The goal of this study is to prove that Pimobendan improves atrial function and thus prevents stagnating blood flow, possibly preventing the development of thromboembolic disease, a common and often deadly consequence of hypertrophic cardiomyopathy.
This study addresses the hypothesis that echocardiography can identify congestive heart failure (CHF) in cats non-invasively by predicting elevated filling pressure, respiratory rate and radiographic findings diagnostic for CHF.
Early use of a drug to break up or dissolve blood clots (Tissue Plasminogen Activator) for blood clots in cats. -- The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).
This study aims to determine blood aluminum levels in cats with chronic kidney disease. This study will also aim to determine blood aluminum levels in cats with chronic kidney disease to see if diet influences blood aluminum levels.
This project will demonstrate the value of canine studies in identifying the molecular genetic basis of behavior. The planned publication of the results of these studies will lead to the development of new effective treatments, improving the quality of patient care and quality of life of dogs. Effective veterinary treatments are also likely to translate to new human therapies.
Evaluating the Genetic Basis of Immune-Mediated Hemolytic Anemia and Immune-Mediated Thrombocytopenia. -- Purpose: The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.
Brainstem auditory evoked response (BAER) testing in normal hearing cavalier king charles spaniel dogs. -- Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss. This is a 1-day study. Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.
Protein in the urine (proteinuria) is common in dogs and causes further damage to the kidneys. This study aims to determine whether the standard drugs used to treat proteinuria can completely suppress one of the hormones involved in kidney regulation, and whether lack of complete suppression affects the amount of proteinuria.
Syringomyelia (SM) is a painful neurological problem which causes neuropathic pain (NP) behaviors such as scratching, face rubbing, and intermittent vocalizations in affected dogs. Pain management of SM-NP is currently limited by the lack of objective ways to assess severity of pain in dogs with the condition. The long-term goal of our group is to improve the diagnosis and management of neuropathic pain in dogs.
Diagnosing and managing neuropathic pain in dogs with spinal cord injury (SCI). The purpose of this study to monitor dogs for the development of neuropathic pain after SCI, and to test medication effects and inter-observer agreement of a technique to quantify neuropathic pain. We will correlate these results with force plate data from dogs at the same visit.
Evaluation of sensory dysfunction in Cavalier King Charles Spaniels with and without Chiari malformation/syringomyelia. -- The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
In this study, we aim to use a new approach to stimulate the body’s own immune system to attack remaining tumor cells in dogs that have undergone standard of care limb amputation and chemotherapy for the treatment of bone tumors (Osteosarcoma).
The purposes of the study are to assess feasibility and safety of the microwave ablation therapy for the treatment of distal radial osteosarcomas in dogs, to measure the volume of treated tissue and to record the presence of collateral damages (soft tissue).
The results of this research should allow us to determine whether the new antigen receptor gene annotation and new computational techniques we have developed are suitable to accurately identify clonal expansions of lymphocytes in dogs with naturally occurring lymphoma and leukemia.
The purposes of the study are to assess clinical efficacy, to record the associated complications (intra and post-operative complications) and the potential effects on long term survival of the microwave ablation therapy for the treatment of liver/pulmonary/renal metastatic diseases.
Correlation of plasma levels of a potential biomarker (CK-18) with diarrhea in dogs with mast cell tumor treated receiving toceranib (Palladia). -- The purpose of this pilot study is to determine if plasma CK18 levels can be used as a biomarker that can predict GI side effects in dogs receiving toceranib.
The objective of this study is to evaluate the relative effectiveness of an investigational drug (D929) when applied topically to the eye at various dose levels under field conditions in dogs with dry eye.
This study will determine if tapentadol causes relief of pain when given by mouth to dogs experiencing pain. These results will provide veterinarians with essential information for tapentadol dosing to treat pain in dogs. This knowledge should help veterinarians address both acute and chronic pain.
The aim of this study is to evaluate a novel computed tomography (CT)-based quantitative index of airflow resistance in brachycephalic dogs before and after surgical intervention including the ablation of nasal turbinates.
Evaluation of a parathyroid hormone test in dogs undergoing parathyroid gland removal. -- The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.