Skip to main content
Yasuko Rikihisa, PhD
Distinguished University Professor
Member, National Academy of Sciences

Department of Veterinary Biosciences

The Ohio State University
1925 Coffey Rd.
Columbus, Ohio 43210

(614) 292-9677
(614) 292-6473

Professional Training and Experience

  • PhD, MS, University of Tokyo
  • Postdoctoral Fellow, Harvard Medical School

Research Interests

The Rikihisa Laboratory

  • Understanding the molecular pathogenic mechanisms of ehrlichiosis/anaplasmosis, vector-borne emerging infectious diseases of man (zoonosis) and animals. 
  • Elucidation of Ligand and Receptor, and Invasion Mechanisms of Intracellular Bacteria.
  • Determination of Nutritional Virulence of Intracellular Bacteria-Hijacking Autophagy Pathway by Bacterial Molecules Secreted by Type IV Secretion System.
  • Analysis of Regulation of Intracellular Growth and Development by Bacterial Two-component Regulatory System.
  • Investigation of Ehrlichia strain-variable Disease Pathogenesis In vivo Virulence Linked to Comparative Genome Sequence and Transcriptome Analysis
  • Isolation, and Molecular and Antigenic Characterization of New Ehrlichia, Anaplasma, and Neorickettsia spp., Aegyptianella and Haemotropic Mycoplasma.
  • Test Disease Intervention Strategy by using Animal models of Potomac horse fever, canine ehrlichiosis, human monocytic ehrilichiosis, and human granulocytic anaplasmosis.
  • Development of Vaccines and Diagnostic Procedures: PCR, dot blot, Western blot, IFA, ELISA, culture isolation, cloning protective and diagnostic antigens. 
  • Analysis of Molecular Mechanisms of Vector (tick, trematode) transmission, and determination of Natural Reservoirs.