Computed Tomography (CT) Imaging in Canine Osteosarcoma of the Appendicular Skeleton

Purpose

The goal of this study is to determine the accuracy of computed tomography (CT) scans in determining tumor size in dogs with osteosarcoma of the limbs.

Background

Appendicular osteosarcoma (OSA) is the most common type of bone cancer in dogs. This disease carries a poor prognosis with short survival times. Treatment includes chemotherapy and/or removal of the entire limb or palliative radiation therapy. Limb-sparing is an additional alternative to amputation involving surgical replacement of the diseased portion of the bone with healthy bone. Accurately determining the extent of diseased bone is of importance not only when performing a limb-spare procedure, but in serial monitoring of response of diseased bone to chemotherapy or radiation therapy when amputation is not performed.

Inclusion Criteria and Study Protocol

To qualify for enrollment in this study, dogs must:

  • Be diagnosed with presumptive sarcoma based on ultrasound-guided fine needle aspirate cytology prior to CT scanning
  • Not have received prior treatment for osteosarcoma
  • Not have a pathological fracture of the diseased bone

Study Design

Thin slice helical computed tomography (CT) will be performed on affected dog limbs prior to surgery. Measurements of tumor size obtained from CT images will be compared for accuracy with gross histopathology following amputation.

Client Compensation

The study will cover the cost of the CT, along with the histopathology. The owner is responsible for all other costs.

Contact

Dr. Eric Green, clinicaltrials [at] cvm [dot] osu [dot] edu, for further information.