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Research Summary

My primary research interest is focused on feline myocardial disease, assessment of LV diastolic function, all aspects of echocardiography, congestive heart failure, and evaluation of atrial function. I also study drugs that affect left ventricular diastolic function and left atrial and left atrial appendage function in cats short-term and long-term. Novel echocardiographic techniques such as strain and strain rate imaging are applied. In addition, pulmonary hypertension in dogs is another area of interest - its noninvasive diagnosis as well as its medical management.

Funded Research (Principal Investigator)

  • Title: Echocardiographic characterization of pulmonary venous flow in dogs.
    • Investigators: PI – Karsten Schober; Co-I’s – Virginia Luis Fuentes, Joanna Dukes McEwan, Anne French
    • Sponsor: German Academic Exchange Service
    • Type: Grant
    • Time: 1994-1995
    • Amount: Deutsch Mark 48,000 (approx. $25,000).
  • Title: Validation of noninvasive Doppler echocardiographic assessment of left ventricular diastolic function in cats.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, Virginia Luis Fuentes
    • Agency: Max Kade Foundation
    • Type: Grant
    • Time: 1999-2000
    • Amount: $38,500.
  • Title: Prediction of Congestive Heart Failure in Dogs by Radiography, Blood Biochemical Analysis, and Doppler Echocardiography.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, John Mattoon, Valeri Samii, Kathryn Meurs
    • Agency: Morris Animal Foundation
    • Type: Grant
    • Time: 2005-2008
    • Amount: $63,644.
  • Title: A study on the effects of atenolol versus diltiazem on LV diastolic function in asymptomatic cats with hypertrophic cardiomyopathy.
    • Investigators: PI – Karsten Schober, Co-I’s – John Bonagura, Virginia Luis Fuentes
    • Agency: The IAMS Company
    • Type: Grant
    • Time: 2004-2007
    • Amount: $11.907.
  • Title: Noninvasive Prediction of Congestive Heart Failure in Dogs by Doppler Echocardiography.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, John Mattoon
    • Agency: Canine Research Funds, Ohio State University Funds
    • Type: Grant
    • Time: 2004-2005
    • Amount: $13.905.
  • Title: Use of cardiac Troponin I for early Detection of Myocardial Damage in Dairy Cows.
    • Investigators: PI – Karsten Schober, Co-I’s – Anita Varga, Michael Rings, Paul Stromberg
    • Agency: USDA Funds, Ohio State University Funds
    • Type: Grant
    • Time: 2007-2008
    • Amount: $13,125.
  • Title: Echocardiographic assessment of the mitral valve apparatus in cats with hypertrophic cardiomyopathy.
    • Investigators: PI – Karsten Schober, Co-I – Amanda Todd
    • Agency: Ohio State Research Foundation
    • Type: Summer Research Grant
    • Time: June to August 2007
    • Amount: $4,200
  • Title: Effects of bradycardic agents on heart rate in control cats and cats with hypertrophic cardiomyopathy: A dose finding study
    • Investigators: PI – Karsten Schober; Co-I’s – Richard Cober, DVM; John Bonagura, DVM, MS; Tony Buffington, DVM, PhD; Sabine Riesen, DVM; Brian Scansen, DVM, MS
    • Agency: ACVIM Foundation and Ohio Animal Health Foundation
    • Type: Grant
    • Time: 2008-2009
    • Amount: $15,760.
  • Title: Selective If current inhibition in cats with hypertrophic cardiomyopathy
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, DVM, MS; Tony Byffington, DVM, PhD; Robert Hamlin, MS, PhD; Sabine Riesen, DVM, MS; Cynthia Carnes, PharmD, PhD
    • Consultant: Arun Sridhar, BS, MS, PhD
    • Agency: ACVIM Foundation
    • Type: Grant
    • Time: 2 years (2009-2010)
    • Amount: $70,189
  • Title: Study on the Effects of Pimobendan on Hypertrophic Cardiomyopathy in Cats.
    • Investigators: Multicenter trial, PI for OSU VMC – Karsten Schober
    • Sponsor: Boerhringer Ingelheim Vetmedica, Inc.
    • Type: Contract
    • Time: 2010-2012
    • Amount: $113,118
  • Title: Clinical evaluation of a fully electronic stethoscope in cats.
    • Investigators: PI – Karsten Schober, DVM, PhD; Co-I’s – Keith Blass, DVM; Brian Scansen, DVM, MS; Lance Visser, DVM, MS; John Bonagura, DVM, MS
    • Sponsor: 3M
    • Type: Non-restricted gift
    • Time: 2011-2012
    • Amount: $10,000
  • Title: Left atrial size in cats with congestive heart failure. A study of 100 cats.
    • Investigators: PI – Karsten Schober, Ellen Wetli (VMII student), Tod Drost
    • Sponsor: Summer research program CVM
    • Type: Grant
    • Time: 2012
    • Amount: $4,200