Yasuko Rikihisa, PhD
Distinguished University Professor
Member, National Academy of Sciences
Professional Training and Experience
- PhD, MS, University of Tokyo
- Postdoctoral Fellow, Harvard Medical School
- Understanding the molecular pathogenic mechanisms of ehrlichiosis/anaplasmosis, vector-borne emerging infectious diseases of man (zoonosis) and animals.
- Elucidation of Ligand and Receptor, and Invasion Mechanisms of Intracellular Bacteria.
- Determination of Nutritional Virulence of Intracellular Bacteria-Hijacking Autophagy Pathway by Bacterial Molecules Secreted by Type IV Secretion System.
- Analysis of Regulation of Intracellular Growth and Development by Bacterial Two-component Regulatory System.
- Investigation of Ehrlichia strain-variable Disease Pathogenesis In vivo Virulence Linked to Comparative Genome Sequence and Transcriptome Analysis
- Isolation, and Molecular and Antigenic Characterization of New Ehrlichia, Anaplasma, and Neorickettsia spp., Aegyptianella and Haemotropic Mycoplasma.
- Test Disease Intervention Strategy by using Animal models of Potomac horse fever, canine ehrlichiosis, human monocytic ehrilichiosis, and human granulocytic anaplasmosis.
- Development of Vaccines and Diagnostic Procedures: PCR, dot blot, Western blot, IFA, ELISA, culture isolation, cloning protective and diagnostic antigens.
- Analysis of Molecular Mechanisms of Vector (tick, trematode) transmission, and determination of Natural Reservoirs.