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A cancer-causing retrovirus exploits key proteins in its host cells to extend the life of those cells, thereby prolonging its own survival and ability to spread, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) and Ohio State's College of Veterinary Medicine.
The human T-lymphotropic virus type-1 (HTLV-1), which causes adult T-cell leukemia and lymphoma, produces a protein called p30 that is essential for the retrovirus to establish an infection. This study found that this viral protein targets two important cell proteins: ATM, a key player in a cell's response to DNA damage, and REG-gamma, which marks proteins within the cell for destruction.
"Our findings suggest that the p30 viral protein prolongs the survival of host cells through this interaction with ATM and REG-gamma, and the longer a virus-infected cell survives, the better chance the virus has to spread, " says principal investigator Michael Lairmore, DVM, PhD, professor of veterinary biosciences and associate director for shared resources at the OSUCCC – James.
The findings were published recently in the Journal of Biological Chemistry.
To read the full news release, click here.
About the College of Veterinary Medicine at Ohio State
Founded in 1885, The Ohio State University College of Veterinary Medicine is ranked fifth in the nation and includes more than 1,000 faculty, staff and students in the Departments of Veterinary Biosciences, Veterinary Clinical Sciences, and Veterinary Preventive Medicine. The Veterinary Medical Center is one of the largest specialty referral centers in the world, with more than 35,000 farm, equine, and companion animal patients each year. A nationally-recognized ambulatory practice and teaching unit in Marysville, Ohio provides farm animal experience to every veterinary student, and the Food Animal Health Research Program in Wooster, OH focuses on detection, control, and prevention of disease. Located on the only campus in the country with a comprehensive medical center offering seven health sciences colleges, we admit up to 162 veterinary students per class, and offer a new comprehensive graduate program in Veterinary and Comparative Medicine as well as a unique Master’s degree in Veterinary Public Health, in partnership with the College of Public Health. http://vet.osu.edu.