The Use of flavophospholipol as a plasmid curing agent for Salmonella Typhimurim

This project intends to determine the effect of flavophospholipol, in vivo, on the prevalence and frequency of two predominant multi-drug resistant Salmonella strains of public health importance (S. Typhimurium DT104 and DT193) in pigs exposed to flavophospholipol and other feed grade antimicrobials. In addition, to compare and assess the counter-selective action of flavophospholipol on plasmid-borne (e.g. Typhimurium DT193) and chromosomally encoded (e.g. Typhimurium DT104) pentaresistant Salmonella strains. This will potentially identify flavophospholipol as a plasmid-curing agent and will have implications in the treatment of multi-drug resistant Salmonella with the use conventional antibiotics that are typically ineffective against these Salmonella phage-types of public health importance.

Personnel

Paul Dorr 
Derek Coombs
Wondwossen A. Gebreyes (Principle Investigator)