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Kaleigh Peters will tell you that her dog Macy is a typical Doberman. “She’s very smart,” Kaleigh said, adding how the 8-year-old pup loves people, knows lots of tricks, is great with kids and was easy to train.
Unfortunately, Macy has a history of chronic lameness that worsened after activity, causing her to limp. Concerned, Kaleigh scheduled an appointment for Macy with the Veterinary Medical Center’s Orthopedic Service, where she was diagnosed with osteoarthritis.
Kaleigh, also a veterinary student at The Ohio State University, was offered several treatment options from the orthopedic surgeon, including placing Macy in a clinical trial for dogs with osteoarthritis aiming to decrease inflammation in the affected joints. Kaleigh decided to go this route in hopes of delaying the need for Macy to undergo surgery. In the study, blood was collected from Macy, processed, and then a protein solution created from this blood was injected into her joint.
“As a veterinary student, I am interested in orthopedics and did some research,” Kaleigh explained. “Dr. Audrey Wanstrath’s study was perfect for Macy. I knew that it might make her more comfortable…Plus, if the procedure worked, we would learn something that could help more dogs in the future.”
With one of the largest Clinical Trials Offices in the country, there are often studies like this one that may offer new treatments that are not available elsewhere.
“I am thrilled with how well she has done in this study,” Kaleigh said. “She [Macy] is doing really well.”
Feb. 11, 2015
Winston is an 8-year-old mixed breed dog who presented to the OSU-VMC Medical Oncology Service for evaluation of a mast cell tumor that was present on the left side of his chest. The tumor had been removed twice and had grown back both times, and now was quite large. Winston was entered into the STA-1474 clinical trial evaluating a new heat shock protein 90 (HSP90) inhibitor in dogs with mast cell tumors. He did very well throughout the 5 week study, and his tumor was almost completely gone by the end of his treatment. Winston has just finished a course of radiation therapy to hopefully get rid of any remaining tumor cells and is now enjoying his time hanging out on the front porch. Thanks to Winston and his family for helping us with this study!
Misty is a 3 year old Himalayan that presented to the OSU VMC Cardiology Service for Congestive Heart Failure CHF) and hypertrophic obstructive cardiomyopathy (HOCM).
The owner was given all the possible treatment options for Misty, and decided to enroll her into a cardiology clinical trial on 10/13/11. Misty did well throughout the 180 day trial, and continued to show no signs of CHF on physical exam, echocardiogram and thoracic radiographs.
Misty completed the study last month, and at the appointment, the owner reported that Misty was doing great at home and was more active than when she started the study! She still showed no signs of CHF and the severity of her HOCM had improved since the beginning of the study. Due to these findings, we are cautiously optimistic about Misty’s long-term prognosis of living with HOCM.
Hanz is a 9.5 yr german shepherd dog that was diagnosed with OSA of the left distal radius.
He underwent limb amputation on 9/29/11 and enrolled into the Palladia/Piroxicam/Cyclophosamide Treatment for Dogs with OSA clinical trial on 10/10/11. He received 4 doses of Carboplatin every 3 weeks, and on 1/13/12 was found to be free of metatisis. He was then randomized to be in the Palladia group meaning he would receive Palladia along with his Piroxicam/Cyclophosamide. He has been on this treatment for a month and doing very well.
Hanz was a active dog and always enjoyed daily walks with his owners before his diagnosis and amputation. Like most owners, they were worried about how Hanz would handle only having 3 legs and how chemotherapy would affect his quality of life. As you can see from the picture, he has maintained a great quality of life during chemotherapy and
has noadapting to life with 3-legs.