Purpose: The purpose of this study is to develop a test for early diagnosis of pre-diabetes, prior to the presence of clinical signs of diabetes. In the future this will enable implementation of targeted preventive measures to slow or prevent the progression from pre-diabetes to diabetes in cats at risk.
Purpose: This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.
Purpose: The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.
Purpose: The purpose of this clinical trial is to assess the effectiveness of thromboelastography, which is a method of testing the efficiency of blood coagulation, in dogs receiving blood transfusions.
Purpose: To evaluate canine stomach serosa microcirculation in patients undergoing anesthesia for routine spay and stomach tacking, and determine correlation between stomach serosal and cheek mucosal microcirculatory parameters.
Purpose: To evaluate the gastric serosal microcirculation in canine patients with naturally occurring GDV and to determine if buccal mucosa microcirculation or systemic parameters may serve as a surrogate, and compare gastric microcirculatory assessment to intra-operative determination of tissue viability.
Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss. This is a 2-day study. Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.
Purpose: The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.
Purpose: The purpose of this study is to determine how amino acid status and markers of inflammation are affected in dogs with PLN. We will evaluate plasma amino acid concentrations and markers of inflammation [C-reactive protein (CRP); tumor-necrosis factor-α (TNF- α); interleukin-6 (IL-6)] in order to then develop novel medical and dietary therapeutic strategies for dogs with PLN.
Brain and nervous system (Neurology and Neurosurgery)
The purpose of this study is to monitor dogs for the development of neuropathic pain after SCI, and to test medication effects and inter-observer agreement of a technique to quantify neuropathic pain. We will correlate these results with force plate data from dogs at the same visit.
Purpose: In both dogs and people with Chiari malformation/syringomyelia (CM/SM), there is a high documented incidence of hyperesthesia (lowered pain threshold). The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
The Ohio State University-Clinical Trials Office (OSU-CTO) is currently enrolling cases in a nationwide clinical trial to evaluate safety and efficacy of a novel PI3 Kinase Delta Inhibitor (RV1001) in dogs with naïve or first relapse lymphoma.
The purpose of this clinical trial is to evaluate the activity of KPT-9274 in dogs with solid tumors, to measure blood levels of KPT-9274 in dogs with solid tumors to see how well the drug is absorbed, and to evaluate lymph node or tumor samples and to assess well KPT-9724 inhibits PAK4 activation in the tumor cells.
Purpose: The goal of this multi-centered trial is to evaluate the effectiveness of toceranib for the treatment of dogs with osteosarcoma that has spread to the lung, and to evaluate markers in the blood that may help to determine which dogs will benefit most from toceranib treatment.
Purpose: The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.