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Evaluation of Variability of Echocardiographic Estimates of Pulmonary Arterial Hypertension in Dogs
This study addresses the hypothesis that echocardiographic variables commonly used in the non-invasive assessment of pulmonary hypertension in dogs are influenced by recording and measurement variability, sedation, stress, and exercise.
Pulmonary hypertension is a common clinical abnormality in dogs associated with clinical signs including but not limitied to coughing, exervise intolerance, weakness, fainting or passing out, and right-sided congestive heart failure contributing to poor outcome. Therefore, fast and reliable determination of pulmonary hypertension is of great clinical importance. Doppler echocardiography (DE), in particular tricuspid regurgitation (TR)-based DE pressure estimates, are the clinical gold standard method in the non-invasive estimation of pulmonary artery pressure (PAP) but are subject to a variety of independent factors influencing their accuracy. Recording and measurement error as well as effects of physiologic stressors have all been identified as independent factors leading to inaccurate pressure estimates. Although knowledge on principal components influencing DE hemodynamic estimates are well known and have been applied to a variety of echocardiographic variables used in the assessment of cardiac function over the past 40 years, variability of DE indices of PH has never been studied in people, dogs, or cats. This is surprising as such estimates provide relevant clinical and prognostic information. Moreover, effective treatments for PH became recently available, and DE has been used repeatedly in the evaluation of treatment efficacy. We hypothesized that DE methods used in the assessment of PH are affected by a variety of independent factors causing clinically relevant variability of pressure estimates.
- Healthy asymptomatic dogs with a TR murmur
- Dogs with mild to moderate pulmonary hypertension based on TR
- Dogs with severe pulmonary hypertension based on TR
A baseline echocardiographic study will be done to identify suitable dogs. Dogs then will complete the 6-minute exercise test (an easy leash walk for 6 minutes). An echocardiogram will be performed before and after 6 minutes of exercise, and after sedation. The sedation protocol is consistent with the standard of care for cardiology patients undergoing echocardiography.
Sedation and the echocardiography are to be covered by the study
Owners cover all regular costs (regular exam fee and charges for a comprehensive echocardiographic study).
Dr. K Schober (614-292-3551, ext. 4-8676)