Skip to main content


  • A complete PubMed list of Dr. Li Wu's publications are available HERE
  • Dr. Li Wu's publication list and citation data on ResearcherID are available HERE
  • Dr. Li Wu's publication citations in Google Scholar HERE

Original Research Articles


Kodigepalli KM, Li M, Liu S-L, and Wu L. Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells. Cell Cycle. 2017; 16(2):179-188. ePub on 12/9/16 Abstract

Kohnken R, Kodigepalli KM, Mishra A, Porcu P, and Wu L. MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells of Sèzary syndrome patients. Leukemia Research. 2017; 52:58-66. ePub on 11/17/16 Abstract

Li C, Wang HB, Kuang WD, Ren XX, Song ST, Zhu HZ, Li Q, Xu LR, Guo HJ, Wu L*, and Wang J-H*. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4+ T cells. J. Virol. 2017; 91 (1) e01830-16. ePub on 10/19/2016 * Co-corresponding authors. Abstract


St. Gelais C, Kim SH, Ding L, Yount J, Ivanov D, Spearman P, Wu L. A putative cyclin-binding motif in human SAMHD1 contributes to protein phosphorylation, localization and stability. J. Biol. Chem. 2016; 291(51): 26332–26342.  Abstract

Antonucci J, St. Gelais C, de Silva S, Yount JS, Tang C, Ji X, Shepard C, Xiong Y, Kim B, Wu L. SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. Nature Medicine, 2016; 22: 1072–1074. Abstract

Tirumuru N, Zhao B, Lu W, Lu Z, He C and Wu L. N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. eLife. 2016; 10.7554/eLife.15528. Abstract  News Report

Bonifati S, Daly MB, St. Gelais C Kim SH, Hollenbaugh JA, Shepard C, Kennedy EM, Kim DH, Schinazi RF, Kim B and Wu L. SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in myeloid cells. Virology, 2016, 495: 92–100. Abstract

Wang F, St. Gelais C, de Silva S, Zhang H, Geng Y, Shepard C, Kim B, Yount JS, Wu L. Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection. Virology. 2016; 487: 273-284. Abstract

Ren XX, Wang HB, Li C, Jiang JF, Xiong S, Jin X, Wu L, Wang JH. HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA. J Biol Chem. 2016. 291(9):4580-8. Abstract


St.Gelais C, Roger J, Wu L. Non-POU domain-containing octamer-binding protein negatively regulates HIV-1 infection in CD4+ T-cells. AIDS Res Hum Retroviruses. 2015; 31(8):806-16. Abstract

Tang C, Ji X, Wu L, Xiong Y. Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of T592. J Biol Chem. 2015; 290(44): 26352-9. Abstract

Mates JM, de Silva S, Lustberg M, Van Deusen K, Baiocchi R, Wu L*, Kwiek JJ*. A Novel histone deacetylase inhibitor, AR-42, reactivates HIV-1 from chronically infected cells. Retrovirology: Research and Treatment. 2015; 7: 1–5. *corresponding authors. Abstract   


St. Gelais C, de Silva S, Hach JC, White TE, Diaz-Griffero F, Yount JS, Wu L. Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. J Virol. 2014;88(10):5834-44. Abstract

de Silva S, Wang F, Hake TS, Porcu P, Wong HK, Wu L. Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients. J Invest Dermatol. 2014;134, 562-565. Abstract

Sharma A, Slaughter A, Nivedita J, Feng L, Kessl JK, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathogens. 2014. 10(5): e1004171. Abstract


de Silva S, Hoy H, Hake TS, Wong HK, Porcu P, Wu L. Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J. Biol. Chem.2013; 288(13):9284-92. Abstract

Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proc Natl Acad Sci U S A. 2013; 110(29):12036-41. Abstract

Dong C, Zhao G, Zhong M, Yue Y, Wu L, Xiong S. RNA sequencing and transcriptomal analysis of human monocyte to macrophage differentiation. Gene. 2013; 519 (2): 279-287. Abstract

Barrios CS, Castillo L, Giam CZ, Wu L, Beilke MA. Inhibition of HIV-1 replication by HTLV-1/2 Tax proteins in vitro. AIDS Res Hum Retroviruses. 2013; 29(7):1061-1067. Abstract

Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF, Wang JH. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. Virology. 2013; 442(2):163-172. Abstract


St Gelais C, de Silva S, Amie SM, Coleman C, Hoy H, Hollenbaugh J, Kim B, and Wu L. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology. 2012; 9, 105.Abstract

Coon S, Wang D, Wu L. Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV-1 in Europeans and African Americans. AIDS Res Hum Retroviruses. 2012, 28(12):1565-73. Abstract

Zhang C, de Silva S, Wang J, Wu L. Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One. 2012;7(5):e37477. Abstract

de Silva S, Planelles V, Wu L. Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. PLoS One. 2012;7(5):e35385. Abstract

St Gelais C, Coleman CM, Wang JH, Wu L. HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation. PLoS One. 2012; 7(3):e34521. Abstract

Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. A multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J. Biol. Chem. 2012; 287(20):16801-11. Abstract


Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, Sun J, Wu L, Zheng YT, Gao G. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A. 2011;108:15834.

Coleman CM, Spearman P, Wu L. Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef. Retrovirology. 2011; 8:26. Abstract

Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K, Wang J. Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011;6(11):e27609.Abstract


Raghavendra NK, Shkriabai N, Graham RLJ, Hess S, Kvaratskhelia M, Wu L. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells. Retrovirology. 2010; 7:66. Abstract

Blanchet FP, Moris A, Nikolic DS, Lehmann M, Cardinaud S, Stalder R, Garcia E, Dinkins C, Leuba F, Wu L, Schwartz O, Deretic V, Piguet V. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity. 2010 May 28;32(5):654-69. Abstract

Chung NP, Breun SK, Bashirova A, Baumann JG, Martin TD, Karamchandani JM, Rausch JW, Le Grice SF, Wu L, Carrington M, KewalRamani VN. HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN). J Biol Chem. 2010;15;285(3):2100-12. Abstract


Wang JH, Kwas C, Wu L. Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission. J Virol. 2009; 83(9):4195-204. Abstract

Dong C, Kwas C, Wu L. Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes. J Virol. 2009; 83(8):3518-27. Abstract

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, and Deretic V. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J. Cell Biol. 2009; 186: 255-268. Abstract


Wang JH, Wells C, Wu L. Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ T cells. Virology. 2008; 381(1):143-54. Abstract

Janas AM, Dong C, Wang JH, Wu L. Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry. Virology. 2008; 375(2):442-51. Abstract


Dong C, Janas AM, Wang JH, Olson WJ, and Wu L. Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection. J Virol. 2007; 81:(20) 11352-62 Abstract

Wang JH, Janas AM, Olson WJ, Wu L. Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells. J Virol. 2007; 81(17):8933-43. Abstract
About Journal Cover Illustration

Wang JH, Janas AM, Olson WJ, KewalRamani VN, Wu L. CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. J Virol. 2007; 81(5):2497-507. Abstract

Before 2007

Wu L, Martin TD, Han YC, Breun SK, KewalRamani VN. Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission. Retrovirology. 2004; 28;1(1):14 Abstract

Wu L, Martin TD, Carrington M, KewalRamani VN. Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission. Virology. 2004; 5;318(1):17-23. Abstract

McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 2003;300(5623):1295-7. Abstract

Bashirova AA, Wu L, Cheng J, Martin TD, Martin MP, Benveniste RE, Lifson JD, KewalRamani VN, Hughes A, Carrington M. Novel member of the CD209 (DC-SIGN) gene family in primates. J Virol. 2003;77(1):217-27 Abstract

Wu L, Martin TD, Vazeux R, Unutmaz D, KewalRamani VN. Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission. J Virol. 2002;76(12):5905-14. Abstract

Wu L, Bashirova AA, Martin TD, Villamide L, Mehlhop E, Chertov AO, Unutmaz D, Pope M, Carrington M, KewalRamani VN. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proc Natl Acad Sci U S A. 2002;99(3):1568-73 Abstract

Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, van Vliet SJ, Eilering JB, Martin MP, Wu L, Martin TD, Viebig N, Knolle PA, KewalRamani VN, van Kooyk Y, Carrington M. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 2001; 193: 671-678. Abstract

Reviews & Book Chapters (Invited and Peer-reviewed)

Kohnken R, Kodigepalli KM, Wu L. Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications. Molecular Cancer. 2015; 14(1):176. Abstract

de Silva S, St. Gelais C, Nagaraja T, and Wu L. Counteraction of SAMHD1 by Vpx. Encyclopedia of AIDS. Edited by Hope T, Richman DD, Stevenson M. Springer, 2015. Abstract

Wong HK, Wu L, and Porcu P, de Silva S, Mishra A. Cutaneous T Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome. Epigenetics and Dermatology, co-edited by Lu, Q., Chang CC, and Richardson BC. Academic Press. March 2015. ISBN: 978-0128009574. Abstract

Wu L. Samhd1 knockout mice: modeling retrovirus restriction in vivo. Retrovirology. 2013; 10:142. Abstract

Wu L. Cellular and biochemical mechanisms of the retroviral restriction factor SAMHD1. ISRN Biochemistry. 2013; Article ID 728392, 11 pages. doi:10.1155/2013/728392. Abstract

Wu L. SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells. Retrovirology. 2012, 9:88 Abstract

Coleman CM, Gelais CS, Wu L. Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells. Adv Exp Med Biol. 2013; 762:109-130. Abstract

Book series: Topics in HIV and AIDS. HIV Interactions with Dendritic Cells: Infection and Immunity. Edited by Wu L. and Schwartz O. Springer, New York. 2013. Weblink

Wu L. The role of monocyte-lineage cells in HIV persistence: mechanisms and progress. Journal of Microbes and Infections. 2011; 6 (3): 129-132. Abstract

St Gelais, C., and Wu L. SAMHD1: a new insight into HIV-1 restriction in myeloid cells. Retrovirology. 2011; 8:55 Abstract

de Silva S., and Wu L. TRIM5 acts as more than a retroviral restriction factor. Viruses. 2011; 3(7):1204-1209. Abstract

Coleman CM, Wu L. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology 2009, 6:51 Abstract

Janas AM, Wu L. HIV-1 interactions with cells: from viral binding to cell-cell transmission. Curr Protoc Cell Biol. 2009; Chapter 26:Unit 26.5 Abstract

Wu L. Biology of HIV mucosal transmission. Curr Opin HIV AIDS. 2008; 3(5):534-540 Abstract

Wu L, KewalRamani VN. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat Rev Immunol. 2006; 6(11):859-68 Abstract