Gastric and Buccal Microcirculation in Dogs

Purpose

To evaluate canine gastric serosa microcirculation in patients undergoing anesthesia for routine ovariohysterectomy and prophylactic gastropexy, and determine correlation between gastric serosal and buccal mucosal microcirculatory parameters

Background

The purpose of this study is to evaluate the microcirculation of the stomach and cheek in the apparently healthy dog. Many disease processes involve loss of the stomach’s blood flow that can make the disease worse and contribute to death. Evaluation of the blood flow in these diseases may improve the treatment. However, to fully understand these diseases and the changes on blood flow, the normal blood flow must be determined. This study will involve evaluation of the blood flow of the cheek and stomach in the normal dog. There has been no research that has evaluated the microcirculation of the stomach. Although previous research has evaluated the normal microcirculation of the cheek, this study also aims to determine if the cheek microcirculation can act as surrogate for the stomach microcirculation. It will also measure blood flow with blood levels of lactate, a product that increases in the blood when there is decreased blood flow.

While anesthetized for a routine ovariohysterectomy and prophylactic gastropexy, the microcirculation of the cheek and the stomach will be evaluated with a machine that does not damage any tissue. This machine will identify red blood cells within the smallest blood vessels of the organs.

Inclusion Criteria

Dogs must be undergoing routine ovariohysterectomy and prophylactic gastropexy

Study Design

Dogs undergoing routine ovariohysterectomy and prophylactic gastropexy will be treated based on standard of care, with the addition of microcirculatory imaging of the buccal mucosa and gastric serosa using sidestream dark field microscopy during surgery

Client Compensation

The study covers the cost of laboratory tests associated with the study and thirty minutes of general anesthesia.

Client Cost

The client will be responsible for all costs associated with the surgical procedure, postoperative care and any complications that could arise.

Contact

Please contact Dr. Edward Cooper – 614.292.3551 or Edward [dot] Cooper [at] cvm [dot] osu [dot] edu (Edward [dot] Cooper [at] cvm [dot] osu [dot] edu) for all questions related to this clinical trial.