Genetics in dogs with cancer (Lymphoma and Leukemia)

 Click here to download the study flyer

Antigen receptor genes are complex genes that direct the synthesis of important cell surface receptors on immune cells called lymphocytes. Next-generation sequencing has been used to sequence these genes in humans and mice, but this technique has never been demonstrated in the dog. Thanks to work done by the Sanger Institute, we hope to use a new annotation of the canine antigen receptor genes and new computational techniques to document the usefulness of next-generation antigen receptor sequencing in the dog.

Objective of the trial:

The results of this research should allow us to determine whether the new antigen receptor gene annotation and new computational techniques we have developed are suitable to accurately identify clonal expansions of lymphocytes in dogs with naturally occurring lymphoma and leukemia.

What qualifies my dog for enrollment in this trial?

To participate in this clinical trial your dog must have:

  • A cytologic or histopathologic diagnosis of lymphoma,
  • Weigh > 7 kg
  • Never received any treatment (including steroids) for lymphoma prior to their initial visit to the OSU-VMC Integrated Oncology Service.
  • Undergo treatment other than steroids (i.e. chemotherapy)

What does enrolling my dog in this clinical trial involve?

We will collect approximately 2 teaspoons of blood (6-8 mL) in a special tube. This tube will allow us to quickly isolate the lymphocytes and process them for further analysis. If your dog has high-grade lymphoma, we will collect this blood up to two times throughout the course of your dog’s treatment: prior to starting treatment, at expected clinical remission (approximately 6 weeks after starting treatment).

You will not need to make any special visits to the OSU-VMC for this study as we will coordinate all blood draws at the time of your dog’s regular chemotherapy appointments. None of these blood draws will interfere with any chemotherapy protocols that you may choose for your dog, nor will they interfere with any other treatments your dog may be receiving.

Client Compensation

There are no costs associated with participation in this study. The study investigators will pay for the blood tubes, the blood draw, and any analyses of the blood samples we collect.

Client Contact

If you believe your pet may be eligible to enter this study, please click here to fill out a questionnaire. 

Dr. Megan Brown, brown.3100@osu.edu