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The goal of this study is to determine if a single intra-articular joint injection of autologous platelet concentrate processed using a filter-based platelet harvest device can improve lameness and joint pain, as determined by force plate kinetic analysis and visual analog scores of lameness and pain, in dogs with natural-occurring osteoarthritis compared with saline injected controls.
Osteoarthritis is a degenerative disease affecting joints. The bones within a moving joint are cushioned by cartilage, a fibrous tissue, and bounded by a sac of fluid called the synovial sac that keeps the joint lubricated and freely moving. Cells in the cartilage produce both the substances that comprised cartilage as well as the fluid of the synovium. These cells fail to function in osteoarthritis and that causes the space between the joints to narrow often to the point where bones rub against one another. The process causes progressively increasing pain and lameness.
Platelets from blood, while well known to be responsible for clotting, also contain a variety of growth factors that have been shown to promote wound healing. Some studies in humans have shown that platelet therapy may benefit patients with osteoarthritis but studies in the dog are lacking. Platelet therapy involves taking blood from your dog, sequestering the cells in a filter and then flushing them off the filter with a reverse flow of recovery solution that results in a smaller volume and higher concentration of cells than found in whole blood. This therapeutic option is attractive because the cells come from your own animals therefore adverse immune reactions are unlikely. Experience in humans and horses have shown this therapy to be safe, we are hoping to prove its effectiveness as treatment for osteoarthritis in dogs.
To qualify for enrollment in this study, dogs must:
Email: alicia [dot] bertone [at] cvm [dot] osu [dot] edu