Current Recruiting Clinical Trials

Equine

December 10, 2009 - 1:25pm
Purpose of study To demonstrate an efficacy and safety of cell-mediated molecular therapy for bone disorders and bone regeneration in horses with bone lesions.
November 15, 2013 - 1:07pm
Purpose Equine dental stem cells (DSCD) are a regenerative medicine product that may produce sign modifying effects in horses with superficial digital tendonitis, desmitis, or osteoarthritis.
November 15, 2013 - 2:48pm
Purpose To evaluate the effectiveness and safety of a topical fentanyl solution compared to a control vehicle solution to reduce musculoskeletal pain.

Ophthalmology

June 28, 2010 - 12:11pm
Purpose To determine if the currently used location and energy settings for semiconductor diode laser trans-scleral cyclophotocoagulation are appropriate for buphthalmic equine globes.

Orthopedic Surgery

September 18, 2010 - 9:10am
Purpose The purpose of this study is to compare the effectiveness of cemented versus cementless canine total knee replacement.
January 15, 2014 - 9:39am
Purpose The purpose of this clinical trial is to establish the effectiveness and safety of the Harmonic Aries Blade (Ethicon Inc.) in dogs with spontaneous disk disease requiring decompressive surgery. Background

Oncology/Radiation Oncology

May 9, 2011 - 1:54pm
The Purpose The goal of this study is to assess efficacy of Palladia and Vinblastine combined for treatment of canine transitional cell carcinoma and to compare computerized tomography and ultrasound for measurement of tumor response.
April 11, 2012 - 8:17am
Purpose The purpose of this trial evaluating three structurally related chemotherapy drugs is to define their safety, pharmacokinetics, and pharmacodynamic modulation.
April 9, 2014 - 11:10am
Purpose The goal of this multi-centered trial is to evaluate the effectiveness of toceranib for the treatment of dogs with osteosarcoma that has spread to the lung, and to evaluate markers in the blood that may help to determine which dogs will benefit most from toceranib treatment.
April 14, 2014 - 11:52am
Purpose To determine whether adding tetrathiomolybdate (TM) to standard chemotherapy treatment for OSA after limb amputation will help to prevent or slow the growth of tumor spread in the lungs of affected dogs.
July 16, 2014 - 3:46pm
Purpose The primary objective of this study is to compare the safety and efficacy of masitinib to placebo in the treatment of aggressive mast cell tumors that cannot be removed with surgery.
July 22, 2014 - 3:40pm
Purpose The objective of this study is to determine the maximum tolerated dose of STA-12-8960 in dogs with cancer, and to provide information about the ability of STA-12-8960 to induce responses in dogs with spontaneous tumors.
July 23, 2014 - 10:01am
Purpose The primary objectives of this study is to identify the maximum tolerated dose of RV1001 in dogs with lymphoma and leukemia and to evaluate the ability of RV1001 to induce responses in dogs with lymphoma or leukemia that have not yet been treated or have failed chemotherapy.
July 28, 2014 - 11:15am
Purpose of Study This is an open-label, dose-escalation study evaluating the activity of ACP-196 in combination with ACP-319 given to dogs with B-cell lymphoma.
October 2, 2014 - 7:29am
Purpose The objective of this study is to assess changes in KIT expression and to assess response to therapy in dogs with MCT following administration of an anti-KIT monoclonal antibody.

Dermatology/Otology

April 19, 2012 - 4:00pm
Purpose of Study The purpose of this study is to obtain BAER data from normal hearing CKCS dogs between the ages of 1 to 2 years old with no history of hearing loss.  This is a 2-day study.  Procedures performed include hearing testing (BAER test), a Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI); study pays for all testing.

Critical Care

February 11, 2013 - 11:50am
Purpose The purpose of this clinical trial is to assess the effectiveness of thromboelastography in dogs receiving blood transfusions. 
November 15, 2013 - 2:42pm
Purpose To evaluate canine gastric serosa microcirculation in patients undergoing anesthesia for routine ovariohysterectomy and prophylactic gastropexy, and determine correlation between gastric serosal and buccal mucosal microcirculatory parameters
November 15, 2013 - 2:45pm
Purpose To evaluate the gastric serosal microcirculation in canine patients with naturally occurring GDV and to determine if buccal mucosa microcirculation or systemic parameters may serve as a surrogate, and compare gastric microcirculatory assessment to intra-operative determination of tissue viability.
June 2, 2014 - 7:51am
Purpose The purpose of this study is to better understand the role of genes in the development of immune-mediated diseases. Additionally, we hope to find similarities among different immune-mediated diseases that may point to common causes.
July 28, 2014 - 11:39am
Purpose This study aims to determine whether cystocentesis helps to increase the ease of passing a urinary catheter, and thereby trauma to the urethra.
October 6, 2014 - 3:04pm
Purpose The objective of this study is to assess the efficacy of tissue plasminogen activator (TPA) for thrombolysis in feline acute aortic thromboembolism (FATE)

Neurology

February 13, 2013 - 11:16am
Purpose and Brief Explanation of Study: In both dogs and people with Chiari malformation/syringomyelia (CM/SM), there is a high documented incidence of hyperesthesia (lowered pain threshold). The purpose of this study to validate the use of a sensory threshold test, von Frey anesthesiometry (VFA), for use in dogs withCM/SM. First we must determine what constitutes a normal response using VFA in Cavalier King Charles Spaniels (CKCS), then we will compare that response to what is seen in CKCS with CM/SM.
June 2, 2014 - 7:54am
Purpose The purpose of our research is to evaluate the usefulness of kinematic MRI in dogs with CSM. This project will further our current understanding of CSM, and will lead to a better understanding of the mechanisms associated with the disease and refinement of treatment strategies.

Surgery

August 9, 2013 - 9:35am
Purpose of Study The purpose of this study is to determine and compare the effects of warming small dogs prior to anesthesia (termed prewarming) with small dogs that are not warmed prior to surgery.
July 28, 2014 - 11:58am
Purpose The purpose of this study is to evaluate a rapid chemiluminescent test that measures parathyroid hormone, PTH. Our goal is to validate this rapid point of care assay to improve cure rates in canine patients undergoing parathyroidectomy for PHPTH and with postoperative monitoring determine patients that are at a higher risk of developing hypocalcemia, establishing guidelines for calcium supplementation in dogs.
August 11, 2014 - 12:18pm
Purpose The purpose of this clinical trial is to establish the effectiveness and safety of the Harmonic Aries Blade (Ethicon Inc.) in dogs with spontaneous disk disease requiring decompressive surgery.

Internal Medicine

January 29, 2014 - 11:17am
Purpose The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.
April 9, 2014 - 10:58am
Purpose The purpose of this study is to determine how amino acid status and markers of inflammation are affected in dogs with PLN. We will evaluate plasma amino acid concentrations and markers of inflammation [C-reactive protein (CRP); tumor-necrosis factor-α (TNF- α); interleukin-6 (IL-6)] in order to then develop novel medical and dietary therapeutic strategies for dogs with PLN.

Cardiology

June 2, 2014 - 7:44am
Purpose This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.
October 17, 2014 - 11:57am
Purpose The objective of this study is to assess right ventricular (RV) function in dogs at various stages of myxomatous mitral valve degeneration (MMVD).