Skip to main content


Selected Publications

  1. Xiang J, Rauch DA, Huey DD, Panfil AR, Cheng X, Esser AK, Su X, Harding JC, Xu Y, Fox GC, Fontana F, Kobayashi T, Su J, Sundaramoorthi H, Wong WH, Jia Y, Rosol TJ, Veis DJ, Green PL, Niewiesk S, Ratner L, Weilbaecher KN. HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia. JCI Insight. 2019 Oct 3;4(19). doi: 10.1172/jci.insight.128713. PubMed PMID: 31578308.
  2. Panfil AR, London JA, Green PL, Yoder KE. CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus. Front Microbiol. 2018;9:3107. doi: 10.3389/fmicb.2018.03107. eCollection 2018. Review. PubMed PMID: 30619186; PubMed Central PMCID: PMC6302043.
  3. Kodigepalli KM, Li M, Bonifati S, Panfil AR, Green PL, Liu SL, Wu L. SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice. Cell Cycle. 2018;17(23):2564-2576. doi: 10.1080/15384101.2018.1550955. Epub 2018 Dec 4. PubMed PMID: 30474474; PubMed Central PMCID: PMC6300106.
  4. Panfil AR, Al-Saleem J, Howard CM, Shkriabai N, Kvaratskhelia M, Green PL. Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5. Front Microbiol. 2018;9:80. doi: 10.3389/fmicb.2018.00080. eCollection 2018. PubMed PMID: 29441057; PubMed Central PMCID: PMC5797633.
  5. Kenney AD, Dowdle JA, Bozzacco L, McMichael TM, St Gelais C, Panfil AR, Sun Y, Schlesinger LS, Anderson MZ, Green PL, López CB, Rosenberg BR, Wu L, Yount JS. Human Genetic Determinants of Viral Diseases. Annu Rev Genet. 2017 Nov 27;51:241-263. doi: 10.1146/annurev-genet-120116-023425. Epub 2017 Aug 30. Review. PubMed PMID: 28853921; PubMed Central PMCID: PMC6038703.
  6. Webb LM, Amici SA, Jablonski KA, Savardekar H, Panfil AR, Li L, Zhou W, Peine K, Karkhanis V, Bachelder EM, Ainslie KM, Green PL, Li C, Baiocchi RA, Guerau-de-Arellano M. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017 Feb 15;198(4):1439-1451. doi: 10.4049/jimmunol.1601702. Epub 2017 Jan 13. PubMed PMID: 28087667; PubMed Central PMCID: PMC5292587.
  7. Panfil AR, Martinez MP, Ratner L, Green PL. Human T-cell leukemia virus-associated malignancy. Curr Opin Virol. 2016 Oct;20:40-46. doi: 10.1016/j.coviro.2016.08.009. Epub 2016 Aug 31. Review. PubMed PMID: 27591679; PubMed Central PMCID: PMC5102797.
  8. Panfil AR, Dissinger NJ, Howard CM, Murphy BM, Landes K, Fernandez SA, Green PL. Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. J Virol. 2016 Jan 27;90(7):3760-72. doi: 10.1128/JVI.03113-15. PubMed PMID: 26819304; PubMed Central PMCID: PMC4794683.
  9. Panfil AR, Al-Saleem J, Howard CM, Mates JM, Kwiek JJ, Baiocchi RA, Green PL. PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival. Viruses. 2015 Dec 30;8(1). doi: 10.3390/v8010007. PubMed PMID: 26729154; PubMed Central PMCID: PMC4728567.
  10. Panfil AR, Al-Saleem JJ, Green PL. Animal Models Utilized in HTLV-1 Research. Virology (Auckl). 2013;4:49-59. doi: 10.4137/VRT.S12140. eCollection 2013. Review. PubMed PMID: 25512694; PubMed Central PMCID: PMC4222344.
  11. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed PMID: 23678172; PubMed Central PMCID: PMC3700198.
  12. Wille CK, Nawandar DM, Panfil AR, Ko MM, Hagemeier SR, Kenney SC. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J Virol. 2013 Jan;87(2):935-50. doi: 10.1128/JVI.01790-12. Epub 2012 Nov 7. PubMed PMID: 23135711; PubMed Central PMCID: PMC3554042.
  13. Hoebe EK, Wille C, Hopmans ES, Robinson (Panfil) AR, Middeldorp JM, Kenney SC, Greijer AE. Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation. J Virol. 2012 Oct;86(20):11322-32. doi: 10.1128/JVI.01161-12. Epub 2012 Aug 15. PubMed PMID: 22896599; PubMed Central PMCID: PMC3457140.
  14. Robinson (Panfil) AR, Kwek SS, Kenney SC. The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1. PLoS Pathog. 2012 Feb;8(2):e1002516. doi: 10.1371/journal.ppat.1002516. Epub 2012 Feb 9. PubMed PMID: 22346751; PubMed Central PMCID: PMC3276558.
  15. Robinson (Panfil) AR, Kwek SS, Hagemeier SR, Wille CK, Kenney SC. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. J Virol. 2011 Sep;85(17):8940-53. doi: 10.1128/JVI.00569-11. Epub 2011 Jun 22. PubMed PMID: 21697476; PubMed Central PMCID: PMC3165789.
  16. Bristol JA, Robinson (Panfil) AR, Barlow EA, Kenney SC. The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins. J Virol. 2010 Dec;84(23):12362-74. doi: 10.1128/JVI.00712-10. Epub 2010 Sep 22. PubMed PMID: 20861254; PubMed Central PMCID: PMC2976414.
  17. Dickerson SJ, Xing Y, Robinson (Panfil) AR, Seaman WT, Gruffat H, Kenney SC. Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters. PLoS Pathog. 2009 Mar;5(3):e1000356. doi: 10.1371/journal.ppat.1000356. Epub 2009 Mar 27. PubMed PMID: 19325883; PubMed Central PMCID: PMC2654727.