-573.
  109. Felek, S., S.Telford IIIrd,  R. C. Falco,  and Y. Rikihisa (2004) Sequence analysis of p44 homologs expressed by Anaplasma phagocytophilum in infected ticks feeding on naïve hosts and in mice infected by tick attachment. Infect. Immun. 72: 659-666.
  110. Lin, M. and Y. Rikihisa (2004) Ehrlichia chaffeensis Down Regulates Surface Toll-like Receptors 2/4 and CD14 and Transcription Factors PU.1 in Host Monocytes Subsequent to Inhibition of p38 MAPK, ERK 1/2, and NF-kB Pathways. Cell. Microbiol. 6:175-186.
  111. Lin, M. and Y. Rikihisa (2003) Obligate intracellular parasitism by human monocytic and granulocytic ehrlichiosis agents involves caveolae and glycosylphosphatidylinositol-anchored proteins. Cell. Microbiol. 5: 809-820.
  112. Rikihisa, Y., C. Zhang, and B. M. Christensen. (2003) Molecular characterization of Aegyptianella pullorum (Rickettsiales, Anaplasmataceae). J. Clin. Microbiol. 41: 5294-5297.
  113. Lin, Q., Y. Rikihisa, N. Ohashi, and N. Zhi (2003) Mechanisms of Variable p44 Expression by Anaplasma phagocytophilum. Infect. Immun. 71: 5650-5661.
  114. Felek, S, H. Huang, and Y. Rikihisa (2003) Sequence and expression analysis of virB9 of the type IV secretion system of Ehrlichia canis strains in ticks, dogs, and cultured cells. Infect. Immun. 71: 6063-6067.
  115. Lin, M. and Y. Rikihisa (2003) Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for Lipid A biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 71: 5324-5331.
  116. Felek, S., R. Greene, and Y. Rikihisa. (2003) Transcriptional analysis of p30 major outer membrane protein genes of Ehrlichia canis in naturally infected ticks and sequence analysis of p30-10 of E. canis from diverse geographic regions. J. Clin. Microbiol. 41: 886-888.
  117. Okada, H., H. Usuda, T.Tajima, M. Kawahara, T. Yoshino, and Y. Rikihisa. (2003) Detection and localization of Ehrlichia sp. HF strain most closely related to Ehrlichia chaffeensis in a mouse model by in situ hybridization. J. Comp. Pathol. 128: 182-187.
  118. Rikihisa, Y. (2003) Mechanisms to create a safe haven by members of the family Anaplasmataceae. Ann. New York Acad. Sci., 990: 548-555.
  119. Unver, A., Y. Rikihisa, M. Kawahara, and S. Yamamoto. (2003). Analysis of 16S rRNA Gene Sequences of Ehrlichia canis, Anaplasma platys, and Wolbachia Species from the Blood of Dogs in Japan. Ann. New York Acad. Sci., 990: 692-698.
  120. Harasawa, Y., M. Kawahara, and Y. Rikihisa. (2002) Characteristics of the 16S-23S rRNA intergenic spacer region of Mycoplasma haemomuris, previously classified as Haemobartonella muris. J.Vet.Med.Sci. 64: 1161-1164.
  121. Zhi, N., N. Ohashi, and Y. Rikihisa. (2002) Activation of a p44 pseudogene in Anaplasma phagocytophila by bacterial RNA splicing: A novel mechanism for posttranscriptional regulation of a multigene family encoding immunodominant major outer membrane proteins. Mol. Microbiol. 46:135-146.
  122. Lin, Q. N. Zhi, N. Ohashi, H. W. Horowitz, M.E. Aguero-Rosenfeld, J. Ruffalli, G. P.Wormser, and Y. Rikihisa. (2002) Diverse p44 Gene expression by Anaplasma phagocytophila in acutely infected patients. J. Clin. Microbiol. 40: 2981-2988.
  123. Kim, H-Y. J. Mott, N. Zhi, T. Tajima, Y. Rikihisa. (2002) Cytokine gene expression by peripheral blood leukocytes in horses during experimental infection with Anaplasma phagocytophila. Clin. Diag. Lab. Immunol. 9: 1079-1084.
  124. Liddell, A.M., Sumner JW, Paddock CD, Rikihisa Y, Unver A, Buller RS, and Storch GA (2002) Reinfection with Ehrlichia chaffeensis in a Liver Transplant Recipient. Clin. Infect. Dis. 34: 1644-1647.
  125. Unver, A., Y. Rikihisa, R.W. Stich, N. Ohashi, and S. Felek. (2002) The omp-1 Major Outer Membrane Multigene Family of Ehrlichia chaffeensis is Differentially Expressed in Canine and Tick Hosts. Infect. Immun. 70: 4701-4704.
  126. Kim, Y-H, and Y. Rikihisa. (2002) Roles of p38 Mitogen-Activated Protein Kinase, NF-kB and Protein Kinase C in Proinflammatory Cytokine mRNA Expression by Human Peripheral Blood Leukocytes in Response to Anaplasma phagocytophila. Infect. Immun. 70: 4132-4141.
  127. Zhang, C., and Y. Rikihisa. (2002) Evaluation of Sensitivity and Specificity of Mycoplasma haemomuris-Specific PCR. Comp. Med. 52: 204-206.
  128. Neimark, H., K-E Johansson, Y. Rikihisa, and J. Tilly. (2002) Revision of haemotrophic Mycoplasma species names. Int. J. Syst. Evol. Microbiol. 52: 683.
  129. Stich, R. W. Y.Rikihisa, S.A. Ewing, G.R. Needham, D. L. Grover and S. Jittapalapong (2002) Detection of Ehrlichia canis in Canine Carrier Blood and in Individual Experimentally Infected Ticks with a p30-Based PCR Assay . J. Clin.Microbiol. 40: 540-546.
  130. Ohashi, N., N. Zhi, Q. Lin, and Y. Rikihisa. (2002) Characterization and Transcriptional Analysis of Gene Clusters for a Type IV Secretion Machinery in Human Granulocytic and Monocytic Ehrlichiosis Agents. Infect. Immun. 70: 2128-2138.
  131. Zhi, N., N. Ohashi, T. Tajima, J. Mott, R. W. Stich, D. Grover, S. R. Telford III, Q. Lin,  and Y. Rikihisa. (2002) Transcript Heterogeneity of p44 Multigene Family in Human Granulocytic Ehrlichiosis Agent Transmitted by Ticks. Infect. Immun. 70: 1175-1184.
  132. Mott, J., Y. Rikihisa and S. Tsunawaki (2002) Effects of Anaplasma phagocytophila on NADPH Oxidase Components in Human Neutrophils and HL-60 cells. Infect. Immun. 70: 1359-1366.
  133. Mott, J, Y. Muramatsu, E. Seaton, C. Martin, S. Reed, and Y. Rikihisa. (2002) Molecular Analysis of Ehrlichia risticii in Adult Aquatic Insects in Pennsylvania, in Horses Infected by Ingestion of Insects, and Isolated in Cell Culture. J. Clin. Microbiol. 40: 690-693.
  134. Lin, M., M. X. Zhu, and Y. Rikihisa. (2002) Activation of PLC-g2, Increase in Cytosolic Free Calcium, Recruitment of PLC-g2 and Tyrosine Phosphorylated Proteins to Its Inclusion by Ehrlichia chaffeensis for Intracellular Growth in THP-1 Cells. Infect. Immun. 70: 889-898.
  135. Dumler, J. S., A. F. Barbet, C. P. J. Bekker, G.A. Dasch, G. H. Palmer, S. C. Ray, Y. Rikihisa, and F.R. Rurangirwa (2001) Reorganization of Genera in the Families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; Unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; Description of six New Species Combinaions; and Designation of Ehrlichia equi and "HGE agent" as Subjective Synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165.
  136. Neimark, H., K-E Johansson, Y. Rikihisa, and J. Tilly. (2001) Proposal to transfer some members of the genera Haemobartonella and Eperythrozoon to the Genus Mycoplasma with descriptions of ‘Candidatus Mycoplasma hemofelis’, ‘Candidatus Mycoplasma hemomuris’, ‘Candidatus Mycoplasma hemosuis’ and ‘Candidatus Mycoplasma wenyonii’. Int. J. Syst. Evol. Microbiol. 51: 891-899.
  137. Okada, H., T. Tajima, M. Kawahara, and Y. Rikihisa. (2001) Ehrlichial proliferation in endothelial cells and lethal liver necrosis in immunocompetent mice experimentally infected with HF strain most closely related to Ehrlichia chaffeensis. J. Comp. Pathol. 124: 165-171.
  138. Felek, S., A. Unver, R.W. Stich, and Y. Rikihisa. (2001) Sensitive detection of Ehrlichia chaffeensis in cultured cells, blood, and ticks by RT-PCR. J. Clin. Microbiol. 39: 460-463.
  139. Ohashi, N., Y. Rikihisa, and A. Unver. (2001) Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis. Infect. Immun. 69: 2083-2091.
  140. Unver, A., Felek, S., N. Zhi, C. Paddock, H. W. Horowitz, G. P.Wormser, and Y. Rikihisa. (2001) Western Immunoblot Analysis of HME and HGE dual reactive sera. J. Clin. Microbiol. 39: 3982-3986.
  141. Unver, A., M., N. Ohashi, T. Tajima,  R.W. Stich, D. Grover, and Y. Rikihisa (2001). Transcriptional Analysis of p30 Major Outer Membrane Multigene Family of Ehrlichia canis in Dogs, Ticks, and Cell Culture at Different Temperatures.  Infect. Immun. 69: 6172-6178.
  142. Unver, A., M. Perez, N..Orellana, H. Huang, and Y. Rikihisa. (2001) Molecular and antigenic comparison of  Ehrlichia canis from dogs, ticks, and a human in Venezuela. J. Clin. Microbiol. 39: 2788-2793.
  143. Yoshiie, K., Kim, Y-H, Mott, J., and Y. Rikihisa (2000) Intracellular infection by human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Infect. Immun. 68: 1125-1133.
  144. Mott, J., and Y. Rikihisa. (2000) Human granulocytic ehrlichiosis agent inhibits superoxide anion generation by human neutrophils. Infect. Immun. 68: 6697-6703.
  145. Walker, D.H., J. Bakken, P. Brouqui, J. Childs, L. Cullman, J. Dawson, J.S. Dumler, V. Fingerle, J. Goodman, P. Hogan, W. Hogrefe, J. Liz, L.A. Magnarelli, J. Markley, R. Massung, E.J. Masters, C. Murphy, J. Olano, C. Padoock, M. Petrovec, Y. Rikihisa, S. Standaert, G. P. Wormser, X-Y. Yu, T.A. Zupanic. (2000) Consensus on Diagnosis of Human Ehrlichioses. ASM News. 66: 287-290. (authors are listed in alphabetical order except for Walker, D.H. the organizer)
  146. Kanter, M., J. Mott, N. Ohashi, B. Fried, S. Reed, Y. Lin, and Y. Rikihisa. (2000)  Analysis of 16S rRNA and 51-kDa antigen gene and transmission in mice of  Ehrlichia risticii in virgulate trematodes from Elimia livescens snails in Ohio. J. Clin. Microbiol. 38: 3349-3358.
  147. Rikihisa, Y.  (2000) Diagnosis of Emerging Ehrlichial Diseases of Dogs, Horses, and Humans. Editorial. J. Vet. Int. Med. 14: 250-251.      
  148. Tajima, T., N. Zhi, Q. Lin, Y. Rikihisa, H.W. Horowitz, J. Ralfalli, G.P. Womser, and K. Hechemy. (2000) Enzyme-linked immunosorbent assay using major outer membrane protein of the human granulocytic ehrlichiosis agent. Clin. Diag. Lab. Immunol. 7: 652-657.
  149. Sumner, J.W., G.A. Storch, R.AS. Buller, A.M. Liddell, S.L. Stockham, Y.Rikihisa, S. Messenger, J.E. Childs, and C.D. Paddock. (2000) PCR amplification and phylogeneticc analysis of groESL operon sequences from Ehrlichia ewingii and Ehrlichia muris. J. Clin. Microbiol. 38: 2746-2749.
  150. Kim, Y-H, and Y. Rikihisa. (2000) Expression of interleukin-1β, tumor necrosis factor-α, and IL-6 in human peripheral blood leukocytes exposed to viable  human granulocytic ehrlichiosis agent or recombinant major surface antigen P44. Infect. Immun. 68: 3394-3402.
  151. Shibata, S., M. Kawahara, Y. Rikihisa, H. Fujita, Y. Watanabe, C. Suto, and T.Ito (2000) New Ehrlichia sp. closely related with E. chaffeensis isolated from Ixodes ovatus ticks in Japan. J. Clin. Microbiol. 38: 1331-1338.
  152. Buller, R.S., M. Arens,  S. P. Hmiel, C. Paddock, J.W. Sumner, Y. Rikihisa, A. Unver, M. Graudreauls-Keener, F. A. Marinian, A. M. Liddell, N. Schmulewitz, and G. Storch. (1999) Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. New Engl. J. Med. 341: 148-155.
  153. Zhi, N., N. Ohashi, and Y. Rikihisa. (1999) mRNA expression of the multigene family encoding 44-kDa major outer membrane proteins of the human granulocytic ehrlichiosis agent. J. Biol. Chem. 274:17828-17836.
  154. Barnewall, R., N. Ohashi, and Y. Rikihisa (1999) Ehrlichia chaffeensis and E. sennetsu, but not the Human granulocytic ehrlichiosis agent colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect Immun. 67: 2258-2265.
  155. Mott, J., R. Barnewall, and Y. Rikihisa. (1999) Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect. Immun. 67: 1368-1378.
  156. Kawahara, M., T. Ito, C. Suto, S. Shibata, Y. Rikihisa, K. Hara, and K. Hirai. (1999) Comparison of Ehrlichia muris isolated from wild mice and ticks, and serologic evidence of human and animal exposure to E. muris. J. Clin.Microbiol. 37: 1123-1129.
  157. Unver, A.,  Y. Rikihisa, N. Ohashi. (1999) Western and dot blotting analysis of Ehrlichia chaffeensis IFA-positive and negative sera using native and recombinant E. chaffeensis and E. canis antigen. J. Clin. Microbiol. 37: 3888-3895.
  158. Rikihisa, Y.  (1999)  Clinical and biological aspects of infections caused by Ehrlichia chaffeensis. Microb. Infect. 1: 367-376.
  159. Ohashi, N., N. Zhi, Y. Zhang, and Y. Rikihisa. (1998) Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect. Immun. 66:132-139.
  160. Barlough, J.E., G.H. Reubel, J.E. Madigan, L.K. Vredevoe, P.E. Miller, and Y. Rikihisa. (1998) Detection of Ehrlichia risticii, the agent of Potomac horse fever, in freshwater stream snails (Pleuroceridae: Juga spp.) of Northern California. J. Appl. Environ. Microbiol. 64: 2888-2893.
  161. Zhi, N., N. Ohashi, Y. Rikihisa, H.W. Horowitz, G.P. Womser, K. Hechemy. (1998) Cloning and expression of 44-kDa major outer membrane protein antigen gene of human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis. J. Clin. Microbiol. 36: 1666-1673.
  162. Zhang, Y., N. Ohashi, and Y. Rikihisa. (1998) Cloning of the heat shock protein 70 (HSP70) of Ehrlichia sennetsu and differential expression of HSP70 and HSP60 mRNA after temperature upshift. Infect. Immun. 66: 3106-3112.
  163. Horowitz, H.W., M.E. Aguero-Rosenfeld, D.F. McKenna, D. Holmgren, T-Z. Hsieh, S. A. Varde, S.J. Dumler, J. M. Wu, I. Schwartz, Y. Rikihisa, and G. P. Wormser. (1998) Clinical and laboratory spectrum of culture-proven human granulocytic ehrlichiosis: Comparison with cculture-negative cases. Clin. Infect. Dis. 27: 1314-1317.
  164. Lee, E. and Y. Rikihisa.  (1998)  Protein kinase A-mediated inhibition of interferon-gamma-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia   chaffeensis. Infect. Immun. 66: 2514-2520.
  165. Kim, Y-H, and Y. Rikihisa. (1998) Characterization of monoclonal antibodies against the major outer membrane protein of human granulocytic ehrlichiosis agent. J. Clin. Microbiol. 36: 3278-3284.
  166. Ohashi, N., Unver, A., and Y. Rikihisa. (1998) Cloning and characterization of multigenes encoding immunodominant 30-kDa major outer membrane protein of Ehrlichia canis and application of the recombinant protein for serodiagnosis. J. Clin. Microbiol. 36:2671-2680.
  167. Rikihisa, Y., N. Zhi, G. Wormser, B. Wen, H.W. Horowitz, and K.E. Hechemy.  (1997) Direct isolation and cultivation of human granulocytic ehrlichia from a human patient.  J. Infect. Dis.  175: 210-213.
  168. Barlough, J.E., Y. Rikihisa, and J.E. Madigan.  (1997)  Nested polymerase chain reaction for detection of Ehrlichia risticii genomic DNA in infected horses.  Vet. Parasitol.  68: 367-373.
  169. Zhang, Y., N. Ohashi, E. Lee, and Y. Rikhisa. (1997) Ehrlichia sennetsu groE operon and antigenic properties  of the groEL homolog. FEMS Immunol. Med. Microbiol. 18: 39-46.
  170. Rikihisa, Y., M. Kawahara, B. Wen, G. Kociba, P. Fuerst, F. Kawamori, C. Suto, S. Shiba, and M. Futohashi.  (1997)  Western immunoblot analysis of Haemobartonella muris and comparison of 16SrDNA sequences of H. muris, H. felis, and Eperythrozoon suis.  J. Clin. Microbiol. 35: 823-829.
  171. Barnewall, R.E., Y. Rikihisa, and E.H. Lee.  (1997)  Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor.  Infect. Immun.  65: 1455-1461.
  172. Mott, J.,Y. Rikihisa, Y. Zhang, S. M. Reed, C.Y. Yu..  (1997)  Polymerase chain reaction and Southern blot analysis of E. risticii in the blood and feces of horses. J. Clin. Microbiol. 35: 2215-2219.
  173. Lee, E. and Y. Rikihisa.  (1997)  Anti-Erhlichia chaffeensis antibody induces potent proinflammatory cytokine mRNA expression in human monocytes exposed to E. chaffeensis through sustained reduction of IkB-α and activation of NF-kB.  Infect. Immun.  65: 2890-2897.
  174. Zhang, Y. and Y. Rikihisa. (1997) Tyrosine phosphorylation is required for ehrlichial internalization and replication in P388D1 cells. Infect. Immun. 65: 2959-2964.
  175. Wen, B., Y. Rikihisa, N. Zhi, R. Greene, and R. Bartsch. (1997) Nested polymerase chain reaction for detection of Ehrlichia canis infection in dogs. J. Clin. Microbiol.  35: 1852-1855.
  176. Zhi, N., Y. Rikihisa, H.Y. Kim, G.P. Wormser, and H.W. Horowitz.  (1997)  Comparison of major antigenic proteins of six strains of human granulocytic ehrlichiosis agents by Western immnoblot analysis.  J. Clin. Microbiol. 35: 2606-2611.
  177. Madigan, J.E., J.E. Barlough, Y. Rikihisa, B. Wen, P.E. Miller, and T.J. Sampson.  (1996)  Identification of the "Shasta River Crud" syndrome as Potomac horse fever (Equine monocytic ehrlichiosis).  J. Equine Vet. Sci.  17: 270-272.
  178. Wen, B., Y. Rikihisa, S. Yamamoto, and P. Fuerst.  (1996)  Characterization of SF agent, an Ehrlichia sp. isolated from Stellantchasmus falcatus fluke, by 16S rRNA base sequence, serological, and morphological analysis.  Int. J. Syst. Bacteriol.  46, 149-154.
  179. Kawahara, M., C. Suto, S. Shibata,M. Futohashi, and Y. Rikihisa. (1996) Impaired antigen specific responses and enhanced polyclonal stimulation in mice infected with Ehrlichia muris. Microbiol. Immunol. 40:575-581.
  180. Lee, E. and Y. Rikihisa.  (1996) Absence of TNF-α, IL-6, and GM-CSF but presence of IL-1β, IL-8, and IL-10 expression in human monocytes exposed to viable or killed Ehrlichia chaffeensis.  Infect. Immun. 64:4211-4219.
  181. Perez, M., Y. Rikihisa, and B. Wen. (1996) Antigenic and genetic characterization of an Ehrlichia canis-like agent isolated from a human in Venezuela. J. Clin. Microbiol. 34:2133-2139.
  182. Rikihisa, Y., Y. Zhang, and J. Park  (1995)  Role of Ca2+ and calmodulin on ehrlichial survival in macrophages.  Infect. Immun. 63, 2310-2316.
  183. Rikihisa, Y.  (1995)  Ehrlichial Diseases.  In Zoonotic Diseases.  Clin. Microbiol. 22, 413-419 (In Japanese).
  184. Wen, B., Y. Rikihisa, J. Mott, P.A. Fuerst, and M. Kawahara.  (1995) Ehrlichia muris sp. nov., a new species of Ehrlichia, identified on the basis of 16SrRNA base sequence, serological, morphological, and biological characteristics.  Int. J. Syst. Bacteriol.  45, 250-254.
  185. Pretzman, C., D. Ralph, D. Stotherd, P. Fuerst, and Y. Rikihisa.  (1995) 16SrRNA sequence relatedness of Neorickettsia helminthoeca to Ehrlichia risticii and Ehrlichia sennetsu.  Int. J. Syst. Bacteriol.  45, 207-211.
  186. Wen, B., Y. Rikihisa, P.A. Fuerst, and W. Chaichanasiriwithaya.  (1995)  Analysis of 16SrRNA genes of ehrlichial organisms isolated from horses with clinical signs of Potomac horse fever.  Int. J. Syst. Bacteriol.  45, 315-318.
  187. Madigan, J.E., Y. Rikihisa, J. Palmer, E. DeRock, and J. Mott.  (1995)  Evidence for a high rate of false positive results with the indirect fluorescent antibody test for Ehrlichia risticii antibody in horses.  Am. J. Vet. Med. Assoc.  207, 1448-1453.
  188. Yamamoto, S., S. Miyaji, K. Otabe, K. Mukawa, E. Momotani, and Y. Rikihisa.  (1994)  Preparation of anti-canine serum amyloid (SAA) serum and purification of SAA from canine high density lipoprotein.  Vet. Immunol. Immunopathol. 41, 41-53.
  189. Yamamoto, S., S. Miyaji, Y. Ashida, Y. Nishimura, H. Niizeki, and Y. Rikihisa.  (1994)  Serosurvey of anti-Ehrlichia canis antibody in dogs.  J. Japanese Small Animal Veterinary Med. Assoc. 47, 765-767. (In Japanese).
  190. Rikihisa, Y., S. Yamamoto, I. Kwak, Z. Iqbal, J. Mott, and G. Kociba.  (1994) Plasma C reactive protein and α1-acid glycoprotein concentrations in dogs infected with Ehrlichia canis.  J. Clin. Microbiol.  32, 912-917.
  191. Rikihisa, Y., S.A. Ewing, and J.C. Fox.  (1994)  Western immunoblot analysis of Ehrlichia chaffeensis, E. canis, or E. ewingii infection of dogs and human.  J. Clin. Microbiol.  32, 2107-2112.
  192. Iqbal, Z., and Y. Rikihisa.  (1994)  Reisolation of Ehrlichia canis from blood and tissues of dogs after treatment with doxycycline.  J. Clin. Microbiol.  32, 1644-1649.
  193. Messick, J.B. and Y. Rikihisa.  (1994) Inhibition of binding, entry or survival of Ehrlichia risticii in P388D1 cells by anti-E. risticii IgG and Fab fragments.  Infect. Immun.  62, 3156-3161.
  194. Iqbal, Z., W. Chaichanasiriwithaya, and Y. Rikihisa.  (1994) Comparison of PCR and Western immunoblot analysis in early diagnosis of canine ehrlichiosis.  J. Clin. Microbiol.  32, 1658-1662.
  195. Iqbal, Z. and Y. Rikihisa.  (1994)  Application of polymerase chain reaction for detection of Ehrlichia canis in tissues of dogs.  Vet. Microbiol.  42, 281-287.
  196. Barnewall, R. and Y. Rikihisa.  (1994)  Abrogation of interferon-γ induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron transferin.  Infect. Immun.  62, 4804-4810.
  197. Lin, Y.C., A. Sambuissho, S. Coskun, Y. Rikihisa.  (1994)  Inhibition of in vitro fertilization and early embryogenic development in hamsters by gossypol.  Life. Sci. 55, 1139-1145.
  198. Chaichanasiriwithaya, W., Y. Rikihisa, S. Yamamoto, S.M. Reed, L.E. Perryman, T.B. Crawford, and G. Palmer.  (1994)  Antigenic, morphologic, and molecular characterization of 9 new Ehrlichia risticii isolates.  J. Clin. Microbiol. 38, 3026-3033.
  199. Rikihisa, Y., Y. Zhang, and J. Park.  (1994)  Role of clathrin, microfilament, and microtubule on infection of mouse peritoneal macrophages with Ehrlichia risticii.  Infect. Immun.  62, 5126-5132.
  200. Yamamoto, S., T. Shida, K. Otabe, E. Furukawa, Y. Isayama, and Y. Rikihisa.  (1994)  Serum C-reactive protein and immune responses in dogs inoculated with Bordetella bronchiseptica (phase I cells).  Vet. Res. Commun. 18, 347-357.
  201. Rikihisa, Y., R. Wada, S.M. Reed, and S. Yamamoto.  (1993) Development of neutralizing antibodies in horses infected with Ehrlichia risticii.  Vet. Microbiol. 36, 139-147.
  202. Kawahara, M., C. Suto, and Y. Rikihisa.  (1993) Characterization of Ehrlichial organisms isolated from a wild mouse.  J. Clin. Microbiol.  31, 89-96.
  203. Kulp, S.K., Y. Rikihisa, Y.C. Lin, P.P. Moh, P.K. Li, and Y. Gu. (1993)  In vitro uptake and autoradiographic localization of 3H-gossypol in Taenia taeniaeformis metacestode.  Parasitol. Res.  79, 279-285.
  204. Messick, J.B. and Y. Rikihisa.  (1993)  Characterization of Ehrlichia risticii binding, internalization, and growth in host cells by flow cytometry.  Infect. Immun. 61, 3803-3810.
  205. van Heeckeren, A., Y. Rikihisa, J. Park, and R. Fertel.  (1993) Tumor necrosis factor-α, Interleukin-1β, Interleukin-6 and prostaglandin E2 production in murine peritoneal macrophages infected with Ehrlichia risticii.  Infect. Immun. 61, 4333-4337.
  206. Messick, J.B. and Y. Rikihisa.  (1992) Suppression of I-Ad on P388D1 cells by Ehrlichia risticii infection in response to gamma interferon.  Vet. Immunol. Immunopathol.  32, 225-241.
  207. Rikihisa, Y., G.J. Johnson, Y.-Z. Wang, S.M. Reed, R. Fertel, and H.J. Cooke. (1992) Loss of adsorptive capacity for sodium chloride as a cause of diarrhea in Potomac horse fever.  Res. Vet. Sci. 52, 353-362.
  208. Riond, J.-L., J.E. Riviere, W.M. Duckett, C.E. Atkins, A.D. Jernigan, Y. Rikihisa, and S.L. Spurlock.  (1992) Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses.  Equine Vet. J. 24, 41-45.
  209. Rikihisa, Y., S.A. Ewing, J.C. Fox, A.G. Siregar, F.H. Pasaribu, and M.B. Malole.  (1992) Enzyme-linked immunosorbent assay and western immunoblot analysis of E. canis and canine granulocytic Ehrlichia.  J. Clin. Microbiol.  30, 143-148.
  210. Budiarso, I.T. and Y. Rikihisa.  (1992) Pulmonary vascular lesions in Jembrana disease.  Vet. Pathol. 29, 210-215.
  211. Messick, J.B. and Y. Rikihisa.  (1992) Presence of parasite antigens on the surface of P388D1 cells infected with Ehrlichia risticii.  Infect. Immun.  60, 3079-3086.
  212. Park, J. and Y. Rikihisa.  (1992) L-arginine-dependent killing of intracellular Ehrlichia risticii by macrophages treated with interferon-gamma.  Infect. Immun.  60, 3504-3508.
  213. Chen, C.J.A., Y.C. Lin, R.W. Brueggemeier, and Y. Rikihisa.  (1992) Morphometric analysis renal cortex changes induced by diethylstilbestrol (DES) in syrian hamsters.  Research Communications in Chemical Pathology and Pharmacology.  78, 341-358.
  214. Kiper, M.L., Traub-Dargtz, J., Salman, M.D., and Y. Rikihisa. (1992)  Risk factors for equine monocytic ehrlichiosis seropositivity in horses in Colorado.  Preventive Medicine 13, 251-259.
  215. Lin, Y.C., P. Rajamahendran and Y. Rikihisa (1991) Inhibition of rat embryo implantation in the gossypol-treated uterine horn.  Theriogenology. 35, 769-777.
  216. Dawson, J.E., Y. Rikihisa, S. Ewing and D.B. Fishbein (1991) Serologic diagnosis of human ehrlichiosis using two Ehrlichia canis isolates.  J. Infect. Dis. 163, 564-567.
  217. Coskun, S., A. Sunbuissho, Y.C. Lin and Y. Rikihisa (1991) Fertilizability and subsequent developmental ability of bovine oocyte matured in medium containing epidermal growth factor (EGF).  Theriogenology.  36, 485-494.
  218. Gu, Y., P.K. Li, Y.C. Lin, Y. Rikihisa and R.W. Brueggemeier (1991) Gossypolone suppresses progesterone synthesis in cultured bovine luteal cells.  J. Steroid Biochem. Mol. Biol. 38, 709-715.
  219. Rikihisa, Y. (1991) Protection against murine Potomac horse fever by an inactivated Ehrlichia risticii vaccine. Vet. Microbiol. 28: 339-350.
  220. Rikihisa, Y., H. Stills, and G. Zimmerman.  (1991)  Isolation and continuous culture of Neorickettsia helminthoeca in a macrophage cell line.  J. Clin. Microbiol. 29, 1928-1933.
  221. Park, J. and Y. Rikihisa.  (1991) Inhibition of Ehrlichia risticii growth in murine peritoneal macrophage by gamma interferon, calcium ionophore, and concanavalin A.  Infect. Immun.  59, 3418-3423.
  222. Rikihisa, Y.  (1991)  Cross-reacting antigens between Neorickettsia helminthoeca and Ehrlichia spp. shown by immunofluorescence and Western immunoblotting.  J. Clin. Microbiol.  29, 2024-2029.
  223. Rikihisa, Y. (1991) The tribe Ehrlichieae and ehrlichial diseases.  Clin. Microbiol. Rev. 4:286-308.
  224. Lin, Y.C., Y. Gu, R.W. Brueggemeier, and Y. Rikihisa.  (1991)  Binding of 3H-gossypol in organelles in cultured bovine luteal cells.  Life Sci 50, 443-447.
  225. Lin, Y.C., M. Chitcharoenthum, Y. Rikihisa and F.C. Gwazdauska (1990) Effect of gossypol on thyroid hormones in young female rats.  Contraception 41, 431-440.
  226. Gu, Y., .G. Chang, Y. Rikihisa and Y.C. Lin (1990) Inhibitory effect of gossypol on human chorionic hormone (hCG)-induced progesterone secretion in cultured bovine luteal cells.  Life Sciences. 47, 407-414.
  227. Lin, Y.C., Y. Rikihisa, H. Kono, and Y. Gu (1990) Effect of larval tapeworm (Taenia taeniaeformis) infection on reproductive functions in male and female host rats.  Exp. Parasitol. 70, 344-352.
  228. Rikihisa, Y., Y.C. Lin, P.L. Garber, and Y. Gu (1990) Taenia taeniaeformis: Inactivation of metacestode by gossypol in vitro. Exp. Parasitol. 71, 135-145.
  229. Rikihisa, Y., S.M. Reed, R.A. Sams, J.C. Gordon and C.I. Pretzman (1990) Serosurvey of horses with evidence of equine monocytic ehrlichiosis (Potomac horse fever).  J. Am. Vet. Med. Assoc. 197, 1327-1332.
  230. Gu. Y, Y.C. Lin, and Y. Rikihisa (1990).  Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells.  Biochem. Biophys. Res. Commun. 169, 455-461.
  231. Rikihisa, Y. (1990) Growth of Ehrlichia risticii in human colonic epithelial cells.  In: Rickettsiology:  Current issues and perspectives. New York Acad. Sci. 590, 104-110. 
  232. Rikihisa, Y. and Y.C. Lin (1989) Effect of gossypol on the thyroid in young rats.  J. Comp. Pathol. 100, 411-417.
  233. Lin, Y.C., R. Rajamahendran, Y. Rikihisa and F.C. Gwazdauskas (1989) Effect of gossypol and its metabolite on in vitro early development of mouse embryos.  Theriogenology  31, 727-740.
  234. Rikihisa, Y. and B.M. Jiang (1989) Effect of antibiotics on clinical, gross pathologic, and immunologic responses of mice infected with Ehrlichia risticii; Protective effects of doxycycline.  Vet. Microbiol. 19, 253-262.
  235. August, J.R., W.R. Chickering and Y. Rikihisa (1988) Congenital ichthyosis in a dog: Comparison with the human ichthyosiform dermatoses.  Compendium of Continuing Education 10, 40-45. 
  236. Rikihisa, Y. and Y.C. Lin (1988) Ultrastructural changes in testes and epididymides of Japanese quail (Coturnix coturnix japonica) after gossypol treatment.  Poult. Sci., 67, 961-972.
  237. Lin, Y.C., T. Dietrick and Y. Rikihisa (1988) Antifertility effect of gossypol in male Japanese quail (Coturnix coturnix japonica).  Life Sci. 42, 2283-2292.
  238. Rikihisa, Y. and B.M. Jiang (1988) In vitro susceptibility of Ehrlichia risticii to eight antibiotics.  Antimicrobial Agents & Chemotherapy 32, 986-991.
  239. Wells, M.Y. and Y. Rikihisa (1988) Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells:  Abrogation of inhibition with oxytetracycline. Infect. Immun. 56, 3209-3215.
  240. Rikihisa, Y., C.I. Pretzman, G.C. Johnson, S.M. Reed, S. Yamamoto and F. Andrews (1988) Clinical and immunological responses of ponies to Ehrlichia sennetsu and subsequent Ehrlichia risticii challenge.  Infect. Immun. 56, 2960-2966.
  241. Lin, Y.C., M. Chitcharoenthum and Y. Rikihisa (1987) Effect of gossypol on spermatozoal lactate dehydrogenase‑X (LDH‑X) in male rats.  Contraception, 36, 581‑592.
  242. Lin, Y.C. and Y. Rikihisa (1987) Antiandrogenic activity of gossypol metabolites in young male rats.  In: "Cell Biology of the Testis and Epididymis."  Ann. New York Acad. Sci..  83‑85.
  243. Pretzman, C.I., Y. Rikihisa and D. Ralph (1987) Enzyme‑linked immunosorbent assay for detecting Potomac horse fever disease.  J. Clin. Microbiol. 25, 31‑36.
  244. Rikihisa, Y., G.J. Johnson and C.J. Burger (1987) Reduced immune responsiveness and lymphoid depletion in mice infected with Ehrlichia risticii.  Infect. Immun. 55, 2215‑2222.
  245. Rikihisa, Y., Y.C. Lin and A. Walton (1986) Taenia taeniaeformis: Immunoperoxidase localization of metacestode culture product(s) in hyperplastic gastric mucosa.  Exp. Parasitol. 61, 134‑137.
  246. Perry, B.D., J.E.Palmer, H.F. Troutt, J.B. Birch, D. Morris and Y. Rikihisa (1986) A case‑control study of Potomac horse fever.  Prev. Vet. Med. 4, 69‑82.
  247. Cordes, D.O., B.D. Perry, Y. Rikihisa and W.R. Chickering (1986) Enterocolitis caused by Ehrlichia sp. in the horse (Potomac horse fever).  Vet. Pathol.  23, 471‑477.
  248. Steele, K., Y. Rikihisa and A. Walton (1986) Demonstration of Ehrlichia in Potomac horse fever using a silver stain.  Vet. Pathol. 23, 531‑533.
  249. Burger, C.J., Y. Rikihisa and Y.C. Lin (1986) Taenia taeniaeformis inhibition of mitogen‑induced proliferation and interleukin 2 production in rat splenocytes by larval in vitro product.  Exp. Parasitol. 62, 216‑222.
  250. Rikihisa, Y. and Y.C. Lin (1986) Taenia taeniaeformis:  Inhibition of metacestode development in the rat by gossypol. Exp.  Parasitol. 61, 127‑133.
  251. Lin, Y.C., T. Fukaya, Y. Rikihisa and A. Walton (1985) Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats.  Life Science 37, 39‑47.
  252. Blohowiak, C.C., T.L. De Santo, Y. Rikihisa and Y.C. Lin (1985) Diurnal, premating and postmating testosterone levels in chickens genetically selected for mating frequency.  Poultry Sci. 64, 1028‑1030.
  253. August, J.R., A.S. Loar, G.K. Saunders and Y. Rikihisa (1985) Membranous glomerular nephropathy and nephrotic syndrome in a cat. Compendium of Continuing Education 7, 363‑368.
  254. Rikihisa, Y. and Y.C. Lin (1985) Taenia taeniaeformis:  Inhibit­ion of testosterone production by culture excretory‑secretory product of larvae.  Exp. Parasitol. 59, 390‑397.
  255. Rikihisa, Y. and B.D. Perry (1985) Causative ehrlichial organisms in Potomac Horse Fever.  Infect. Immun. 49, 513‑517.
  256. King, C.S., Y.C. Lin, T. Fukaya and Y. Rikihisa (1985) In vivo and in vitro inhibition of HCG‑induced testosterone production in rat testes by bursa of fabricius extract.  Poultry Sci. 64, 1223‑1226.
  257. Lin, Y.C., T. Fukaya, Y. Rikihisa and T. DeSanto (1985) Inhibitory effect of gossypol on human chorionic   gonadotropin induced testos­terone secretion in young male rats.  Adv. Contraceptive Deliv. Syst. 200‑207.
  258. Rikihisa, Y. (1985) Ultrastructural localization of carbonic anhydrase in lysosomes.  Anat. Rec. 211, 1‑8.
  259. Rikihisa, Y., B.D. Perry and D.O. Cordes (1985) Ultrastructural study of rickettsial organisms in the large colon of ponies exper­imentally infected with Potomac Horse Fever.  Infect. Immun. 49, 505‑512.
  260. Lin, Y.C., T. Fukaya and Y. Rikihisa (1985) Age related human chorionic gonadotropin responsiveness for testosterone production in young male rats.  Life Science 37, 481‑488.
  261. Rikihisa, Y., Y.C. Lin and A. Walton (1985) Histopathologic changes of uterus in gossypol‑treated early‑pregnant rat.  Anat. Rec. 213, 72‑76.
  262. Perry, B.D., Y. Rikihisa and G. Saunders (1985) Transmission of Potomac Horse Fever by intradermal route.  Vet. Rec. 116, 246‑247.
  263. Hammerberg, C., M. Hollingshead, Y. Rikihisa and R.DeBuysscher (1985) Porcine lymphoblastoid cell lines of B‑cell origin.  Vet. Immunol. Immunopathol. 10, 367‑380.
  264. Rikihisa, Y. (1984) Glycogen autophagosomes in polymorphonuclear leukocytes induced by rickettsiae.  Anat. Rec. 208, 319‑327.
  265. Rikihisa, Y. and Y.C. Lin (1984) Taenia taeniaeformis: Increased cell growth and neutral mucus production in the gastric mucosa of the rat infected with the larvae.  Exp. Parasitol. 58, 147‑155.
  266. Rikihisa, Y., T. Letonja, N. Pratt and Y.C. Lin (1984) Taenia taeniaeformis: Characterization of larval metabolic product and growth of host gastric cells in vitro.  Exp. Parasitol. 58, 230‑238.
  267. Hammerberg, B., Y. Rikihisa and M.W. King (1984) Immunoglobulin interactions with surfaces of sheathed and unsheathed microfilariae.  Parasite Immunol. 6, 421‑434.
  268. Rikihisa, Y., B.D. Perry and D. Cordes (1984) Rickettsial link with acute equine diarrhea.  Vet. Rec. 115, 390.
  269. Rikihisa, Y. and B.D. Perry (1984) Causative agent of Potomac Horse Fever.  Vet. Rec. 115, 554.
  270. Letonja, T., Rikihisa, Y. and C. Hammerberg (1984) Differential cellular response of resistant and susceptible rodents to the early stage of infection of Taenia taeniaeformis.  Intl. J. Parasitol. 14, 551‑558.
  271. Rikihisa, Y. and S. Ito (1983) Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes. Infect. Immun. 39, 928‑938.
  272. Rikihisa, Y. and S. Ito (1982) Mechanism of entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.  Infect. Immun. 38, 343‑350.
  273. Rikihisa, Y. and S. Ito (1980) Localization of electron dense tracers during entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.  Infect. Immun. 30, 231‑242.
  274. Onitsuka, M., Y. Rikihisa and H.B. Maruyama (1979) Biochemical and topological studies on Escherichia coli cell surface IV. Giant spheroplast formation from filamentous cell.  J. Bacteriol. 138, 567‑574.
  275. Rikihisa, Y., T.R. Rota, A.B. MacDonald and S. Ito (1979) Changes in immunoferritin labeling of Rickettsia tsutsugamushi after serial cultivation in 60Co‑irradiated BHK cells.  Infect. Immun. 26, 638‑650.
  276. Rikihisa, Y. and S. Ito (1979) Intracellular localization of R. tsutsugamushi in polymorphonuclear leukocytes.  J. Exp. Med. 150, 703‑708.
  277. Rikihisa, Y. and D. Mizuno (1978) Different perturbations of phagolysosome membranes depending on the particles phagocytized: Observations with markers of the two sides of plasma membrane.  Exp. Cell Res. 111, 437‑449.
  278. Rikihisa, Y. and D. Mizuno (1977) Demonstration of myosin on the cytoplasmic side of plasma membrane of guinea pig polymorphonuclear leukocytes.  Exp. Cell Res. 110, 87‑92.
  279. Rikihisa, Y. and D. Mizuno (1977) Binding of markers of either side of plasma membranes to the cytoplasmic side of paraffin oil‑loaded phagolysosomes.  Exp. Cell Res. 110, 93‑102.
  280. Rikihisa, Y. and D. Mizuno (1977) Binding of markers of either side of plasma membranes to the cytoplasmic side of lysosomes. Exp. Cell Res. 110, 103‑110.
  281. Rikihisa, Y., S. Ohkuma and D. Mizuno (1976) Improved imunoferritin technique to remove nonspecific binding.  Cell Structure and Function 1, 251‑258.
  282. Rikihisa, Y., S. Ohkuma and D. Mizuno (1976) Antigenic difference between the outer and inner surfaces of plasma membranes of polymorphonuclear leukocytes shown with imunoferritin. Exp. Cell Res. 100, 23‑30.

Book Chapters (27)

  1. Rikihisa, Y. (2017) The family Anaplasmataceae. In: Pathogenic bacteria, Virus. Ed. Hiroshi Oda,  Hokkaido University press. (In Japanese). In press.
  2. Thomas, S., W. Alexander, J. Gilligan, and Y. Rikihisa. (2016) Importance of Rickettsiales infections. In: Rickettsiales. Biology, Molecular Biology, Epidemiology, and Vaccine Development. Ed. Sunil Thomas.  Springer International Publishing AG Switzerland. PP.3-22.
  3. Niu, H. and Y. Rikihisa. (2016) Chapter 8. Intracellular Bacterium Anaplasma phagocytophilum  Induces Autophagy by Secreting Substrate Ats-1 that neutralizes the Beclin 1-ATG14L Autophagy  Initiation Pathway.  In: AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Ed. M. A. Hayat. Elsevier Publishing Company volume 9 Human Diseases and Autophagosome: PP 308-314.
  4. Rikihisa, Y. (2015) Salmon poisoning disease and Elokomin fluke fever. In: Merck Veterinary Manual. Veterinary professionals, Generalized Conditions, Rickettsial Diseases. [ rickettsial_diseases/salmon_poisoning_disease_and_elokomin_fluke_fever.html]
  5. Rikihisa, Y. (2009) Ehrlichia, Anaplasma. In: Intracellular Niches of Pathogens—A microbe’s Guide through the host cell. Ed. Ulrich E. Schaible and Albert Haas. Wiley-VCH Publishers. pp. 301-314.
  6. Hechemy, K.E. and Y. Rikihisa (2007) Rickettsiology: Present and Future. In: Contemporary State of The Rickettsioses in the World and in Bulgaria. Ed. By Emil Alexandrov. pp. 17-26.
  7. Hechemy, K.E. Y. Rikihisa, K. Macaluso, A. W. O. Burgess, B. E. Anderson, and H. A. Thompson. (2006) The Rickettsiaceae, Anaplasmataceae, Bartonellaceae, and Coxiellaceae. In 7th ed. Manual of Clinical Laboratory Immunology.  American Society for Microbiology Press, Washington, D.C. pp. 526-539.
  8. Dumler, J.S., Y. Rikihisa, and G.A. Dasch. Anaplasmataceae. In Brenner, Krieg, Staley and Garrity  (Editors), The Proteobacteria, Part C, Bergey's Manual of Systematic Bacteriology, 2nd. Ed., Vol. 2, Springer,  New York, NY (2005), p. 117.
  9. Dumler, J.S., Y. Rikihisa,  and G.A. Dasch. Anaplasma. In Brenner, Krieg, Staley and Garrity  (Editors), The Proteobacteria, Part C, Bergey's Manual of Systematic Bacteriology, 2nd. Ed., Vol. 2, Springer,  New York, NY (2005), pp. 117-125.
  10. Dumler, J.S., Y. Rikihisa,  and G.A. Dasch. Ehrlicihia. In Brenner, Krieg, Staley and Garrity  (Editors), The Proteobacteria, Part C, Bergey's Manual of Systematic Bacteriology, 2nd. Ed., Vol. 2, Springer,  New York, NY (2005), pp. 125-131
  11. Rikihisa, Y. J.S. Dumler and G.A. Dasch. Neorickettsia. In Brenner, Krieg, Staley and Garrity  (Editors), The Proteobacteria, Part C, Bergey's Manual of Systematic Bacteriology, 2nd. Ed., Vol. 2, Springer,  New York, NY (2005), pp. 132-137
  12. Rikihisa, Y. and J.P. Kreier. Aegyptianella. In Brenner, Krieg, Staley and Garrity  (Editors), The Proteobacteria, Part C, Bergey's Manual of Systematic Bacteriology, 2nd. Ed., Vol. 2, Springer,  New York, NY (2005), pp. 143-145.
  13. Rikihisa, Y.  (2004)  Rickettsial diseases.  In: Equine Internal Medicine.  2nd Edition. Ed. by S.M. Reed,W. Bayly and D.C. Sellon eds. W.B. Saunders. PP. 96-109.
  14. Waites, K. B., Y. Rikihisa, and D. Taylor-Robinson (2003) Mycoplasma and Ureaplasma. .In  Manual of Clinical Microbiology, 8th Edition. Ed., by P.A. Murray. American Society for Microbiology, Washington, D.C.  PP. 972-990
  15. Hechemy, K.E. and Y. Rikihisa. (2002) Immunoserology of Rickettsiales, Bartonella, and Coxiella. In 6th ed. Manual of Clinical Laboratory Immunology.  Ed., by N.R. Rose, R.G. Hamilton, B. Detrick. ASM Press, Wasington, D.C. pp.528-541.
  16. Rikihisa, Y.  (2000) Ehrlichial strategy for survival and proliferation in the leukocytes. In: Subcellular Biochemistry: Bacterial invasion into eukaryotic cells. eds. J. Hacker and T. Olschlger. Plenum Publishing Co. 33: 517-538.
  17. Rikihisa, Y.  (2000) Analysis of pathogenesis of human ehrlichiosis, In: Eds. By  T. Kurata and F. Amano. Latent Pathogen, 5:  Saikon publishing  Co., Tokyo (In Japanese). PP. 197-212.
  18. Rikihisa, Y.  (1999)  Ehrlichiae of Veterinary Importance.  In: Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium. Eds. by D. Raoult and P. Brouqui.  Elsevior,  Paris. 393-405.
  19. Rikihisa, Y.  (1997)  Rickettsial diseases in horses.  In Equine Internal Medicine.  Ed. by W. Bayly and S.M. Reed.  eds. W.B. Saunders.  112-123.
  20. Rikihisa, Y.  (1996)  Ehrlichiae.  In:  Rickettsiae and Rickettsial Diseases (Bratislava, Slovak Republic).  Slovak Academy of Sciences, Bratislava, Slovak Republic:  International Society of Rickettsiae and Rickettsial Diseases, pp 272-286.
  21. Rikihisa, Y. and G. Zimmerman.  (1995)  Salmon poisoning disease.  In  Current Veterinary Therapy XII  Small Animal Practice  Ed. by Kirk and Bonagura.  P. 297-300.  W.B. Saunders Co., Philadelphia.
  22. Rikihisa, Y.  (1995)  Chapter 1.  Classification and Morphology of Bacteria and Fungi.  InEssentials of Veterinary Bacteriology, Mycology, and Virology by G.R. Carter, Lee and Febiger, Philadelphia, P. 3-15.
  23. Rikihisa, Y. (1990) Ultrastructure of rickettsiae with special emphasis on ehrlichia. In: Ehrlichiosis:  A vector-borne Disease of Animals and Humans. In Current Topics in Veterinary Medicine and Animal Sciences, 54, p. 22-31.  Ed. by J.C. Williams and I. Kakoma, Kluwer Publishing Co., Norwell, MA.
  24. Rikihisa, Y. (1986) Chapter 1. Classification and Morphology of bacteria and fungi. In: Essentials of Veterinary Bacteriology and Mycology by G.R. Carter, Lea and Febiger, Philadelphia, pp 3‑15.
  25. Rikihisa, Y. (1986) Ultrastructural studies of ehrlichial organisms in the organs of ponies with equine monocytic ehrlichiosis (synonym, Potomac horse fever).  In H. Winkler and M. Ristic eds.  Microbiology 1986 American Society for Microbiology, Washington, D.C.,  pp. 200‑202.
  26. Rikihisa, Y. and S. Ito (1981) Outer membrane vesicles of Rickettsia tsutsugamushi in baby hamster kidney cells.  In: Rickettsiae and Rickettsial Diseases.  Eds. Willy Burgdorfer and Robert L. Anacker.  Academic Press, pp. 229‑240.
  27. Ito, S. and Y. Rikihisa (1981) Techniques for electron microscopy of rickettsiae. In: Rickettsiae and Rickettsial Diseases.  Eds. Willy Burgdorfer and Robert L. Anacker.  Academic Press, pp.  213‑227.