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Selected Publications


  1. Varikuti, S., Natarajan G., Oghumu S., Sperling R.H., Moretti E., Stock J., Papenfuss T.L., Satoskar A.R.  2016.  Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis. Cellular Immunology. 2016  Sep 6 [Epub ahead of print]
  2. Adin C.A., VanGundy Z.C., Papenfuss TL, Xu F., Ghanem M., Lakey J., Hadley G.A.. Physiologic doses of bilirubin contribute to tolerance of islet transplants by suppressing the innate immune response. Cell Transplant. 2016 Jul 7. [Epub ahead  of print]
  3. Rosas, L.E.; Elgamal O.A.; Mo X.; Phelps M.A.; Schmittgen T.D.; Papenfuss, T.L. In vitro Immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes.  J. Immunotoxicology 2016, 13(5): 652-665
  4. Friedenberg S.G.; Strange H.R.; Guillaumin J.; VanGundy A.C.; Crouser E.D.; and Papenfuss T.L.  Effect of disrupted mitochondria as a source of damage-associated molecular patterns on the production of tumor necrosis factor α by splenocytes from dogs. American J. Veterinary Research. 2016,  77(6):604-12.
  5. Collier M.J.; Peine K.J.; Gautam S.; Oghumu S,; Varikuti S,; Borteh H,; Papenfuss T.L.; Satoskar A.R.; Bachelder E.M., Ainslie K.M.  Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.  International Journal of Pharmacology 2016, 499(1-2), 186-194.
  6. Julian M.S.; Strange H.R., Ballinger, M.N., Hotchkiss R.S., Papenfuss, T.L.; Crouser E.D.  Tolerance and cross-tolerance following Toll-like receptor (TLR)-4 and -9 activation are mediated by IRAK-M and modulated by IL-7 in murine splenocytes.  PLoS One 2015, 10(7), e0132921
  7. Peine K.J.; Guerau-de-Arellano M.; Lee P.; Kanthamneni N.; Severin M.; Probst G.D.; Peng H.; Yang Y.; VanGundy Z.; Papenfuss T.L.; Lovett-Racke A.E.; Bachelder E.M.; Ainslie K.M.  Treatment of experimental autoimmune encephalomyelitis by co-delivery of disease associated peptide and dexamethasone in acetalated dextran microparticles. Molecular Pharmaceutics  2014,11(3), 828-835.
  8. VanGundy Z.; Baker J.D.; Taylor C.L.; White A.M.; Muth D.; Papenfuss T.L. Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells. BMC Immunology 2014, 15(1), 8.
  9. VanGundy Z.C.; Markowitz J.; Baker J.D.; Strange H.R.; Papenfuss T.L. In vitro model system to generate breast cancer MDSCs and study immune cell interactions in immunocompetent C57Bl/6 mice.  J Cancer Biol Res  2014, 2(1), 1017.
  10. Julian M.W.; Shao G.; VanGundy Z.C.; Papenfuss T.L.; Crouser E.D. Mitochondrial transcription factor A (TFAM), a danger signal released from damaged cells, promotes TNF-alpha release via RAGE and TLR9-responsive plasmacytoid dendritic cells. PloS One 2013, 8(8), 372354.
  11. Manickam C.; Dwivedi V.; Miller J.; Papenfuss T.; Renukaradhya G.J. Mycobacterium tuberculosis Whole Cell Lysate Enhances Proliferation of CD8 Positive Lymphocytes and Nitric Oxide Secretion in the Lungs of Live Porcine Respiratory and Reproductive Syndrome Virus Vaccinated Pigs. Viral Immunology 2013, 26(1), 102-108.
  12. Manickam C.; Dwivedi V.; Patterson R.; Papenfuss T.; Renukaradhya G.J. Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pig. Veterinary Microbiology 2013, 162(1), 68-77.
  13. Markowitz J.; Wesolowski R.; Papenfuss T.; Brooks TR.; Carson W.E. 3rd  Myeloid Derived Suppressor Cells in Breast Cancer.  Breast Cancer Res & Treatment. 2013, 140(1), 13-21.
  14. Oghumu S.; Gupta G.; Snider H.M.; Varikuti S.; Terraza C.A.; Papenfuss T.L.; Kaplan M.H.; Satoskar A.R.  STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmanisasis.  EurJ Immun  2013, 44(2), 450-459.
  15. Peine K.J.; Bachelder E.M.; Vangundy Z.; Papenfuss, T.L.; Brackman D.J.; Gallovi M.D.; Schully K.; Pesce J.; Keane-Myers A.; Ainslie, K.M.  Efficient Delivery of the TLR-Agonists Poly I:C and CpG to Macrophages by Acetalated Dextran Microparticles Molecular Pharmaceutics  2013,  10(8), 2849-2857.
  16. Peine K.J.; Gupta G.; Brackman D.J.; Papenfuss, T.L.; Ainslie K.M.; Satoskar A.R.; Bachelder E.M. Liposomal resiquimod for the treatment of Leishmania donovani infection.  J. Anitmicrob Chemother 2013, 69(1), 168-175.
  17. Julian M.W.; Shao G.; Bao S.; Knoell D.L.; Papenfuss, T.L.; Crouser E.D. Mitochondrial transcription factor A (TFAM) serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA. Journal of Immunology 2012, 189(1), 433-443.
  18. Park J.; Kogure T.; Nuovo G.J.; Jian J.; He L.; Kim J.H.; Phelps M.A.; Papenfuss, T.L.; Croce C.M.; Patel T.; Schmittgen T.D. Silencing of miR-221 with anti-microRNA oligonucleotides is an effective therapy for hepatocellular carcinoma. Cancer Research 2012, 71(24), 7608-7616.
  19. Peng H.; Guerau-de-Arellano M.; Mehta V.B.; Yang Y.; Huss D.J.; Papenfuss, T.L.; Lovett-Racke A.E.; Racke M.K. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. Journal of Biological Chemistry 2012, 287(33), 28017-26.
  20. Sherger M.; Kisseberth W.; London C.; Olivo-Marston S.; Papenfuss, T.L. Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs. BMC Vet Res 2012, 8(1), 209.
  21. Wasserman J.; Diese L.; VanGundy Z.; Singh A.; London C.; Carson W.E.; Papenfuss, T.L.Suppression of canine myeloid cells by soluble factors from cultured canine tumor cells Veterinary Immunology and Immunopathology 2012, 145(1-2), 420-430.
  22. Jaime-Ramirez A.C.; Mundy-Bosse B.; Kondadasula S.; Jones N.B.; Roda J.M.; Mani A.; Parihar R.; Karpa V.; Papenfuss, T.L.; LaPerle K.M.; Biller E.; Lehman A.; Chaudhury A.R.; Jarjoura D.; Burry R.W.; Carson W.E. 3rd  Interleukin-12 enhances the antitumor actions of trastuzumab via NK cell IFN-ϒ production.  J. Immunology 2011, 186(6), 3401-3409.
  23. Papenfuss, T.L.; Powell N.D.; McClain M.A.; Bedarf A.; Singh A.; Gienapp I.E.; Shawler T.; Whitacre C.C. Estriol generates activated tolerogenic DCs in vivo that protect against autoimmunity.  Journal of Immunology 2011, 186(6), 3346-3355.
  24. Kithcart A.; Sielecki T.; Short A.; Pruitt J.; Papenfuss, T.L.; Shawler T.; Gienapp I.E.; Satoskar A.; Whitacre C.C.  A small molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.  FASEB Journal 2010, 24(11), 4459-4466.
  25. Papenfuss, T.L.; Kithcart A.P.; Powell N.D.; McClain M.A.; Gienapp I.E.; Shawler T.M.; Whitacre C.C. Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis. Journal of Leukocyte Biology 2007, 82(6), 1510-8.
  26. Papenfuss, T.L.; Thrash J.C.; Danielson P.E.; Foye P.E.; Hllbrush B.S.; Sutcliffe J.G.; Whitacre C.C.; Carson M.J.   Induction of Golli-MBP expression in CNS macrophages during acute LPS-induced CNS inflammation and experimental autoimmune encephalomyelitis (EAE).  The Scientific World Journal 2007, 2(7), 112-20.
  27. Rosas L.E.; Snider H.M.; Barbi J.; Satoskar A.J.; Lug-Villarino G.; Keiser T.; Papenfuss, T.L.; Durbin J.E.; Radzioch D.; Glimcher L.H.; Satoskar A.R.  Cutting edge:  STAT1 and T-bet play distinct roles in determining outcome of visceral Leishmaniasis caused by Leishmania donovani. Journal of Immunology 2006, 177(1), 22-25.
  28. Powell N.D.; Papenfuss, T.L.; McClain M.A.; Gienapp I.E.; Shawler T.M.; Satoskar A.R.; Whitacre C.C. Cutting Edge: Macrophage migration inhibitory factor is necessary for   progression of experimental autoimmune encephalomyelitis. Journal of Immunology 2005, 75(9), 5611-14.
  29. Papenfuss, T.L.; Rogers C.J.; Gienapp I.; Yurrita M.; McClain M.; Damico N.; Valo J.; Song F.; Whitacre C.C. Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains.   Journal of Neuroimmunology 2004, 150(1-2), 59-69.


Selected Book Chapters

  1. Papenfuss, T.L.; Cesta, M.L.  Immunopathology of the Spleen.  In: Immunopathology in Toxicology and Drug Development; Parker, G.A., Ed.;  Springer: In Review (Publisher) 2016.
  2. Papenfuss, T.L.; Rosas L.S.; Bolon B.  Flow cytometry and immunophenotyping in drug development in Immunopathology in toxicology and drug development. In: Immunopathology in Toxicology and Drug Development; Parker, G.A., Ed.;  Springer: In Review (Publisher) 2016
  3. Parker, G; Papenfuss, T.L.  Basic Immunobiology.  In: Immunopathology in Toxicology and Drug Development; Parker, G.A., Ed.;  Springer: In Review (Publisher) 2016
  4. Parker G.; Papenfuss, T.L. Immune System.   In  Atlas of Histology of the Juvenile Rat; Parker, G.A., Ed.; Elsevier: Academic Press, San Diego, CA 2016
  5. Papenfuss, T.L.; Baker J.  Use of Animal Models to Evaluate Myeloid Cell Dysfunction in Cancer. In Myeloid Cells: Biology & Regulation, Role in Cancer Progression and Potential Implications for Therapy; Nova Publishers: Hauppague, NY, 2013. 
  6. Papenfuss, T.L. Monocytes and dendritic cells production and distribution In: Weiss D, Wardrop KJ (eds).  Schalm’s Veterinary Hematology 6th edition; Weiss D.; Wardrop K.J.; Eds.; Oxford, Wiley-Blackwell 2010. pp. 50-55. 
  7. Papenfuss, T.L.; Whitacre C.C.  Sex hormones, pregnancy and immune function In: Hormones, Brain and Behavior; Pfaff, D.W. Ed.; Oxford: Elsevier 2009.  pp. 367-393.