Current Trials

Cat

Heart (Cardiology)

This study addresses the hypothesis that echocardiography can identify congestive heart failure (CHF) in cats non-invasively by predicting elevated filling pressure, respiratory rate and radiographic findings diagnostic for CHF.    

Emergency and Critical Care

Decompressive cystocentesis for treatment of feline urethral obstruction. --Purpose: This study aims to determine whether cystocentesis helps to increase the ease of passing a urinary catheter, and thereby trauma to the urethra.
Early use of a drug to break up or dissolve blood clots (Tissue Plasminogen Activator) for blood clots in cats. -- The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE).

Internal Medicine

The purpose of this study is to determine whether there is a significant difference in Aluminum levels between healthy cats and those with various stages of chronic kidney disease (CKD).
The purpose of this study is to evaluate the efficacy of a new diet specially formulated to dissolve struvite stones in the bladders of cats.  
Extending remission (Insulin-independent state) time in former diabetic cats. -- The purpose of this study is to evaluate the benefit of Bydureon for maintaining diabetic cats in remission (in an insulin-independent state).
Incretin-Based Tests for Early Diagnosis of Diabetes in Cats. -- Purpose: The purpose of this study is to develop a test for early diagnosis of pre-diabetes, prior to the presence of clinical signs of diabetes. In the future this will enable implementation of targeted preventive measures to slow or prevent the progression from pre-diabetes to diabetes in cats at risk.
Dog

Emergency and Critical Care

Evaluating the Genetic Basis of Immune-Mediated Hemolytic Anemia and Immune-Mediated Thrombocytopenia. -- Purpose: The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.

Skin and Ears (Dermatology and Otology)

The primary objectives of this pilot study are to evaluate the blood levels of an investigational drug (RV2001), and to assess its overall effect on the severity of clinical signs associated with atopic dermatitis in dogs.
Evaluation of Allergenic Extract Intradermal Threshold Concentration Variation in Non-Allergic Dogs. -- The purpose of this study is to establish threshold concentrations of allergens by a new veterinary allergen company.
Low-Level laser therapy as an adjunctive treatment for canine acral lick dermatitis. -- The objective of this study is to see if low-level laser therapy is an effective adjunctive treatment for acral lick dermatitis (ALD).  
Brainstem auditory evoked response (BAER) testing in normal hearing cavalier king charles spaniel dogs. -- Purpose: To obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss.  This is a 2-day study.  Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.

Internal Medicine

This study aims to look further into pain management associated with urologic endoscopy (cystoscopy), a common diagnostic tool in use for the evaluation of lower urinary tract disorders in dogs.

Brain and nervous system (Neurology and Neurosurgery)

Diagnosing and managing neuropathic pain in dogs with spinal cord injury (SCI). The purpose of this study to monitor dogs for the development of neuropathic pain after SCI, and to test medication effects and inter-observer agreement of a technique to quantify neuropathic pain. We will correlate these results with force plate data from dogs at the same visit.  
Evaluation of sensory dysfunction in Cavalier King Charles Spaniels with and without Chiari malformation/syringomyelia. -- The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.

Cancer (Oncology)

The primary objective of this study is to evaluate the activity of an investigational drug given to dogs with lymphoma that have not yet been treated or have failed chemotherapy. 
Correlation of plasma levels of a potential biomarker (CK-18) with diarrhea in dogs with mast cell tumor treated receiving toceranib (Palladia). -- The purpose of this pilot study is to determine if plasma CK18 levels can be used as a biomarker that can predict GI side effects in dogs receiving toceranib.
Evaluation of safety and effectiveness of standard of care therapy, with or without adjuvant rapamycin administration in dogs with bone tumors (osteosarcoma). -- This study will evaluate if orally administered rapamycin following Standard of Care improves long-term disease control in dogs with osteosarcoma.

Bones and joints (Orthopedic Surgery)

This study will determine if tapentadol causes relief of pain when given by mouth to dogs experiencing pain. These results will provide veterinarians with essential information for tapentadol dosing to treat pain in dogs. This knowledge should help veterinarians address both acute and chronic pain.
We aim to determine whether changes in jump height have a significant impact on the force applied to the forelimb upon landing.

Soft Tissue Surgery

Evaluation of a parathyroid hormone test in dogs undergoing parathyroid gland removal. -- The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.