College of Veterinary Medicine

Education and Speciality Training

• Diplomate,American College of Veterinary Pathologists-Anatomic Pathology, 1987
• PhD, Ohio State University, Veterinary Pathobiology, 1986
• DVM, University of Illinois (Valedictorian, 1^st of 86 students), 1981
• BS, University of Illinois, Agricultural Science (highest honors), 1978

Research Interests

• Parathyroid Hormone-Related Protein (PTHrP):
  • Pathogenesis in humoral hypercalcemia of malignancy
  • Regulation in normal and neoplastic keratinocytes
  • Regulation in lactation and mammary carcinomas
  • Development of a Cre/LoxP Mammary Gland Specific "Knock-Out" Transgenic Mice
  • Regulation of mRNA expression and stability by transforming growth factor-beta
  • Role in cancer metastases in bone
  • Role in bone resorption associated with Human T-Lymphotropic-I Virus infection and canine lymphoma
  • Regulation of PTHrP mRNA expression by Tax and HTLV-1 virus
• Animal Models of Human Disease:
  • Paraneoplastic Syndromes
  • Endocrinology
  • Bone Disease, Bone Remodeling, Bone Metastasis
  • Prostate Cancer and Osteoblastic Metastasis
  • Breast, Lung, and Head & Neck Cancer and Osteolytic Bone Metastasis