Goss Lab construction grant featured in "Frontiers"

Infrastructure improvements will being in 2011

From the Spring/Summer 2010 Issue of "Frontiers," a publication of The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.

Concrete results

Drs. Grever and Lairmore In addition to research grants, ARRA grants are improving the infrastructure of the OSUCCC-James. An $8 million construction grant will support finishing the fourth floor of Ohio State's Biomedical Research Tower (BMT) to provide a home base for the Experimental Therapeutics Program. Another construction grant for $3.9 million will fund the renovation of an 8,776-square-foot space within the Goss Laboratory building that houses a group of highly collaborative viral oncology researchers.

Michael Grever, MD, professor and chair of the Department of Internal Medicine and co-leader of the Experimental Therapeutics Program, says, "The OSUCCC-James is one of a limited number of institutions in the country that has National Cancer Institute funding for both phase I and II studies of new drugs."

Currently, investigators in the Experimental Therapeutics Program are spread out across various departments on campus.
Although the new floor of the BMT will not house all members of the program, it will bring together biologists, chemists, translational scientists and clinicians to develop new therapeutic strategies for cancer, says Grever. The construction project will create lab and office space for about 16 investigators and their groups-part of a plan to accelerate the recruitment of more faculty to the program. In addition, the 24,000-square-foot space will hold core laboratory facilities for medicinal chemists to synthesize new molecules, for pharmacokinetics studies to measure how drugs get distributed in the body, and for pharmacodynamics studies to measure how well drugs hit the targeted tumor cells.

When the Goss Laboratory building was built in 1961, the laboratory spaces were isolated from one another. The renovation will gut the space and install open laboratory benches and office space.

"This allows us to design a modern,interactive space for researchers doing similar things," says Michael Lairmore, DVM, PhD, associate dean of research for the College of Veterinary Medicine. The new space will house four investigators who have large laboratory groups and collaborate on an NIH Program Project Grant using retroviruses to understand the biology of cancer cells.

The space will also include tissue culture hoods for working with infectious viruses and a state-of-the-art facility for performing necropsies on infected animals. "These facilities, designed around a theme of our groups' research and equipment we share in common, will provide a real opportunity for us to accelerate our research," Lairmore notes.

Both the Goss Laboratory and Biomedical Research Tower renovations are expected to begin in spring and summer of 2011. The BRT renovation alone is expected to create 40 new construction jobs and space for 16 new faculty, and produce a demand for 100 support personnel.

For more features describing additional stimulus dollars improving the research facilities at Ohio State, see the full story in "Frontiers."

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Founded in 1885, The Ohio State University College of Veterinary Medicine is ranked fifth in the nation and includes more than 1,000 faculty, staff and students in the Departments of Veterinary Biosciences, Veterinary Clinical Sciences, and Veterinary Preventive Medicine. The Veterinary Medical Center is one of the largest specialty referral centers in the world, with more than 35,000 farm, equine, and companion animal patients each year. A nationally-recognized ambulatory practice and teaching unit in Marysville, Ohio provides farm animal experience to every veterinary student, and the Food Animal Health Research Program in Wooster, OH focuses on detection, control, and prevention of disease. Located on the only campus in the country with a comprehensive medical center offering seven health sciences colleges, we admit up to 162 veterinary students per class, and offer a new comprehensive graduate program in Veterinary and Comparative Medicine as well as a unique Master’s degree in Veterinary Public Health, in partnership with the College of Public Health. http://vet.osu.edu.