Evaluating the Genetic Basis of Immune-Mediated Hemolytic Anemia and Immune-Mediated Thrombocytopenia

Purpose

The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.

Background

Immune-mediated diseases in dogs and cats are common, and may contribute to significant medical problems and premature death. We are recruiting dogs with primary IMHA, ITP, Addison ’s disease, and IMPA from a number of different veterinary teaching institutions. We will use these DNA samples (along with the associated phenotypic information) to conduct a genome-wide association study (GWAS) for each disease. Samples will be sent as batches to North Carolina State University College of Veterinary Medicine for targeted re-sequencing of genomic regions with single-nucleotide polymorphism (SNPs) that strongly discriminate between affected and unaffected animals. We believe that our analysis may uncover certain SNPs or haplotypes that can predict patient outcomes and response to therapy. It is our hope that by obtaining a better understanding of the pathways that cause immune-mediated diseases in dogs, more targeted therapies can be employed that lead to better outcomes in our patients.
 

Inclusion Criteria:

To qualify for enrollment in this study, dogs must have:
• IMHA
• ITP
• Addison’s Disease
• IMPA

Study Design

We will need to take a small blood sample from your dog or cat to evaluate his or her genetic makeup. During this same blood draw, we may also collect two additional vials of blood to aid in the diagnosis of your pet’s condition.

Client Compensation

• All costs associated with the blood are covered by the study.

Client Cost

• The client is responsible for all costs associated with my dog's care at OSU that are not part of this study.

Client Contact

Dr. Julien Guillaumin- (614) 292-3551