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Research Summary

My primary research interest is focused on:

  1. Feline myocardial disease (primary cardiomyopathies)
  2. Diastology
  3. All aspects of clinical echocardiography
  4. Congestive heart failure, and
  5. Pulmonary hypertension

I also study the effects of cardiovascular drugs on left ventricular diastolic function and left atrial appendage function in cats. Novel echocardiographic techniques such as strain and strain rate imaging as well as 4D imaging are applied.

Funded Research (Principal Investigator and Co-investigator)

  1. Title: Echocardiographic characterization of pulmonary venous flow in dogs.
    • Investigators: PI – Karsten Schober; Co-I’s – Virginia Luis Fuentes, Joanna Dukes McEwan, Anne French
    • Sponsor: German Academic Exchange Service
    • Type: Grant
    • Time: 1994-1995
    • Amount: Deutsch Mark 48,000 (approx. $25,000).
  2. Title: Validation of noninvasive Doppler echocardiographic assessment of left ventricular diastolic function in cats.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, Virginia Luis Fuentes
    • Agency: Max Kade Foundation
    • Type: Grant
    • Time: 1999-2000
    • Amount: $38,500.
  3. Title: Prediction of Congestive Heart Failure in Dogs by Radiography, Blood Biochemical Analysis, and Doppler Echocardiography.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, John Mattoon, Valeri Samii, Kathryn Meurs
    • Agency: Morris Animal Foundation
    • Type: Grant
    • Time: 2005-2008
    • Amount: $63,644.
  4. Title: A study on the effects of atenolol versus diltiazem on LV diastolic function in asymptomatic cats with hypertrophic cardiomyopathy.
    • Investigators: PI – Karsten Schober, Co-I’s – John Bonagura, Virginia Luis Fuentes
    • Agency: The IAMS Company
    • Type: Grant
    • Time: 2004-2007
    • Amount: $11,907.
  5. Title: Noninvasive Prediction of Congestive Heart Failure in Dogs by Doppler Echocardiography.
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, John Mattoon
    • Agency: Canine Research Funds, Ohio State University Funds
    • Type: Grant
    • Time: 2004-2005
    • Amount: $13,905.
  6. Title: Use of cardiac Troponin I for early Detection of Myocardial Damage in Dairy Cows.
    • Investigators: PI – Karsten Schober, Co-I’s – Anita Varga, Michael Rings, Paul Stromberg
    • Agency: USDA Funds, Ohio State University Funds
    • Type: Grant
    • Time: 2007-2008
    • Amount: $13,125.
  7. Title: Echocardiographic assessment of the mitral valve apparatus in cats with hypertrophic cardiomyopathy.
    • Investigators: PI – Karsten Schober, Co-I – Amanda Todd
    • Agency: Ohio State Research Foundation
    • Type: Summer Research Grant
    • Time: June to August 2007
    • Amount: $4,200
  8. Title: Effects of bradycardic agents on heart rate in control cats and cats with hypertrophic cardiomyopathy: A dose finding study
    • Investigators: PI – Karsten Schober; Co-I’s – Richard Cober, DVM; John Bonagura, DVM, MS; Tony Buffington, DVM, PhD; Sabine Riesen, DVM; Brian Scansen, DVM, MS
    • Agency: ACVIM Foundation and Ohio Animal Health Foundation
    • Type: Grant
    • Time: 2008-2009
    • Amount: $15,760.
  9. Title: Selective If current inhibition in cats with hypertrophic cardiomyopathy
    • Investigators: PI – Karsten Schober; Co-I’s – John Bonagura, DVM, MS; Tony Byffington, DVM, PhD; Robert Hamlin, MS, PhD; Sabine Riesen, DVM, MS; Cynthia Carnes, PharmD, PhD
    • Consultant: Arun Sridhar, BS, MS, PhD
    • Agency: ACVIM Foundation
    • Type: Grant
    • Time: 2 years (2009-2010)
    • Amount: $70,189
  10. Title: Study on the Effects of Pimobendan on Hypertrophic Cardiomyopathy in Cats.
    • Investigators: Multicenter trial, PI for OSU VMC – Karsten Schober
    • Sponsor: Boerhringer Ingelheim Vetmedica, Inc.
    • Type: Contract
    • Time: 2010-2012
    • Amount: $113,118
  11. Title: Clinical evaluation of a fully electronic stethoscope in cats.
    • Investigators: PI – Karsten Schober, DVM, PhD; Co-I’s – Keith Blass, DVM; Brian Scansen, DVM, MS; Lance Visser, DVM, MS; John Bonagura, DVM, MS
    • Sponsor: 3M
    • Type: Non-restricted gift
    • Time: 2011-2012
    • Amount: $10,000
  12. Title: Left atrial size in cats with congestive heart failure. A study of 100 cats.
    • Investigators: PI – Karsten Schober, Co-PI's - Ellen Wetli (VMII student), Tod Drost
    • Sponsor: NIH-sponsered summer research program at the CVM
    • Type: Grant
    • Time: 2012
    • Amount: $4,200
  13. Title: Multicenter study on the effects of Pimobendan in cats with hypertrophic cardiomyopathy.
    • Investigators: Karsten Schober (local PI)
    • Sponsor: Boehringer Ingelheim Vetmedica Inc.
    • Type: Industry contract
    • Time: 2011-2012
    • Amount: $115,000
  14. Title: Long-term effects of atenolol on survival in cats with hypertrophic cardiomyopathy.
    • Investigators: PI - Karsten Schober
    • Sponsor: IAMS and CVM
    • Type: Grant and start-up money
    • Time: 2003-2012
    • Amount: $15,000
  15. Title: Effect of Ivabradine and atenolol on dynamic obstruction of the left ventricular outflow tract in cats with hypertrophic cardiomyopathy.
    • Investigators: PI - Karsten Schober, Co-PI's - Keith Blass, Brian Scansen, John Bonagura.
    • Sponsor: ACVIM Cardiology Pacemaker Funds
    • Type: Grant
    • Time: 2012-2014
    • Amount: $9,000
  16. Title: Variability limits the utility of echocardiography as a diagnostic tool for estimating pulmonary artery pressure and pulmonary vascular resistance in dogs.
    • Investigators: PI - Karsten Schober, Co-PI's - Jaylyn Durham, Brian Scansen, John Bonagura.
    • Sponsor: ACVIM Cardiology PAcemaker Funds and Josie Joy Memorial Fund
    • Type: Grant
    • Time: 2014-2016
    • Amount: $18,397
  17. Title: Study on the feasibility of catheter-based estimation of pulmonary artery pressure in conscious, lightly sedated dogs.
    • Investigators: PI - Karsten Schober, Co-PI's - Jaylyn Durham, Brian Scansen, John Bonagura. 
    • Sponsor: Canine Research Funds, College of Veterinary Medicine, Columbus, OH
    • Type: Grant
    • Time: 2014-2015
    • Amount: $12,195
  18. Title: Placebo-controlled, double-blind, randomized clinical trial on the effect of Pimobendan on outcome in dogs with pre-clinical mitral valve disease.
    • Investigators: Local PI - John Bonagura, Co-PI's - Brian Scansen, Karsten Schober
    • Sponsor: Boehringer Ingelheim Vetmedica Inc.
    • Type: Industry contract
    • Time: 2011-2015
    • Amount: $25,000
  19. Title: Echocardiographic evaluation of the right heart in cats with hypertrophic cardiomyopathy.
    • Investigators: PI - Karsten Schober, Co-PI - Stephanie Savino
    • Sponsor: NIH-sponsered summer research program at the CVM
    • Type: Grant
    • Time: 2014-2015
    • Amount: $5,000
  20. Title: Retrospective study on canine pulmonary hypertension.
    • Investigators: PI - Karsten Schober, Co-PI - Maya Krasnow
    • Sponsor: Cardiology development funds
    • Type: Support
    • Time: 2014-2015
    • Amount: $4,000
  21. Title: Retrospective study on idiopathic LV hypertrophy in dogs - a multicenter trial.
    • Investigators: PI - Karsten Schober, Co-PI's - 17 cardiologists from the US, Canada, Europe, and Australia
    • Sponsor: None
    • Type: Support
    • Time: 2014-2016
    • Amount: 0
  22. Title: Pulmonary hypertension in cats with left-sided congestive heart failure.
    • Investigators: PI - Karsten Schober, Co-PI - Tommaso Vezzosi
    • Sponsor: None
    • Type: Support
    • Time: 2016
    • Amount: 0