Completed Clinical Trials

Oncology/Radiation Oncology

June 3, 2008 - 4:57pm
Purpose This is an NIH/NCI-sponsored multisite two-part study that will evaluate the potential efficacy and safety of a combination of 2 cytokines, each of which has shown antineoplastic activity in human and animal protocols, into a single localized, rather than systemic, therapy for canine soft tissue sarcomas, lymphomas, and melanomas. This first study is designed to determine an optimally effective and well-tolerated dose through controlled dose escalation.
June 3, 2008 - 4:57pm
Rapamycin in Dogs with Osteosarcoma (OSA) All potentially interested veterinarians and owners: PLEASE read the section NOTE TO OWNERS below, concerning the dosing of the drug. Study Title Evaluation of the mTOR Inhibitor Rapamycin in Dogs with Osteosarcoma. A multi-center national trial sponsored by the National Cancer Institute (NCI), Comparative Oncology Program, Comparative Oncology Trials Consortium, and the Morris Animal Foundation
March 11, 2009 - 11:31am
Purpose To define and compare three schedules for chronic delivery of rapamycin using a variety of biological endpoints. Dogs will be monitored to determine if objective antitumor activity is associated with rapamycin administration in dogs with established lung metastasis.
June 29, 2009 - 11:00am
Purpose To determine the effectiveness of combined carboplatin and gemcitabine chemotherapy for the treatment of osteosarcoma in dogs following amputation.
November 2, 2009 - 4:17pm
Purpose of Study This study will evaluate the efficacy (tumor response) and safety of Paclical® Vet (a new formulation of taxol) compared to CeeNu® (lomustine) for the treatment of mast cell tumors in dogs.
February 17, 2010 - 9:40pm
Purpose To purpose of this study is to evaluate the safety and effectiveness of a novel vascular disrupting agent (VDA), STA-2700 HCl, in dogs with soft tissue sarcomas.
March 22, 2010 - 10:57am
Study title Dietary Nucleotides in Dogs Undergoing Anticancer Chemotherapy Purpose of study The purpose of this study is to determine whether the addition of dietary nucleotides alters immune responses in dogs undergoing chemotherapy for lymphoma and osteosarcoma.
March 23, 2010 - 7:54am
Purpose The goal of this study is to determine the accuracy of computed tomography (CT) scans in determining tumor size in dogs with osteosarcoma of the limbs.
March 23, 2010 - 7:59am
Purpose To determine the potential biologic activity of RENCA cancer-cell-containing macrobeads implanted in dogs with hemangiosarcoma (HSA) as compared to historical control animals.
April 15, 2010 - 9:26am
Purpose The purpose of this study is to determine the maximally tolerated dose of Palladia when used in combination with 4 weekly standard doses of vinblastine in dogs with mast cell tumors
May 5, 2010 - 10:58am
Purpose The goal of this study is to determine the anti-tumor activity of Palladia against canine hemangiosarcoma.
May 24, 2010 - 11:50am
Purpose The goal of this study is to determine whether the addition of radiation therapy to Palladia will result in a higher likelihood of tumor shrinkage, and/or a longer duration of improvement.
August 24, 2010 - 9:12am
Study title Oligonucleotide microarray gene expression profiling of canine lymphoma.
August 24, 2010 - 9:12am
Study title Genome scanning for aberrant DNA methylation in canine lymphoma. Purpose of study DNA promoter methylation frequently occurs in human cancers. We hypothesize that methylation plays a key role in canine lymphoma.This study will uncover key cancer genes that may serve as diagnostic markers and targets for molecular therapies in the future. Inclusion criteria Dogs must have a diagnosis of multicentric lymphoma with no evidence of circulating neoplastic lymphocytes and no previous therapy.
August 24, 2010 - 9:12am
Study title Rapid release paclitaxel particles for intravesical treatment of transitional cell carcinoma of the bladder. Purpose of study The goal of this study is to evaluate the targeting advantage of paclitaxel-loaded particles in treatment of transitional cell carcinomas (TCC) of the bladder in dogs.
September 18, 2010 - 9:45am
Purpose This is an NIH/NCI-sponsored multisite two-phase open-label, prospective preclinical study that will evaluate the safety and effectiveness of Topotecan and novel Topoisomerase I inhibitors when given to dogs with lymphoma. The first phase is designed to determine an optimally effective and well-tolerated dose through controlled dose escalation. The second phase will be a validation for biological assay development. Anti-cancer activity against canine lymphoma will be assessed in both phases.
September 18, 2010 - 10:06am
Purpose of study The goal of this study is to determine the pharmacokinetics (blood levels) of Palladia given to dogs with cancer at doses lower than that recommended on the label.
December 1, 2010 - 12:24pm
This Study is closed. Purpose of Study The purpose of this clinical trial is to evaluate the activity of piroxicam/cyclophosphamide versus Palladia/piroxicam/cyclophosphamide in dogs with OSA following amputation and standard chemotherapy and to compare this with a historical group of dogs treated with chemotherapy alone.
December 15, 2010 - 1:53pm
Purpose of Study The purpose of this study is to identify the activity of toceranib phosphate (Palladia) alone or as a radiation sensitizing agent in the treatment of feline oral squamous cell carcinoma.
February 7, 2011 - 5:56pm
This study has closed as of 1/30/2013 Purpose of Study The purpose of this study is to define the biologic activity of Palladia alone or in combination with radiation therapy for the treatment of nasal carcinoma.
April 23, 2011 - 11:12pm
Purpose The goal of this study is to determine the anti-tumor activity of gold nanorods against solid tumors in dogs
July 18, 2011 - 1:58pm
Purpose The goal of this study is to determine if dosing STA-1474 on two consecutive days can be tolerated, and if so, identify the maximum tolerated dose; and determine the pharmacokinetic profiles of STA-1474 over the course of drug infusion.
August 30, 2011 - 8:20am
This Clinical Trial is Closed. Purpose The primary objective of this multi-institutional exploratory study is to describe the safety and efficacy of three dosages of an intravenous infusion of C. novyi-NT spores, with and without concomitant therapy, in dogs with spontaneous tumors.
December 5, 2011 - 4:38pm
This study is closed. (11/9/12) Purpose of Study The purpose of this study is to evaluate the safety and tolerability of KPT-335 given on a compassionate use basis to dogs with Lymphoma Background
December 6, 2011 - 11:02am
Purpose The goal of this study is to determine response rates in dogs with mast cell tumors recieving STA-1474 using 4 different dosing regimens.
January 8, 2012 - 9:42pm
Purpose  This study is a multi-center effort led by Dr. Doug Thamm at Colorado State University to determine the maximum tolerated dose, tolerability and adverse effect profile of combined treatment with pulse-dose toceranib and lomustine in dogs with MCT. He also would like to determine the response rate and progression-free interval in dogs with measurable MCT treated with combined pulse-dose toceranib and lomustine.
March 7, 2012 - 9:44am
The Ohio State University Clinical Trials Office at the Veterinary Medical Center is currently recruiting dogs diagnosed with malignant mammary carcinoma, melanoma, oral squamous cell carcinoma, or soft tissue sarcoma to participate in a clinical trial to explore and define the biological changes in these tumors and normal tissues following exposure to the chemotherapeutic drug iniparib.
April 11, 2012 - 9:10am
This study has ended. Thanks to all that participated. Purpose of Study The purpose of this initial pilot pharmacokinetic study is to confirm the prolonged plasma exposure of STA-12-4049 in dogs with cancer prior to performing a larger study that would evaluate the biologic activity of Elesclomol in dogs with cancer.
December 3, 2012 - 9:07am
Purpose of Study The purpose of this study is to evaluate the safety and antitumor activity of KPT-335 in dogs with lymphoma in first relapse after completion of a single chemotherapy protocol (multi-agent or single agent).

Cardiology

June 23, 2009 - 2:10pm
Dogs are now being enrolled in a clinical study that seeks to utilize cardiac ultrasound to identify and stage congestive heart failure (CHF) in dogs. Dogs with asymptomatic dilated cardiomyopathy (DCM) and degenerative mitral valve disease (MVD) and dogs with CHF caused by MVD or DCM will be enrolled. Any dog with DCM or MVD unless treated with high doses of diuretics and no concurrent systemic disease is eligible.
December 10, 2009 - 2:28pm
Purpose This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.
February 10, 2010 - 1:57pm
Purpose The purpose of this study is to establish normal blood pressure ranges in Shetland Sheep dogs, to evaluate how many asymptomatic Shetland Sheepdogs have high blood pressure, and to correlate blood pressure measurement with protein loss from the kidneys.
October 13, 2010 - 8:53pm
View the study flyer Purpose This randomized, double-blind, active-control single-dose study addresses the hypothesis that ivabradine does reduce dynamic obstruction of the left ventricular outflow tract in cats with Hypertrophic cardiomyopathy (HCM).
August 30, 2011 - 11:03am
This study is closed (8/29/2012) Purpose of the study: The purpose of this study is to determine whether chronic oral administration of pimobendan in dogs with evidence of increased heart size secondary to preclinical myxomatous mitral valve disease, can delay the onset of signs of congestive heart failure.

Dermatology/Otology

June 29, 2009 - 11:01am
Comparison of Radiographic and Computed Tomography Imaging for the Diagnosis of Caudal Occipital Malformation Syndrome (COMS) in Cavalier King Charles Spaniels (8-15-2007) Purpose This study has 2 major areas of interest:
March 5, 2010 - 4:21pm
Purpose The purpose of this study is to find and develop effective and more economical diagnostic tests for otitis media in the Cavalier King Charles Spaniels than the currently used CT scan, and to see if and to what extent auditory function is restored with current treatment methods.
March 5, 2012 - 12:26pm
Purpose:  A multi-center clinical trial evaluating the safety and efficacy of a combination of products for the treatment of allergic dermatitis in dogs
December 3, 2012 - 9:42am
Study is opening soon. If you have a potential patient that maybe eligible for enrollment please contact Dr. Hillier (hillier [dot] 4 [at] osu [dot] edu). Purpose:   The purpose of this study is to evaluate whether this vaccine reduces the clinical signs and pruritus associated with canine atopic dermatitis.

Internal Medicine

December 10, 2009 - 2:25pm
The goal of this study is to evaluate the safety and effectiveness of an alternative antibiotic treatment protocol for uncomplicated lower urinary tract (bladder) infection in dogs Background A bacterial Infection in the lower urinary tract involves the bladder and urethra, which most often is resolved by administering antibiotics. Veterinarians are increasingly interested in dosing programs that reduce the time that animals and bacteria are exposed to antibiotics in order to minimize the risk of resistance development.
October 24, 2011 - 2:42pm
Purpose of the study The purpose of this study is to determine if higher doses of enalapril than those currently recommended will further reduce urine protein excretion in dogs with glomerular disease, will survival time, slow rate of decline in kidney function, and delay onset of azotemia as compared to the standard enalapril dose.

Radiology

June 28, 2010 - 12:55pm
Purpose The goal of this study is to determine if computed tomography (CT) is more accurate for detecting canine intestinal obstruction than abdominal radiographs. We expect using CT will be more sensitive, specific, accurate and have better ROC curves than using abdominal radiographs.
September 18, 2010 - 9:59am
Positron emission tomography (PET) is an emerging imaging technology. It is becoming the standard of care for function imaging of tumors. To improve anatomic detail, PET studies are fused with computed tomographic studies (CT). Most PET studies use 18F-FDG as a glucose analog. Any lesion with increased glucose metabolism will have increased uptake of 18F-FDG. This helps distinguish between sites of active and normal glucose metabolism. Increased glucose metabolism occurs before enlargement of organs, allowing earlier detection of lesions.

Ophthalmology

June 28, 2010 - 1:06pm
Purpose To evaluate the safety and effectiveness of a new formulation of a topical drug, cyclosporine, currently used to treat Keratoconjunctivitis Sicca (KCS), commonly called "Dry Eye."
November 30, 2011 - 1:08pm
      Purpose of Study The goal of this study is to evaluate ZP-1 (P-1046) is a topical ophthalmic prescription pharmaceutical product for the treatment of canine keratoconjunctivitis sicca that is administered as a twice per day topical eye drop. 

Orthopedic Surgery

September 16, 2010 - 5:12pm
Purpose of Study The goal of this study is to determine if a single intra-articular joint injection of autologous platelet concentrate processed using a filter-based platelet harvest device can improve lameness and joint pain, as determined by force plate kinetic analysis and visual analog scores of lameness and pain, in dogs with natural-occurring osteoarthritis compared with saline injected controls.

Equine

June 2, 2011 - 11:33am
  Purpose of the study The goal of this study is to test the ability of a concentrated, activated, autologous blood solution to increase therapeutic mediators in joints and reduce lameness in horses with osteoarthritis.

Neurology

November 30, 2011 - 3:30pm
Purpose of Study The specific objectives of this study are to characterize specific inflammatory responses in the spinal fluid of dogs with acute SCI, , and correlate the degree of those responses with initial injury severity and long-term outcome