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The purpose of this study is to adapt several tests of sensory and motor function commonly used in rodent SCI models for dogs and to assess the utility and reliability of these tests in measuring recovery from SCI in dogs
There is a high incidence of SCI in the general canine population, leading to a recent surge of clinical trials evaluating treatments to improve outcome. However, many clinical trials have difficulty identifying treatment effects because of a lack of sensitive and quantifiable measures to document sensory and motor recovery in dogs with SCI. There is a critical need for the development of sensitive and reliable outcome measures to assess recovery in dogs with SCI. Without reliable outcome measures, small-scale clinical trials are unlikely to identify modest but important treatment affects that would lead to larger-scale trials to benefit dogs with SCI.
We expect our results to provide multiple valuable outcome measures by which to document sensory and motor improvement in dogs with SCI. Based on preliminary data, we expect sensory testing to delineate insensate zones from normal thresholds, Catwalk data will show increasing dyscoordination with increasing SCI severity, and BBB scores will correlate with locomotor scores from a previously validated scale. This study may provide rapid clinical benefit to dogs with SCI by allowing veterinary researchers to “speak the same language” as bench-top researchers and federal agencies regarding treatment effects in therapeutic trials, opening the door to federal funding to study canine SCI by validating outcome measures necessary to draft competitive research proposals.
To qualify for enrollment in this study, dogs must:
The sponsor will cover study associated costs for screening and recheck visits plus a $200 credit at the end of the study
Please contact the Clinical Trials Office at the Veterinary Medical Center for more information about this study.