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Vitamin D metabolites, parathyroid hormone and fibroblast growth factor-23 – Klotho Axis in dogs with various stages of chronic kidney disease
The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.
First your dog will have a physical examination and blood pressure measurement. Then your dog will have blood and urine collected to evaluate a complete blood count (CBC), serum biochemistry profile, ionized calcium, urinalysis, urine protein: creatinine (UPC) ratio and urine culture. A small amount of blood will be stored for later evaluation of your dog’s vitamin D status and other hormones that are known to play a role in the development of RHPT. Your dog will only need to have blood and urine collected at one time and the total amount of blood collected is considered very safe for dogs. In some animals, venipuncture may result in bruising or hematoma formation at the site of blood collection. In rare cases, cystocentesis may result in hematuria or infrequently bladder rupture.
- The study will cover the costs of a CBC, biochemistry profile, ionized calcium, urinalysis, UPC, urine culture and blood pressure, vitamin D metabolite and hormone concentrations.
- Owners are responsible for all other costs.