Ongoing Clinical Research

Critical Care

December 10, 2009 - 2:30pm
The aim of this study is to determine whether abdominal effusion is present prior to cystocentesis in cats with urethral obstruction and whether effusion develops or worsens after cystocentesis is performed.
December 10, 2009 - 2:31pm
The aim of this study is to determine how often a urinary tract infection (UTI) is present before and after urethral catheterization in obstructed domestic male cats, as well as to determine the most common types of bacteria to cause a UTI in these patients along with the best type of antibiotic to use.
December 10, 2009 - 2:31pm
The goal of this study to determine the presence or absences of significant hemostatic changes in hemorrhage secondary to acute trauma in healthy, adult dogs using thromboelastography.

Shelter Medicine

December 10, 2009 - 2:35pm
The objectives of this study are to test the ability of improved observations and use of a biomarker to predict health outcomes, to determine if changes in the cage environment reduce stress, and to create a training program to help shelter workers become experts in observing and working with cats to reduce stress. The overriding goal of this project is to improve the lives of both cats and the shelter personnel who care for them.

Food Animal

December 10, 2009 - 2:35pm
The purpose of this study is to evaluate the genetics of M. haemolamae infection on virulence, presence of distinct organisms in differing location in the USA and whether or not newborn crias obtain this infection while developing inside the mother or immediately after birth (associated with consuming colostrum).
March 23, 2010 - 7:51am
The purpose of this study is to verify the utility of the presence of a white blood cell protein complex that is released during serious bacterial infections. The goal is to obtain serum samples from cattle with a variety of conditions to ensure that the serum protein complex is only present in very ill animals and not in animals with less severe diseases.
January 29, 2013 - 12:25pm
The goal of the project is to develop an effective non-antimicrobial  treatment for neonatal calf diarrhea able to be used by both conventional and organic dairy calf raisers.  Specifically, our objectives are to 1) Determine if oral administration of lactoferrin is effective in reducing the concentration of E. coli in the feces of calves; 2) Determine if administration of lactoferrin in oral rehydration solutions as a treatment for calf diarrhea results in reduced mortality or fewer antimicrobial treatments compared to oral rehydration solutions alone.

Equine

December 10, 2009 - 2:37pm
The aim of this study is to determine if bacterial translocation occurs into the portal blood stream and regional mesenteric lymph nodes from areas of strangulated bowel. This project will also determine the anatomic route for bacterial translocation and characterize the microbial species involved.
September 18, 2010 - 9:53am
The purpose of this multi-centered study is to investigate the naturally acquired infection-induced activation of inflammatory molecules on the incidence and severity of "relative adrenal insufficiency" (RAI) in foals, as well as to determine if hydrocortisone replacement therapy will alter the activation of inflammatory molecules, reduce severity of disease, and improve survival in infected foals with RAI in a clinical hospital setting.
November 12, 2010 - 2:17pm
The aim of this study is to standardize solar measurements (including the use of contrast medium application to the sole to more accurately assess sole depth) in the equine hoof. This information will help improve diagnostics, treatment and hopefully outcome of laminitic horses.
March 7, 2011 - 1:10pm
The goal of this study is to investigate a new technology called Microscan, a hand-held dark-field microscope which would allow veterinarians to evaluate the blood supply to the large colon of horses during surgery. This would help deciding how much of the colon is still viable and therefore decreasing the chances of unnecessary radical resection (colon tissue removal). The microscan results will later be correlated with standard biopsy for validation. All that is required for this study is a small biopsy of the colon during surgery and permission to obtain images with Microscan.
March 7, 2011 - 1:12pm
The goal of this study is to discover what happens to the abdominal pressure in horses with colic. We believe that increased intra-abdominal pressure occurs in horses with colic and may contribute to decreased blood flow to the organs and subsequent poor outcome. As part of this study we need to take abdominal pressure measurements during the colic examination at The Ohio State University Veterinary Medical Center.
June 2, 2011 - 11:03am
Foals with sepsis often develop dehydration, low blood pressure and poor supply to organs like the brain, kidney and intestine. We believe that blood levels of hormones that play a role on regulation of blood pressure (CRH, AVP, ACTH, Renin, Angiotensin and Aldosterone) are abnormal in septic foals and that can contribute to organ failure and death. To test the level of these hormones we will collect an extra blood sample of septic foals admitted to the hospital.
October 31, 2012 - 10:05am
Colic remains the leading cause of death in the horse. In equine colic, mortality is closely related to the degree of endotoxaemia which have been evaluated as prognostic indicators and correlated with increased mortality. Also, endotoxaemia directly contributes to the development of many life-threatening sequelae including laminitis. Despite its importance, the diagnosis of equine endotoxemia has generally been made by clinical signs.

Neurology

October 31, 2012 - 10:20am
Impaired standing balance associated with spinal cord injury (SCI) is an important cause of reduced functional ability in both dogs and people, as well as a potentially valuable quantifiable outcome measure for use in clinical trials. A number of assessment tools exist in people with SCI, but of recent note is the trend for use of the Wii Balance Board (WBB) for such assessment. The WBB is inexpensive, readily available and has shown good agreement with force platform data in human patients with various neurologic diseases.