Purpose: The purpose of this study is to develop a test for early diagnosis of pre-diabetes, prior to the presence of clinical signs of diabetes. In the future this will enable implementation of targeted preventive measures to slow or prevent the progression from pre-diabetes to diabetes in cats at risk.
Purpose: This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.
Purpose: The purpose of this clinical trial is to assess the effectiveness of thromboelastography, which is a method of testing the efficiency of blood coagulation, in dogs receiving blood transfusions.
Purpose: To evaluate canine stomach serosa microcirculation in patients undergoing anesthesia for routine spay and stomach tacking, and determine correlation between stomach serosal and cheek mucosal microcirculatory parameters.
Purpose: To evaluate the gastric serosal microcirculation in canine patients with naturally occurring GDV and to determine if buccal mucosa microcirculation or systemic parameters may serve as a surrogate, and compare gastric microcirculatory assessment to intra-operative determination of tissue viability.
Purpose: The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.
Purpose: The objective of this study is to assess changes in dermal mast cell numbers before, during and after treatment. Additionally, we will evaluate the change in the patient’s clinical signs, itching level and quality of life prior to, during and following administration of anti-KIT monoclonal antibody.
Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss. This is a 2-day study. Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.
Purpose: The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.
Purpose: The purpose of this study is to determine how amino acid status and markers of inflammation are affected in dogs with PLN. We will evaluate plasma amino acid concentrations and markers of inflammation [C-reactive protein (CRP); tumor-necrosis factor-α (TNF- α); interleukin-6 (IL-6)] in order to then develop novel medical and dietary therapeutic strategies for dogs with PLN.
Brain and nervous system (Neurology and Neurosurgery)
Purpose: In both dogs and people with Chiari malformation/syringomyelia (CM/SM), there is a high documented incidence of hyperesthesia (lowered pain threshold). The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
Purpose: The purpose of our research is to evaluate the usefulness of kinematic MRI in dogs with CSM. This project will further our current understanding of CSM, and will lead to a better understanding of the mechanisms associated with the disease and refinement of treatment strategies.
The purpose of this study is to collect plasma and a lymph node sample from dogs with lymphoma so that we can evaluate the activity of LY against the lymphoma cells in the laboratory. The plasma will be used to see if there are high levels of folate in the bloodstream of dogs with lymphoma and to get a sense as to whether the LY may work well in affected dogs.
Purpose: The purpose of this clinical trial is to evaluate the activity of KPT-9274 in dogs with lymphoma, to measure blood levels of KPT-9274 in dogs with lymphoma to see how well the drug is absorbed, and to evaluate lymph node samples and to assess well KPT-9724 inhibits PAK4 activation in the tumor cells.
Purpose: The goal of this multi-centered trial is to evaluate the effectiveness of toceranib for the treatment of dogs with osteosarcoma that has spread to the lung, and to evaluate markers in the blood that may help to determine which dogs will benefit most from toceranib treatment.
Purpose: The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.