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Publications

Selected publications (from a total of 105):

1. Mijia Lu, Piyush Dravid, Yuexiu Zhang, Sheetal Trivedi, Anzhong Li, Olivia Harder, Mahesh KC, Supranee Chaiwatpongsakorn, Ashley Zani, Adam Kenney, Cong Zeng, Chuanxi Cai, Chengjin Ye, Xueya Liang, Masako Shimamura, Shan-Lu Liu, Asuncion Mejias, Octavio Ramilo, Prosper N Boyaka, Jianming Qiu, Luis Martinez-Sobrido, Jacob Yount, Mark Peeples, Amit Kapoor, Stefan Niewiesk, Jianrong Li*. A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike. Proc Natl Acad Sci USA. 2021 118 (12) e2026153118. https://doi.org/10.1073/pnas.2026153118

 

Featured by NIH/NIAID Research Matters: https://www.nih.gov/news-events/nih-research-matters/measles-vaccine-used-base-experimental-covid-vaccine

Featured by Ohio State News: https://news.osu.edu/capitalizing-on-measles-vaccines-successful-history-to-protect-against-sars-cov-2/

Featured by Columbus Dispatch https://www.dispatch.com/story/news/2020/12/14/ohio-state-developes-covid-19-vaccine-technology/6498174002/  

 https://vet.osu.edu/about-us/news/ohio-state-innovation-foundation-exclusively-licenses-covid-19-vaccine-technology

The Vaccine Technology Has Been Licensed to Biological E. Limited, India.  

https://www.youtube.com/watch?v=y7Qb1t5YDbo

 

2. Kim E, Attia Z, Woodfint RM, Zeng C, Kim SH, Steiner HE, Shukla RK, Liyanage NPM, Ghimire S, Jianrong Li, Renukaradhya GJ, Satoskar AR, Amer AO, Liu SL, Cormet-Boyaka E, Boyaka PN. Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Proc Natl Acad Sci USA. 2021, 24;118(34):e2102435118. doi: 10.1073/pnas.2102435118.

3. Lu M, Zhang Y, Dravid P, Li A, Zeng C, K C M, Trivedi S, Sharma H, Chaiwatpongsakorn S, Zani A, Kenney A, Cai C, Ye C, Liang X, Qiu J, Martinez-Sobrido L, Yount JS, Boyaka PN, Liu SL, Peeples ME, Kapoor A, Jianrong Li*. A methyltransferase-defective VSV-based SARS-CoV-2 vaccine candidate provides complete protection against SARS-CoV-2 infection in hamsters. Journal of Virology, 2021, JVI0059221. doi: 10.1128/JVI.00592-21. 

4. Hideki Terajima, Mijia Lu, Linda Zhang, Qi Cui, Yanhong Shi, Jianrong Li and Chuan He. N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses. RNA Biology, 2021, 19(7):e3001292. doi: 10.1371/journal.pbio.3001292. 

5. Mijia Lu, Zijie Zhang, Miaoge Xue, Boxuan Zhao, Olivia Harder, Anzhong Li, Xueya Liang, Thomas Z. Gao, Yunsheng Xu, Jiyong Zhou, Zongdi Feng, Stefan Niewiesk, Mark E. Peeples, Chuan HeJianrong Li*. N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. 

Nature Microbiology, 2020 Feb 3. doi: 10.1038/s41564-019-0653-9. 

 

Highlighted by OSU News: https://news.osu.edu/exposing-a-viruss-hiding-place-reveals-new-potential-vaccine/

Comment by Dr. Volker Thiel "Viral RNA in an m6A disguise" in Nature Microbiology, 2020. https://www.nature.com/articles/s41564-020-0689-x

6. Miaoge Xue, Boxuan Zhao, Mijia Lu, Zhike Lu, Yuanmei Ma, Olivia Harder, Yunsheng Xu, Anzhong Li, Xueya Liang, Yang Yu, Ryan Jennings, Jiyong Zhou, Stefan Niewiesk, Mark E. Peeples, Chuan He, Jianrong Li*. Viral N6-methyladenosine promotes replication of human respiratory syncytial virus by enhancing nucleocapsid-mediated RNA encapsidation. Nature Communications, 2019, 10(1):4595. doi: 10.1038/s41467-019-12504-y.

Featured by OSU News: https://news.osu.edu/vaccine-against-rsv-could-be-in-sight-researchers-say/ 

7. Anzhong Li, Jingyou Yu, Mijia Lu, Yuanmei Ma, Zayed Attia, Chao Shan, Kelsey Craig, Nirajkumar Makadiya, Jingyang He, Xueya Liang, Miaoge Xue, Ryan Jennings, Pei-Yong Shi, Mark E Peeples, Shan-Lu Liu, Prosper N Boyaka, Jianrong Li*. A novel Zika virus vaccine expressing pre-membrane, envelope, and NS1 proteins. Nature Communications. 2018, 9: 3067.  

 

Featured by OSU news: https://news.osu.edu/novel-vaccine-approach-proves-powerful-against-zika-virus/

8. Yuanmei Ma, Yu Zhang, Xueya Liang, Fangfei Lou, Michael Oglesbee, Steven Krakowka, Jianrong Li*. Origin, evolution, and virulence of porcine deltacoronaviruses in the United States. mBio. 2015 mBio 6(2):e00064-15. doi:10.1128/mBio.00064-15.

9. Mike C Wolf , Alexander N FreibergTinghu ZhangZeynep Akyol-AtamanAndrew GrockPatrick W HongJianrong LiNatalya F WatsonAngela Q FangHector C AguilarMatteo PorottoAnna N HonkoRobert DamoiseauxJohn P MillerSara E WoodsonSteven ChantasirivisalVanessa FontanesOscar A NegretePaul KrogstadAsim DasguptaAnne MosconaLisa E HensleySean P WhelanKym F FaullMichael R HolbrookMichael E JungBenhur LeeA broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci USA. 2010, 107(7):3157-62.

 

10. Jianrong Li, Jennifer Wang, Sean P. J. Whelan. A unique strategy for mRNA cap methylation used by vesicular stomatitis virus. Proc Natl Acad Sci USA. 2006, 103(22): 8493-8498.

 

Other publications:

1. Mijia Lu, Miaoge Xue, Hai-Tao Wang, Elizabeth L. Kairis, Sadeem Ahmad,  Jiangbo Wei, Zijie Zhang, Yuexiu Zhang, Youling Gao, Dominique Garcin, Mark E. Peeples, Amit Sharma, Sun Hur, Chuan He, Jianrong Li*. Non-segmented negative-sense RNA viruses utilize N6-methyladenosine (m6A) as a common strategy to evade host innate immunity. Journal of Virology, 2021 Feb 3; JVI.01939-20. doi: 10.1128/JVI.01939-20.

 

2. Yunjian Lu, Hui Cai, Mijia Lu, Yuanmei Ma, Anzhong Li, Youling Gao, Jiyong Zhou, Jianrong Li*, and Jinyan Gu*. Porcine epidemic diarrhea virus deficient in RNA cap guanine-N-7 methylation is attenuated and induces higher type I and III interferon responses.  Journal of Virology, 2020, 94 (16) 94(16):e00447-20. doi: 10.1128/JVI.00447-20. (*co-corresponding author)

 Editor’s choice: This paper was selected as “spotlight” in Journal of Virology

3. Miaoge Xue, Rongzhang Wang, Olivia Harder, Phylip Chen, Mijia Lu, Hui Cai, Anzhong Li, Xueya Liang, Ryan Jennings, Krista La Perle, Stefan Niewiesk,  Mark Peeples, and Jianrong Li*.  Stable attenuation of human respiratory syncytial virus for live vaccines by deletion and insertion of amino acids in the hinge region between the mRNA capping and methyltransferase domains of the large polymerase protein. Journal of Virology, 2020, JVI.01831-20. doi: 10.1128/JVI.01831-20

4. Jenkins T, Wang R, Harder O, Xue M, Chen P, Corry J, Walker C, Teng M, Mejias A, Ramilo O, Niewiesk S, Jianrong Li, Peeples ME.  A novel live attenuated RSV vaccine candidate with mutations in the L protein SAM binding site and the G protein cleavage site is protective in cotton rats and a rhesus macaque. Journal of Virology. 2020, JVI.01568-20. doi: 10.1128/JVI.01568-20. 

5. Ross C. Larue, Enming Xing, Adam D. Kenney, Yuexiu Zhang, Jasmine A. Tuazon, Jianrong Li, Jacob S. Yount, Pui-Kai Li, Amit Sharma. Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. Bioconjugate Chem, 2021, 20;32(1):215-223. doi: 10.1021/acs.bioconjchem.0c00664.

6. Anzhong Li, Miaoge Xue, Zayed Attia, Jingyou Yu, Mijia Lu, Chao Shan, Xueya Liang, Thomas Gao, Pei-Yong Shi, Mark E Peeples, Prosper Boyaka, Shan-Lu Liu, Jianrong Li*. Vesicular stomatitis virus and DNA vaccines expressing Zika virus nonstructural protein 1 (NS1) induce substantial but not sterilizing protection against Zika virus infection. Journal of Virology, 2020, 94(17):e00048-20. 

7. Temet M. McMichael, Yu Zhang, Adam D. Kenney, Lizhi Zhang, Mijia Lu, Mahesh Chemudupati, Jianrong Li, and Jacob S. Yount. Opposing roles of endosomal innate immunity proteins IFITM3 and TLR7 in human metapneumovirus infection. Journal of Infectious Diseases, 2018, 2018, doi: 10.1093/infdis/jiy361. PMID: 29917090

8. Hui Cai, Yu Zhang, Mijia Lu, Xueya Liang, Ryan Jennings, Stefan Niewiesk, Jianrong Li*. "Phosphorylation of human metapneumovirus M2-1 protein upregulates viral replication and pathogenesis". Journal of Virology, 2016, 90(16):7323-7338.

9. Chang Liu, Yuanmei Ma, Yang Yang, Yuan Zheng, Yusen Zhou, Shibo Jiang, Lanying Du, Jianrong Li*, Fang Li*. "Entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases." Journal of Biological Sciences. 2016, 291(47): 24779-24786.

10. Elbashir Araud, Erin DiCaprio, Yuanmei Ma, Fangfei Lou, Yu Gao, David Kingsley, John Hughes, Jianrong Li*. "Thermal inactivation of enteric viruses and bioaccumulation of enteric foodborne viruses in live oysters (Crassostrea virginica)". Applied Environmental Microbiology. Vol. 82, no. 7: 2086-2099. 2016.

Editor’s choice: This paper was selected as "spotlight" in AEM.

11. Hui Cai, Yu Zhang, Yuanmei Ma, Jing Sun, Xueya Liang, Jianrong Li*. Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo. Journal of Virology, 2015 Jun 15;89(12):6391-405. doi: 10.1128/JVI.03488-14. Epub 2015 Apr 8.

12. Chang Liu #, Jian Tang #, Yuanmei Ma #, Xueya Liang, Yang Yang, Qianqian Qi, Guiqing Peng, Shibo Jiang, Jianrong Li , Lanying Du, Fang Li. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus. Journal of Virology, 2015 Mar 18. pii: JVI.00430-15. # denotes equal contribution. 

13. Erin DiCaprio E, Douglas Culbertson, Jianrong Li*. Evidence of the internalization of animal caliciviruses via the root of growing strawberry plants and dissemination to the fruit. Applied Environmental Microbiology. 2015 Feb 6. pii: AEM.03867-14.

Editors’ choice: This paper was selected as “spotlight” in AEM.

14. Yu Zhang, Stefan Niewiesk, Jianrong Li*. Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral messenger RNA cap methyltransferase. Journal of Virology, 2014, 88(19):11411-29. 

15. Jing Sun, Yongwei Wei, Abdul Rauf, Yu Zhang, Yuanmei Ma, Xiaodong Zhang, Konstantin Shilo, Qingzhong Yu, Y. M. Saif, Xingmeng Lu, Lian Yu, Jianrong Li*. Methyltransferase-defective avian metapneumovirus vaccines provide complete protection against challenge with homologous Colorado strain and heterologous Minnesota strain. Journal of Virology, 2014, 88(21):12348-63.

16. Yongwei Wei, Yu Zhang, Hui Cai, Anne Mirza, Iorio RM, Peeples ME, Niewiesk S, Jianrong Li*. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (F) protein in cell-cell fusion, viral infectivity, and pathogenesis. Journal of Virology, 2014, 88(8):4338-52.

17. Yuanmei Ma, Yongwei Wei, Xiaodong Zhang, Yu Zhang, Hui Cai, Yang Zhu, Konstantin Shilo, Michael Oglesbee, Steven Krakowka, Sean P. J. Whelan, Jianrong Li*. Messenger RNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo. Journal of Virology, 2014, 88(5):2913-26.

18. Yuanmei Ma, Yue Duan, Yongwei Wei, Xueya Liang, Stefan Niewiesk, Michael Oglesbee, Jianrong Li*. Heat shock protein 70 (HSP70) enhances mucosal immunity against human norovirus when co-expressed from a vesicular stomatitis viral vector. Journal of Virology, 2014, 88(9):5122-37.

19. Yongwei Wei, Kurtis Feng, Xiangjie Yao, Hui Cai, Junan Li, Anne Mirza, Ronald Iorio, Jianrong Li.* Localization of a region in the fusion (F) protein of avian metapneumovirus that modulates cell-cell fusion. Journal of Virology, 2012, 86(21):11800-11814. 

20. Yuanmei Ma, Jianrong Li*. Vesicular stomatitis virus as a vector to deliver human norovirus virus-like particles: a new vaccine candidate against an important non-cultivable virus. Journal of Virology, 2011,85(6): 2942-2952.

21. Jianrong Li, Errin C. Fontaine-Rodriguez, Sean P. J. Whelan. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. Journal of Virology, 2005, 79(21):13373-13384.

Editors’ choice: this paper was selected for a spotlight in Journal of Virology