Current Trials

Cat

Emergency and Critical Care

June 28, 2015 - 4:00pm
Purpose: The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).
June 28, 2015 - 4:00pm
Purpose: This study aims to determine whether cystocentesis helps to increase the ease of passing a urinary catheter, and thereby trauma to the urethra.

Internal Medicine

June 28, 2015 - 4:00pm
Purpose: The purpose of this study is to develop a test for early diagnosis of pre-diabetes, prior to the presence of clinical signs of diabetes. In the future this will enable implementation of targeted preventive measures to slow or prevent the progression from pre-diabetes to diabetes in cats at risk.
Dog

Heart (Cardiology)

June 28, 2015 - 4:00pm
Purpose: The objective of this study is to assess right ventricular (RV) function in dogs at various stages of myxomatous mitral valve degeneration (MMVD).
June 28, 2015 - 4:00pm
Purpose: The goal of this study is to use the newest generation of cardiac CT scanners to investigate the coronary circulation of English bulldogs.
June 28, 2015 - 4:00pm
Purpose: This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.

Emergency and Critical Care

June 28, 2015 - 4:00pm
Purpose: The purpose of this clinical trial is to assess the effectiveness of thromboelastography, which is a method of testing the efficiency of blood coagulation, in dogs receiving blood transfusions. 
June 28, 2015 - 4:00pm
Purpose: To evaluate canine stomach serosa microcirculation in patients undergoing anesthesia for routine spay and stomach tacking, and determine correlation between stomach serosal and cheek mucosal microcirculatory parameters.
June 28, 2015 - 4:00pm
Purpose: To evaluate the gastric serosal microcirculation in canine patients with naturally occurring GDV and to determine if buccal mucosa microcirculation or systemic parameters may serve as a surrogate, and compare gastric microcirculatory assessment to intra-operative determination of tissue viability.
June 28, 2015 - 4:00pm
Purpose: The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.

Skin and Ears (Dermatology and Otology)

August 11, 2015 - 1:56pm
The objective of this study is to see if low-level laser therapy is an effective adjunctive treatment for acral lick dermatitis (ALD).  
June 28, 2015 - 4:00pm
Purpose: The objective of this study is to assess changes in dermal mast cell numbers before, during and after treatment. Additionally, we will evaluate the change in the patient’s clinical signs, itching level and quality of life prior to, during and following administration of anti-KIT monoclonal antibody.
June 28, 2015 - 4:00pm
Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss.  This is a 2-day study.  Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.

Internal Medicine

June 28, 2015 - 4:00pm
Purpose: The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.
June 28, 2015 - 4:00pm
Purpose: The purpose of this study is to determine how amino acid status and markers of inflammation are affected in dogs with PLN. We will evaluate plasma amino acid concentrations and markers of inflammation [C-reactive protein (CRP); tumor-necrosis factor-α (TNF- α); interleukin-6 (IL-6)] in order to then develop novel medical and dietary therapeutic strategies for dogs with PLN.

Brain and nervous system (Neurology and Neurosurgery)

June 28, 2015 - 4:00pm
Purpose: In both dogs and people with Chiari malformation/syringomyelia (CM/SM), there is a high documented incidence of hyperesthesia (lowered pain threshold). The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
June 28, 2015 - 4:00pm
Purpose: The purpose of our research is to evaluate the usefulness of kinematic MRI in dogs with CSM. This project will further our current understanding of CSM, and will lead to a better understanding of the mechanisms associated with the disease and refinement of treatment strategies.

Cancer (Oncology)

July 16, 2015 - 11:43am
The purpose of this study is to collect plasma and a lymph node sample from dogs with lymphoma so that we can evaluate the activity of LY against the lymphoma cells in the laboratory. The plasma will be used to see if there are high levels of folate in the bloodstream of dogs with lymphoma and to get a sense as to whether the LY may work well in affected dogs.
June 28, 2015 - 5:00pm
Purpose: The purpose of this study is to evaluate the biologic activity of Verdinexor when it is administered in combination with therapeutic doses of prednisone in dogs with lymphoma.
June 28, 2015 - 4:59pm
Purpose: The purpose of this clinical trial is to evaluate the activity of KPT-9274 in dogs with lymphoma, to measure blood levels of KPT-9274 in dogs with lymphoma to see how well the drug is absorbed, and to evaluate lymph node samples and to assess well KPT-9724 inhibits PAK4 activation in the tumor cells.
June 28, 2015 - 4:00pm
Purpose: The goal of this multi-centered trial is to evaluate the effectiveness of toceranib for the treatment of dogs with osteosarcoma that has spread to the lung, and to evaluate markers in the blood that may help to determine which dogs will benefit most from toceranib treatment.

Soft Tissue Surgery

June 28, 2015 - 6:00pm
Purpose: The aim of this pilot study is to evaluate a novel computed tomography (CT)-based quantitative index of airflow resistance in brachycephalic dogs before and after surgical intervention.
June 28, 2015 - 4:00pm
Purpose: The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.