College of Veterinary Medicine

Professional Training and Experience

• 2011-present Executive Director, Life Sciences Network, The Ohio State University
• 2005-present Professor, Department of Veterinary Biosciences; Dept Molecular Virology, Immunology & Medical Genetics, Ohio State University, Columbus, OH
• 2001-2005 Associate Professor, Departments of Veterinary Biosciences and Molecular Virology, Immunology & Medical Genetics, Ohio State University, Columbus, OH
• 1999-2001 Assistant Professor, Department of Molecular Virology, Immunology & Medical Genetics, Ohio State University, Columbus, OH
• 1996-2001 Assistant Professor, Department of Veterinary Biosciences, Ohio State University, Columbus, OH
• 1992-1995 NIH Postdoctoral Fellow, McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI
• 1990-1991 National Institutes of Health Student Research Training Predoctoral Fellow, Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD
• 1987-1990 Hoffman LaRoche Predoctoral Fellow, Graduate Program in Molecular Genetics, The George Washington University Medical Center, Washington, D.C.
• 1985-1987 Research Biologist II, Antibiotic Genetics Group, Corporate Molecular Biology, Abbott Laboratories, Abbott Park, IL
• 1984-1985 Research Biologist I, Drug Discovery Group, Lederle Laboratories, American Cyanamid Company, Pearl River, NY

Research Interests

Discovery at the virus-host interface

Viruses are dependent on ubiquitous cellular processes and provide a tractable microcosm to elucidate principles and mechanisms underlying infectious disease and cancer. Our lab-team uses the retrovirus model system to define fundamental mechanisms of posttranscriptional gene expression in viruses and their host cells. We employ genetic tools and genomic, biochemical and biophysical approaches to dissect how cells fine-tune response to environmental or infectious pathogens and the requirements to sustain health or succumb to disease. We continue to be interested in manipulating the malleable retrovirus genome to produce gene transfer vectors to treat cancer and prevent pathogenic virus infection. Our discoveries at the virus-host interface demonstrate intriguing fundamental mechanisms and offer new strategies to diminish the severity of viral infections and counter progression to neoplasia. Please read more about our lab-team at the sidebar links.

Since joining the faculty of The Ohio State University in 1996, I have been active in graduate studies, both as a recognized mentor of graduate, veterinary, post-PhD students, junior faculty and as an active member of various committees, elected councils and as chair of the recently merged graduate program in the College of Veterinary Medicine. Presently I am the founding executive director of the Life Sciences Network of The Ohio State University. Please enter the gateway to research and graduate studies at lsn.osu.edu.