The 2001 Distinguished Research Career Awardee is Dr. Julie M. Overbaugh, Member, Fred Hutchinson Cancer Research Center, and Affiliate Professor, Department of Microbiology in the School of Medicine at the University of Washington. Dr. Overbaugh has made seminal contributions to the understanding of retrovirus evolution, transmission, and pathogenesis of three retroviruses, Human Immunodeficiency Virus (HIV), Simian Imuunodeficiency Virus (SIV), and Feline Leukemia Virus (FeLV). The primary goal of Dr. Overbaugh's research is to determine why some retrovirus variants are more transmissible and why others are more cytopathic for lymphocytes and more pathogenic in the host. Additionally, Dr. Overbaugh as a member of the Nairobi HIV/STD Project plays a significant role in studying the molecular epidemiology of HIV transmission by analyzing viral variants in women and children. A vital part of this project is to examine the efficacy of various intervention strategies to limit the spread of HIV, particularly those that may be practical to implement in Africa. Her seminar presentation was entitled "Variation During Retroviral Infections: Implications for Transmission and Pathogenesis".